6QJH


Conserved Protein Domain Family
Tubulin-binding
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pfam00418: Tubulin-binding 
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Tau and MAP protein, tubulin-binding repeat
This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.
Links
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Statistics
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PSSM-Id: 425670
Aligned: 84 rows
Threshold Bit Score: 37.375
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6QJH_A          4 VQIINKKLD-LS-NVQSKCGSKDNIKHVPGGG 33   human
ESN97169      134 VKIDTVRLD-FKdKAQSKVGSKDNIKHKPGGG 164  Helobdella robusta
20_pfamImport   1 VKIVSQKLT-W--QAQSKVGSMENAAHKPTGG 29  
38_pfamImport   1 VQVGSAPSPnLK-VVRSKVGSLQNTSHKPGGG 31  
13_pfamImport   1 VQVGAAPSPnLK-AAKSKVGSLANTLHKPGGG 31  
A53253        821 RLATNTSAPdLK-NVRSKVGSTENIKHQPGGG 851  human
3_pfamImport    1 IRATNAPLPdLK-NVRSKIGSTDNMKYQPGGG 31  
Q78DZ1        300 LRLINQPLPdLK-NVKSKIGSTDNIKYQPKGG 330  Norway rat
21_pfamImport   1 LQTAPVPMPdLK-NVRSKIGSTENLKHQPGGG 31  
CAG03020       50 LAAAAAPMPdLK-NIKSKIGSTDNIKHQPGGG 80   spotted green pufferfish
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