4QW6,3UNB,5FMG,5TRR,4QZX,6GOP,4R00,3UNF,3JSE,3H4P,6HE9,4QVP,5DKJ,3UNE,4Y9Y,1M4Y,2Z3A,6HED,3H4P,3IPM,5CZ6,5D0S,4Y8S


Conserved Protein Domain Family
Proteasome

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pfam00227: Proteasome 
Proteasome subunit
The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologs vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria. The second is call beta-proteobacteria proteasome homolog (BPH).
Statistics
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PSSM-Id: 425538
Aligned: 154 rows
Threshold Bit Score: 89.1621
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4QW6_G    40 IN-SLAVRGKDCTVVISQK-KVP--D-KLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPC 114 Saccharomyces cerev...
4Y9Y_J     1 MDiILGIRVQDSVILASSK-AVTrgI-SVLKDSD-DKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSP 77  Saccharomyces cerev...
Q09720     1 MEsLLAVQGQDFVLTASSS-SAVrgI-TVLKPDD-DKSQILNSHNLMLYCGEAGDTTNFAEYIAANISLYTLRHNLNLSP 77  Schizosaccharomyces...
EGZ75301   1 mevlLGITGKDFTIIAASK-AAMrgA-TILKASD-DKTRSLNKHTLMAFSGEAGDTVQFAEYTQANAQLYSMRNGTDLSP 77  Neurospora tetraspe...
P0CQ12     1 MEcSFGITGKDYVILASDM-GAGr-S-IVRMKSDENKLKTLGPHLAMAFSGEPGDTNNFAEYIERNMRLYNIRNHFPLLP 77  Cryptococcus neofor...
P91477     1 MHfLVGISTENYVILAAD--KATfaYgAILADSENDKEYRLGKKLTMMCIGEEGDVAQFGDWTKRNLQLYSVRNGYEVSP 78  Caenorhabditis elegans
Q9VJJ0     1 MEtLLGIKGPDFVMLAADT-THArsI-IVMKEDQ-NKIHKVSDSLLISTVGESGDTEQFTEFISKNIALYKMRNGYDLSP 77  fruit fly
Q9VQE5     3 MEtILGIKGPDFVMLASDTmQAK--S-LVFMKDDQSKIHRLSDFNMMATVGDGGDTIQFTDFISKNLHLYKISHGYHLSA 79  fruit fly
Q9LST6     1 MEcVIGVVGRDFAVVAADT-SAVqsI-LVHKTDE-DKVMVLDSHKLMGASGEPGDRVQFTEFIQKNLHLYQFRNNIPLST 77  Japanese rice
O23714     1 MEcVFGLVGNGFAIVAADT-SAVhsI-LLHKNNE-DKIMVLDSHKLVAASGEPGDRVQFTEYVQKNVSLYKFRNGIPLTT 77  thale cress
4QW6_G   115 DvLAKRMANLSQIYTQRA-YMRPLGVILTFVSVD-EELGpSIYKTDPAGYYVGYK-ATATGpK-QQEITTNLENHFkksk 190 Saccharomyces cerev...
4Y9Y_J    78 Q-AVSSFVRQELAKSIRS--RRPYQVNVLIGGYDkKKNKpELYQIDYLGTKVELp-YGAHGyS-GFYTFSLLDHHY---- 148 Saccharomyces cerev...
Q09720    78 E-ATASFTRKQLATSLRS-RKPYQVNILLAGYET-NLGKpELFWLDYLATCVRVp-YACQGyS-SFYCLSIFDRYY---- 148 Schizosaccharomyces...
EGZ75301  78 S-ALANFVRGELATSLRS--RKPYNVNLLLGGVDpITHKpSLYWLDYLASLAKVp-YAAHG-YaQYYCLSILDKHH---- 148 Neurospora tetraspe...
P0CQ12    78 P-AASAWVRRTLAEAIRS--RHPYAVNLLLGGFDtTTSKpHLYWIDYLGTKAIVp-YAAHG-MgVYVSLSTMDKWW---- 148 Cryptococcus neofor...
P91477    79 S-CAHHFVRRSIAEGLRS--QDHYTVDVLIGGYDdKEDKaFLGSVDYLANGLGQQpYLFRGfCgRF-CYAIMDREY---- 150 Caenorhabditis elegans
Q9VJJ0    78 R-ESAHFTRKNLAEYLRS--RTPYQVFMFVAGYD-PNAGpELTFIDYLANALPVn-YAGHGy-gAIFASSIYDRYW---- 147 fruit fly
Q9VQE5    80 K-SAAHFTRKTLADYIRT-NTRYQVAMLL-AGYD-AVEGpDLHYIDSYGAAQSIn-HAGHG-WgSMFCGSILQRYW---- 149 fruit fly
Q9LST6    78 A----ATANFTRGELATAlRKNPYYVNVLLAGYD-SDVGaSLYYIDYIATFHKIE-KGAFGy-gSYFCLSLMDKLY---- 146 Japanese rice
O23714    78 A-AAANFTRGELATALRK---NPYSVNILMAGYD-DESGaSLYYIDYIATLHKVD-KGAFGy-gSYFSLSTMDRHY---- 146 thale cress
4QW6_G   191 IDHINEESWEKVVEFAITHMIDalgTEFSKNDLEVGVA 228 Saccharomyces cerevisiae S288C
4Y9Y_J   149 RPDMTTEEGLDLLKLCVQELEKr--MPMDFKGVIVKIV 184 Saccharomyces cerevisiae S288C
Q09720   149 KPDLTIDEAVRIMKLCFDELKKr--MPIDFKGFICKVV 184 Schizosaccharomyces pombe 972h-
EGZ75301 149 HPDITLHQGIKLLNLCTDELKRr--LPIDFKGMTVKav 184 Neurospora tetrasperma FGSC 2509
P0CQ12   149 YEDMDKKEGVDLLRKCIDETEKr--LTIKFDFNCILID 184 Cryptococcus neoformans var. neoformans JEC21
P91477   151 KKDMTEAEGLALMNKCIGEAKRr--FVANIPGYKVVII 186 Caenorhabditis elegans
Q9VJJ0   148 HPNITQAEAYDVFKKCIAEIQKr--LVVNLKNFTVAVV 183 fruit fly
Q9VQE5   150 NSKLSQEDAYSLMKKCVLEIQRr--LIINQRNFEVYVV 185 fruit fly
Q9LST6   147 RPDMSVEEAVDLVDKCIKEIRLr--LVVAPQNFIIKIV 182 Japanese rice
O23714   147 RSDMSVEEAIELVDKCILEIRSr--LVVAPPNFVIKIV 182 thale cress
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