1RQ0,2IHR


Conserved Protein Domain Family
RF-1
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pfam00472: RF-1 
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RF-1 domain
This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.
Links
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Statistics
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PSSM-Id: 425702
Aligned: 802 rows
Threshold Bit Score: 39.7266
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1RQ0_A       187 EEKD--IEIRPEDLKI-ETFR-ASGHGGQYVNKTESAVRI---THlPT---------------------GI-VVSCQNER 237 Thermotoga mari...
BAM05053     226 DDGK--LEIDENELEVtAFAR-SSGPGGQNVNKVASAVRI---VHkPT---------------------Qi-MVVCSVHR 277 Phycisphaera mi...
XP_003176225  45 PRPT----IDDSEITG-TYLK-GSGPGGQKINKTSSAVQL---IHiPT---------------------Nt-VVKCQATR 93  Nannizzia gypse...
XP_007581511  42 PRPA----INEDDITE-SFLK-GSGPGGQKINKTSSAVQL---KHlPT---------------------Gi-VVKYQGTR 90  Neofusicoccum p...
XP_006685439  35 PKWL----IKEEDIEE-SFIKgGSGPGGQKINKTNSKVQL---KHiPT---------------------Gi-VVTSQHSR 84  Yamadazyma tenu...
EDK43701      28 PKWL----INEDELEE-KFLHgGSGPGGQKINKTNSKVQL---THkPT---------------------Gi-VVSCQESR 77  Lodderomyces el...
Q6BMW5        34 PKWL----IVEEEIDE-AFLKgGRGPGGQKINKSNSKVQL---THkPT---------------------Gl-VVTCQYSR 83  Debaryomyces ha...
Q07X45         2 IQITqrVILQDNEIEW-QFVR-SSGAGGQHINKVSTAAQLsfdIA-SSslpefyqqkllekadhritksGKvIIKCQQSR 78  Shewanella frig...
BAJ03750       2 IKITnrVLLQDNELEW-QFIR-SSGAGGQHLNKVSTAAQLifdIR-KSslpelyqqrllakadhritksGKvIIKCQASR 78  Shewanella viol...
Q2KZU8         2 LHIKdsLYLDERELDF-GMIR-AQGAGGQNVNKVSSAVHLrfdVP-ASslpdavkqavlalpdsrlskeGVlIIKAQAFR 78  Bordetella aviu...

1RQ0_A       238 SQYQNKQTALRILRARL----YQLQKEQKEREISQKR-KSqigt---gerSEK-----IRTYNF-PQNRVTDHR 297 Thermotoga maritima
BAM05053     278 KQEQNRKQALGILRAKLelieEEKRQAEMDDatg--------------gkVDRgwgtqIRSYVF-YDNRVKDHR 336 Phycisphaera mikurens...
XP_003176225  94 SQSQNRKIAKRILAEKI-------ELLEKGEQSRAAIvNNvkkkrkaskmKKS-----KRKYRAlEEEKRKK-R 154 Nannizzia gypsea CBS ...
XP_007581511  91 SRTQNRKTARRMLAERL-------EEIEKGPESRTQLkRAvqakkkassaKKS-----KRKYRAlEEA--KKAA 150 Neofusicoccum parvum ...
XP_006685439  85 SQEQNRQKAREILAEKL-------DLMENGPKSRVAVvTErkvklkqskqKKS-----HRKYRKiEEGRAKEKE 146 Yamadazyma tenuis ATC...
EDK43701      78 SQDQNRKKAREILALKL-------EDIQNPQGSRNTIlKEraqtvkanrmKKA-----NRKYRAlDEERSKQKA 139 Lodderomyces elongisp...
Q6BMW5        84 SQEQNRKRAREILALKL-------DELQNPEGCRTAIvNErktktkqgktKKA-----NKKYKVlDEERMKTKE 145 Debaryomyces hansenii
Q07X45        79 SQDFNRQTALEQFIELV----RSvg-----iVQKARIpTKat------kgSQK-----RRIETKkQRGATKAMR 132 Shewanella frigidimar...
BAJ03750      79 SQDSNRQTALAQFIELV----ASvg-----hTPKKRIaTKpt------rgSQR-----RRVDTKkQKGATKALR 132 Shewanella violacea D...
Q2KZU8        79 SQDKNRADAIERLLAVL----RQal-----fKDPPRRaTRpt------raSQR-----RRVQRKvQRGDVKRLR 132 Bordetella avium 197N
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