2FVO


Conserved Protein Domain Family
RF-1
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pfam00472: RF-1 (This model is not part of the current CDD release)
RF-1 domain
This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolyzis.
Links
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Statistics
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PSSM-Id: 513480
Aligned: 719 rows
Threshold Bit Score: 45.5421
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2FVO_A       187 EEKD--IEIRPEDLKIETFRASGHGGQYVNKTESAVRI---THl-PT----------------------Gi-VVSCQNER 237 Thermotoga mari...
WP_011704614   2 LVISnsVTLPWHELQFQTMRAQGNGGQHVNKTDSAVWLrfdYR--NSpsltplykegl-dklsdsrvhdGfiMIRVETHR 78  Aeromonas
WP_014293517   2 LEVSarVQIPEQELEFITMRAGGPGGQHVNKTDSAVQLrfdYA--GSpslpehykealakmrdhrvlasGliLIRVESER 79  Oceanimonas sp....
WP_012175145   2 LTISrnIAIDENELTFKFIRASGPGGQNVNKVASAVQLrfdVA--HSpslpgpvknrliklagrriseeGvlVIEAKRFR 79  Desulfosudis ol...
Q7UHV5         4 LPVTsrFVISEADLNWSASRSGGPGGQNVNKVNSKVTLrwkPQ--PQtgfdefwckrfvtqfgtrinkeGemVLHSEATR 81  Pirellula sp.
WP_015246457   2 LRINdrISIPLAEFQFDVSRSGGPGGQNVNKVNSKVLLrwsPA--TSpslpepvrarllaaltsrltreGelLVSSQRTR 79  Singulisphaera ...
WP_012501175   6 LLINpkLSIPVSEIEYRFARSSGKGGQNVNKVETKVELyfdIA--NSlslsdmmkrlllhklkgrisseGvlRLSCSASR 83  Chloroherpeton ...
WP_011699162   2 IRITnrISIPEEELSFTASLSSGPGGQNVNKLNTRVTLrfdLA--NSpslspedkaliatrlgtriakdGmlRVVSQSTR 79  Syntrophobacter...
WP_012765664   2 ISIThtLSIPENEITFLTSRSSGPGGQHVNKTSSKVTLvfnVQdsPSlsdyqktlim--srlsgrintkGelQLSCEEHR 79  Maridesulfovibr...
CCH48715      17 IRINdnLTLPDDEIRFINSRSSGPGGQHVNTTDTRVTLlfnIEksRSltplqkvaik--gklrrridkrGvfRVTSQKFR 94 

2FVO_A       238 SQYQNKQTALRILRARLYQlqkeqkerEISQKR-KSqigtgerSEKIRTYNF-PQNRVTDHR 297 Thermotoga maritima
WP_011704614  79 SQDMNRKEAMNRLVELLKKaa-----wRPKARHaTKpt---rsSQRKRVDAKkRKGEIKSTR 132 Aeromonas
WP_014293517  80 SQLMNKEAAKAALVALLQQag-----kPVKVRRpTKps---kaAKAKRADSKtHRGKIKSGR 133 Oceanimonas sp. GK1
WP_012175145  80 EQGKNRQDAIDRLVALVARal-----vVPRARKkTApt---kaSKRRTVDEKvYRGRVKQRR 133 Desulfosudis oleivorans
Q7UHV5        82 DQSRNLADARERLVSMLLGcr-----lPPKKRNaTRpt---lgSKRRRLEGKrQQSEKKRLR 135 Pirellula sp.
WP_015246457  80 DQSRNLADCLAKVRELILAaa-----tPPKIRRpSRpt---haSKIRRVEAKgRRSATKQLR 133 Singulisphaera acidiphila
WP_012501175  84 SQIKNREEATQRFRKLLQTal-----aPEKKRLkTKps---lvAKEKRLLLKkSRSQVKSAR 137 Chloroherpeton thalassium
WP_011699162  80 SQHANRELAVERFAELLKSal-----kRAPVRKeTRvs---kaAKERRLEEKkLRSSVKRQR 133 Syntrophobacter fumaroxidans
WP_012765664  80 SQFRNKEEVVSRFTKMLAEal-----kPVRKRRkTKvp---ysAKRKRLDNKkKRSEVKKGR 133 Maridesulfovibrio salexigens
CCH48715      95 SQKTNKDSAIERFVELMQWal-----tPVMPRKdTAvp---ksAKRRRLDRKrRTSERKQQR 148
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