8OO6,1BGX,6VDD,7SXL,1TK8


Conserved Protein Domain Family
DNA_pol_A

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pfam00476: DNA_pol_A (This model is not part of the current CDD release)
DNA polymerase family A
Statistics
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PSSM-Id: 513484
Aligned: 557 rows
Threshold Bit Score: 238.892
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8OO6_A         226 KVLHNHSEELTLRLAELEK-KAHEI-AG-Ee--------FNLSSTKQLQTILF---EKQ-GIKPl-----K-KtpggapS 284  Escherichia ...
12_pfamImport    2 DYAEARLAELAAEYERWEQ-VANRYgV------------ENINSTAQLVDAFLgfgIRLtKkta-------------kgN 55  
Q05254         241 EYSRSLAEKWLADQEVWEAiAFTEYgV------------EKVNSTEDLAEGLEemgVKItGrte-------------tgK 295  Fromanvirus L5
P00581         299 kkpknkaqregREPCELDT-REYVAgAPyTpve---hvvFNPSSRDHIQ-------KKL-Q--EagwvptKytdk-gapV 363  Escherichia ...
XP_011063492  1780 KSLQELSSVVSNEMQSLET-KAYDL-AGrK---------FNFSSSKEVGQVLGlykDKKv-------------------S 1829
XP_001953657  1750 HRLGNLISQIAGSMKKLEA-KIFEL-NGsR---------FNINSSQAVAKVLGihrKPTgRv-----------------S 1801
O18475        1674 QRLQQLYQRMVAVMKKVET-KIYEQ-HGsR---------FNLGSSQAVAKVLGlhrKAKgRv-----------------T 1725 fruit fly
XP_002001461  1796 HSLQRLFQQMMATMKRLES-KIYEL-HGsR---------FNLGSTQAVAKVLGlhrKANgRv-----------------S 1847
XP_653960      272 KLLNEQRKKLIEEQHKIEM-ETKKI-IGrT---------INLSSPEQVKKELIrfn-----------igiDgIkkk---- 325 
1TK8_A         293 kkpknkaqreGREPCELDT-REY-V-AG-ApytpvehvvFNPSSRDHIQKKLQ---EA--GWVPt-----K-YtdkgapV 357  Escherichia ...
8OO6_A         285 --TSEEVLEEL---AlDYP---LPKV--ILEYRGLAKL--------KS--TYTDK---LPLMINPK-TG-RVHTSYH--- 336  Escherichia ...
12_pfamImport   56 laMDDDVLNGId-----HP---LAEA--VIKARRARKWsatwf---------------qraldGRDsRG-RVHASINsiq 109 
Q05254         296 rqVNAALLDKLvedGnE-----LAAI--AQEAKKLGKWrktwv---------------qkfidTRDsED-RCHTFINplq 352  Fromanvirus L5
P00581         364 --VDDEVLEGVr-vD-D-Pe-kQAAIdlIKEYLMIQKRigqsaegdKAwlRY-----------VAE-DG-KIHGSVN--- 421  Escherichia ...
XP_011063492  1830 --TSKTVLEKCd-----NP---ISTL--VISWRKLNAT--------KT--KMIYP---LLNLAq---GDsRVRGNC---- 1877
XP_001953657  1802 --TSREVLERLe-----AP---IANL--ICQYRKLNAL--------LV--KNVQP---LMKCCl---NN-RIHGH-S--- 1848
O18475        1726 --TSRQVLEKLn-----SP---ISHL--ILGYRKLSGL--------LA--KSIQP---LMECCq---AD-RIHGQ-S--- 1772 fruit fly
XP_002001461  1848 --TSRQILEKId-----SP---ISQL--ILNYRKLSML--------LA--KSMQP---LLKCCq---AN-RVHGQ-S--- 1894
XP_653960      326 atTDKKILSQSd-----HP---FAKL--VLEYRKISKL--------LS--GVIEQ---IRKCCIKSgDEyFIRTTWS--- 379 
1TK8_A         358 --VDDEVLEGVr--VdDPEkqaAIDL--IKEYLMIQKR--------IG--QSAEGdkaWLRYV-AE-DG-KIHGSVN--- 415  Escherichia ...
8OO6_A         337 ---QAVTATGRLSSTDPNLQNIP------V-RNEEGRRI----RQAFIAPE------DY-------V-IVSA--DYSQIE 386  Escherichia ...
12_pfamImport  110 artARMSITGSVPA-----QTFPagd-gyV-------------RHMFLAEEg-----HV---------SVSI--DFGNME 154 
Q05254         353 artSRMSITG-IPA-----QTLPssd-wiV-------------RRCFIAEPg-----DV---------MASV--DYQAQE 396  Fromanvirus L5
P00581         422 ---PNGAVTGRATHAFPNLAQIPg-----V-RSPYGEQC----RAAFGA--------EHhldgitgKpWVQAgiDASGLE 480  Escherichia ...
XP_011063492  1878 ---ITCTVTGRVSMHEPNLQNVPkd--fsFaDNNLVVSV----RMAFVPVl------GN-------I-MLSA--DYCQLE 1932
XP_001953657  1849 ---ITNTATGRISMAEPNLQNVAknfvvdVqDRGAIVSC----RSAFMPMDs-----TR-------C-LLSA--DFCQLE 1906
O18475        1773 ---ITYTATGRISMTEPNLQNVAkefsiqVgSDVVHISC----RSPFMPTDe-----SR-------C-LLSA--DFCQLE 1830 fruit fly
XP_002001461  1895 ---ITYTATGRISMSEPNLQNVAkdfhieLgKEQLKISC----RSAFAPMDe-----KR-------C-LISA--DFCQLE 1952
XP_653960      380 ---QTAIVTGRIQSKSPNLQQIP------K-QSFSLPQCliipRDLFITHNn-----NT---------FVAI--DYNQIE 433 
1TK8_A         416 ---PNGAVTGRATHAFPNLAQIPg-----V-RSPYGEQC----RAAFGAEHhldgitGK-------P-WVQAgiDASGLE 474  Escherichia ...
8OO6_A         387 LRIMAHLSRDKGLLTAFAEGK--------DIHRATAAEVFGLPLETVTSEQ--RRSAKAINFGLIYGMSAFGLARQLNIP 456  Escherichia ...
12_pfamImport  155 LRDLAAFSQDPTMLHAFANGL--------DLHQITADAAGVP-----------RKVGKGANFLTVFGGGWRAMVEQFGVD 215 
Q05254         397 LRVLAALSGDRNMIEAFENGA--------DLHQMTADAAQVP-----------RKVGKTANFQKVYGGGAKALAEAVGIS 457  Fromanvirus L5
P00581         481 LRCLAHF------MARFDNGEyaheilngDIHTK----------NQIAAELptRDNAKTFIYGFLYGAGDEKIGQIVGAG 544  Escherichia ...
XP_011063492  1933 LRLLTHFSQDSILCKIMKQSG--------DIFKNIAAKWNNVAEEQVTNEM--RQRTKQLCYGMIYGMGVKSLAENLCIS 2002
XP_001953657  1907 MRILAHLSQDKALVAAMNSPR--------DIFTSISAHWHRMNESEVSDQL--REGTKKICYGIIYGMSMRKLADELNVT 1976
O18475        1831 MRILAHMSQDKALLEVMKSSQ--------DLFIAIAAHWNKIEESEVTQDL--RNSTKQVCYGIVYGMGMRSLAESLNCS 1900 fruit fly
XP_002001461  1953 MRILAHLSQDKALLQVMNSTQ--------DLFTAIAAHWNKIDESNVSEQL--RNGTKQICYGIVYGMGMRSLSEALKCT 2022
XP_653960      434 LRILADFTKDHHLIEFFKSNT--------DVHRLIAAHWLKKNVNDITDDE--RRKAKTIVYGCIYGIGPFSLADQLHVS 503 
1TK8_A         475 LRCLAHF------MARFDNGEyaheilngDIHTK----------NQIAAELptRDNAKTFIYGFLYGAGDEKIGQIVGAG 538  Escherichia ...
8OO6_A         457 RKEAQKYMDLYFERYP---GV---LEYMERTRAQAKEQ-GYVETLDGRRLYLPDI-KSSNGARRAA--AERAAINAPMQG 526  Escherichia ...
12_pfamImport  216 EETAKRTLSAFADTYP---RV---GVLAKQLADEARRT-GFVYTPTGRRLPV---------DRGR----AYAALNYFIQS 275 
Q05254         458 IPVAKRVHEAFSATYP---GV---ERLSKKLAMEAGRN-GYIVNAMGRRLPV---------DSSR----TYSALNYMIQS 517  Fromanvirus L5
P00581         545 KERGKELKKKFLENTPaiaAL---RESIQQTLVESSQWvAGEQQVKWKRRWIKGLdGRKV-HVRSP----HAALNTLLQS 616  Escherichia ...
XP_011063492  2003 EPEAQEFLESFMSAYP---GI---YKWLNDILEEAHHD-GYVTTLLGRRREFPDL-SSTKSSVRAQ--AERQSVNTKVQG 2072
XP_001953657  1977 EQEAEVLSEQFHSNYP---GI---RSYTNRLIKYARHK-GYVETITGRRRYLENI-RSEDAGTRKK--AERQAVNSTIQG 2046
O18475        1901 EQEARMISDQFHQAYK---GI---RDYTTRVVNFARSK-GFVETITGRRRYLENI-NSDVEHLKNQ--AERQAVNSTIQG 1970 fruit fly
XP_002001461  2023 EQEAQMITEQFHLAYP---GI---KAYTMKVVKFARNN-GYVETITGRRRYLDHI-NSGEVQLKTQ--AERQAINSTIQG 2092
XP_653960      504 LDESKAFLESFLDQFP---AF---KKWKEETITNASTT-GFVHTINNRRRRINNL-TDCN-DKKTVaeSKRIAVNSPIQG 574 
1TK8_A         539 KERGKELKKKFLENTP---AIaalRESIQQTLVESSQWvAGEQQVKWKRRWIKGL-DGRKVHVRSP----HAALNTLLQS 610  Escherichia ...
8OO6_A         527 TAADIIKRAMIAVDAWL----QAEqpr----------------------vrMIMQVHDELVFEVHKDDVDAVA-KQIHQL 579  Escherichia ...
12_pfamImport  276 GSRDITARALLRLADAGfa------------------------------pyMRLPIHDEILFSFPRDAAAELT-REAARL 324 
Q05254         518 SSRDVTCRALIRLHEAGyt------------------------------pyLRLPIHDEIVASLPASEAERAA-AHIGHL 566  Fromanvirus L5
P00581         617 AGALICKLWIIKTEEML----VEKglkhgw----------------dgdfaYMAWVHDEIQVGCRTEEIAQVViETAQEA 676  Escherichia ...
XP_011063492  2073 SAADIVKKAMISIEDKI----RCYfpdsaiifpevhasrklrsnlqqrggyLVLQLHDELLYEVNLADLKKFA-AIIRES 2147
XP_001953657  2047 SAADIAKVAIIKSVKYMrrhcQKLfide-------------------nsvnLVLHIHDELMFEVPADKAKKIA-KLLKVV 2106
O18475        1971 SAADIAKNAILKMEKNIeryrEKLalgd-------------------nsvdLVMHLHDELIFEVPTGKAKKIA-KVLSLT 2030 fruit fly
XP_002001461  2093 SAADIAKSAILRMEKNLgryrEKLglak-------------------navnLVLHLHDELIFEVPTDKAKKVA-KVLSLT 2152
XP_653960      575 TAADIIKMCMIEIFKKL----HSSwvg----------------------vqLLLNIHDEIVLEVPDHLLDEVC-VTLKHL 627 
1TK8_A         611 AGALICKLWIIKTEEML----VEKglkhgw----------------dgdfaYMAWVHDEIQVGCRTEEIAQVViETAQEA 670  Escherichia ...
8OO6_A         580 MenC-Tr---LDVPLLVEVGSG-ENWDQ 602  Escherichia coli 'BL21-Gold(DE3)pLysS AG'
12_pfamImport  325 MefT-Ir----GVLIPAEGEIGdRSWGS 347 
Q05254         567 MqeQ-Mg----PVLVGTDPEVGkRSWGS 589  Fromanvirus L5
P00581         677 MrwVgDhw-nFRCLLDTEGKMG-PNWAI 702  Escherichia phage T7
XP_011063492  2148 MenV-Cq---LTVPLPVKIRVG-PAWGD 2170
XP_001953657  2107 MeaS-Ar---LTVPLKVKLKMG-SCWGN 2129
O18475        2031 MenC-Vk---LSVPLKVKLRIG-RSWGE 2053 fruit fly
XP_002001461  2153 MenC-Vk---LNVPLRVKLKIG-RSWGE 2175
XP_653960      628 MehI-Vk---LEVPLVVTVETG-KKWGS 650 
1TK8_A         671 MrwV-GdhwnFRCLLDTEGKMG-PNWAi 696  Escherichia phage T7
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