7TQR,6V6H,1W27,2O7B


Conserved Protein Domain Family
Lyase_aromatic

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pfam00221: Lyase_aromatic (This model is not part of the current CDD release)
Aromatic amino acid lyase
This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities.
Statistics
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PSSM-Id: 513260
Aligned: 369 rows
Threshold Bit Score: 225.423
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7TQR_A                  10 LRVEDVYAVAVeYdRVSISDDtlKAVEEKHEAFLKLINSGKT-VYGVNTGFG-SLLNV-----HIe-------------r 69  Therm...
WP_025293022            61 LTIDDLVAVARyGaKVKVGDElrAGAAAAYGLLLQAQAEGVP-VYLFNRRPGsRREEV-----SLeg------------a 122 Sphin...
PRJNA213647:NX02_15085  29 LTIEQVVAVARgRaRVAVAPAarKRMDETFALMMQGAAEGVP-IYLFNRAPGsGRETPtftgdPMg-------------p 94 
WP_020952459            59 LTVEQVIEIARdGaKVEQSPEalQRAADAYGLLLQGAAEGMP-IYWFNRGSGsNRETVifdgdPTs-------------p 124 Parac...
WP_012868947            10 ISIHQVLSVARg-eGVEIHPEalQRCTATWEALMDIANRGHPkVYGLNTGVG-INKDQ-----EVt-------------k 69  Therm...
WP_006301822            11 LTVADLVSVAReGrRVEIAPEalERVRAASAFLHRIAEAGTPkVYGLNTGVG-INKDQ-----AVt-------------a 71  Amino...
WP_025371071            37 LTLQEVREVALdHrPVTLSEAgmRNVRRGHEIVMDAALGGVP-VYGLNVGVG-WNKDH-----PVfhevngrkvlsddll 109 Adven...
Q120I2                  17 LTIDQVLQVSReDrKVAVSNEswARVARSHALLLSYARLGQP-VYGLNRGVG-LNKDQ-----TPfsgdvi----apevr 85  Polar...
Q8EC45                  30 LTVDKLWEISKsGeDVNISKEgwERIRASYKAPIDAAEDGRS-IYGLTVNYG-ALKDQ-----RVagasve----nepnr 98  Shewa...
WP_012084371             9 LDRAAVLRVAA-GeRVELSAGlrRRLAGSRAAVLTALEGSGP-VYGVSTGMG-AMAGV-----DLd-------------d 67  Kineo...
7TQR_A                  70 DQEIELQKNLIRSHSS--------GVGDYLENR-----YVRAIMAVRLNSLAAGYSAVSADLLNMMVEMLNRDVIPAVPK 136 Therm...
WP_025293022           123 PDSESYRVEMARRYAQrppsrlpfGFGPDIPEEd----VGRAMLAVDLNNMR--YLAASPAYVDGIAALLNAGVTPAVYW 196 Sphin...
PRJNA213647:NX02_15085  95 ENRPRLEARVLAQFQN--------GANAGVGPEvagedKIRANMLVRANGMT--FLPASPQLLQGLVDLLNAGVTPVART 164
WP_020952459           125 ENDAMLKKQQLARFQN--------GAKGGYPPEifeeeLVRAIMAIRANTIT--YEAASPDLVRMLPLMLNHHVTPIVMS 194 Parac...
WP_012868947            70 DSYCRYNMNMLQVHCV--------GLPPYGNLE-----EARAVMVIKLNHLLMGYTGITPRFITLLKDMINLGVHPAIPL 136 Therm...
WP_006301822            72 EHYIEYNQNMLRVHCV--------GVPPYATEA-----QTRAVMTAKLHSLLGGHVGMKPDLVLLYRDFLNEGIHPLIPL 138 Amino...
WP_025371071           110 TLSVRFNEMSLRAHAA--------GVGKPMSAD-----VVRAGMLIRLNTFLSGAAGVQPEVASMYVDYLNHDITPVIPS 176 Adven...
Q120I2                  86 ALSETFNRNMLLSHTV--------AYGPLVPAD-----VVRAAMLIRLNTALFGGTGMQPEVVRQYAEFLNQGITPVIRG 152 Polar...
Q8EC45                  99 SESIKFNERQMRIQAA--------GMEPFLPEA-----ESKMAMVIRLNQMAAGFTGMSVDAANAYMEYINNDVYPLIPS 165 Shewa...
WP_012084371            68 AARARHQANLVVGRAV--------GSAPWLSER-----EVRAVLAVRLRTYLHPEAGVSPQLCERLVELLNARVHPQVPR 134 Kineo...
7TQR_A                 137 YGSVGX--DLAPLAHIGLAMM-GEGKAFFEGRLMDSARALEKAGLK--PYQFKEKEGVALINGTSFMSGILSIAVMDAHD 211 Therm...
WP_025293022           197 RGAIGEa-DFVPTGQV---LQ-GHGFAYYRGRKMVAADALRAAGLK--PVQLSGGDG-ALVTTSALTAGFSALLVHDLRQ 268 Sphin...
PRJNA213647:NX02_15085 165 IGGTGEa-DGPIVGNVNGVLV-GRGEAWFGGCRMPAADALAAAGLK--PIAPAPGDG-TVSTTNADYTAQAALLVADARR 239
WP_020952459           195 RGTLGEg-DLPTMGNIAAAMV-GAGEAYFEGKRMPAAEALEKAGLK--PLVPTAADEAALISTNAYAYAQLVMVVSDGRE 270 Parac...
WP_012868947           137 RGSVGEa-DIACLSHLGLVMT-GQGLVIQDGRPVPSGPELERMGLE--AVQPGPKDGLGLVTSNALGEALGALILDRIGR 212 Therm...
WP_006301822           139 RGSVGEa-DITSLSHLGMALL-GEGEAVYRGRTVPVAEALGKAGLT--PGTLGSRDGLALVSSNALGAALGALVLEEFRA 214 Amino...
WP_025371071           177 LGTVGEa-DITLASHIGLAMI-GEWDVFYQGKRLPAAEVMKQLNIA--PLKPVGKDFLSILSTNSLTAGQATLAALDTQA 252 Adven...
Q120I2                 153 QGSVGAa-DITVLPQIALALM-GEGEVFYRGQRMASAEVLRTAGLG--AIKPFAKDSLSMLSANAYGAALAAVAASDAQA 228 Polar...
Q8EC45                 166 RGSEGAn-DLSMVTHVGLALM-GEWDVMYQGKRRSSAEVRKELGLK--KYQPFGMDGISILSNSNVAEAQSITAVKKVEH 241 Shewa...
WP_012084371           135 RGN-GAagEIIPLAHVGAVVLgGSGT-------------LDGRALPefP--FGPKEGVAFLEGVPVATALATLHVAAADL 198 Kineo...
7TQR_A                 212 ILENAIRSALLSFEALGGTSKAFTPWILGARPHLGQVAIGNRFREYL--------TGSDIVkRADSVkVQDAYTLRCIPQ 283 Therm...
WP_025293022           269 MLQWHDVLWAMNLNGMNGSIGPMTLPVQSTRPFPWPNFAAKRVLDML--------KGSYVF-NGEPRiIQDPESLRATVW 339 Sphin...
PRJNA213647:NX02_15085 240 LLDWADLIYAMELNGMNSSVTPLFMPVQRHRPYKWLNWQAARTLGMI--------RGSYLFgEDPARiIQDPESLRASAI 311
WP_020952459           271 VLDWADLSYAIALNGMNSSLTPISAPVQAMRPYDWLNWDAARVLDMV--------KGSYLFeADPARiIQDPISMRASTQ 342 Parac...
WP_012868947           213 IVDTADLVYAMTLEAFHGNPSPLDPRAMDLYPSPGAQRSAQTVRSLL--------AGSYIW--DDPKsLQDPLSLRCSAM 282 Therm...
WP_006301822           215 LVDTADLAYALTLEGFRGNVSPLDPATFRVRPYRGGIASMEHARQLL--------EGSYLW--EVQAeLQDPLSLRCSVH 284 Amino...
WP_025371071           253 FLDKQVRLFAFMLEGFNGNVAPFSETAVAARPYAAMAQEAGRIRAAL--------VGSDLWrRSADRaLQDPLSFRTMAY 324 Adven...
Q120I2                 229 LLNQADVVAALSLEGLDGNVAPFLAVTQAQRPFFGQSAAAHHIVSLL--------QGSSLWqRSEQRpLQDPLSFRSTAQ 300 Polar...
Q8EC45                 242 LLDLSSVIIASSLEALNGNVSPFLWHTVDTKGWPQGHEAAESILSHL--------KGSYLWsLDSKRnLQDPLSFRSSGQ 313 Shewa...
WP_012084371           199 LLAQAELVLAASGEVLRASRDPVRAGAAR-----GDDVLAAVLARLRerrpggevHG-----------LQAPVSVRVGAA 262 Kineo...
7TQR_A                 284 VYGSVADVIDYVENVLSVEINSATDNPLFNge------------------------------eV--VSGGNFHGEPVALA 331 Therm...
WP_025293022           340 RVGSLWESWSRLRDNVLIQLNSTDHNPTVRpgfspgdswelatpqmmkyhvkggrwsngqggyI--LSNSDWDPYPLVDN 417 Sphin...
PRJNA213647:NX02_15085 312 RQGSAWLAWARLAETVSIAINGSDHNPAVVaglkpddawelntpqalryritgataagrrtgyI--FSNANWDPYPLDND 389
WP_020952459           343 RQGSAWMAWANLRDSLQIAINSSDHNPAVVpgigpdsswelsssqfmkyhvkggplsggksgyI--FSNANWDPYPIANE 420 Parac...
WP_012868947           283 VHGTVRDLIRRCIKVLTAHINAPDDNPLAfpd-----------------------------gtV--VPSALFEPLPWVVH 331 Therm...
WP_006301822           285 VHGAVRDALDHAEALLSVQLNGCDENPVVlve----------------------------egrL--VPCGNFEPLNWVLP 334 Amino...
WP_025371071           325 TLGVVQENLLRLAEDLQVQINASDDNPLVLrqaviardaaqsdq-----lrayrvtseqgegaI--YPTANFNFLPVASK 397 Adven...
Q120I2                 301 IHGAARDALAALHAQLVVQINSSDDNPTVAldvrpatnatpqe-------rryfvtegavqgaI--LPSASFDPTVWAVS 371 Polar...
Q8EC45                 314 ILAAAKEELRQAKELLNTAINHTTDNPIVHtnarddlwysns---------dyvdglrvggknVfvNSGSNFDNTQLAVQ 384 Shewa...
WP_012084371           263 ACALVHRRVHALAAAADRALEGVTDSPAFld------------------------------grF--GGTAGFAGTDLGAD 310 Kineo...
7TQR_A                 332 ADFLAIALTDLGNMVERRIARLVDTNL-S-GLPPFL----T-PDSGLNSGYMIPQ---YTAAALCNRNKVLAYPSSADTI 401 Therm...
WP_025293022           418 VEQVSIPLTNLMVAVVERIHRFEDVFFtGtDAKAVLarngGsEGVGNGGGGGGIA------DALWQELKPLANPIAPDGV 491 Sphin...
PRJNA213647:NX02_15085 390 VEAFTIALANMDVAVNQRLDRFNNSFFtV--IRPTDviadLpRTPGLAAGGFAPQgnaKVSTDLWQEIQGLAVPVAPAGH 467
WP_020952459           421 TEAFTIALTNAGAAVAQRLERFNNPFFtViTPSDVIekgtAsENPPSRGGYLPTD--------LWQELAELGNPVTPNGQ 492 Parac...
WP_012868947           332 FEGLKVALGHLAQTVARRTLRLGSDRFtG--LPRFL----NnD-PCNCHAFGVIQ---KTLSYLLAEVRHLCNPCSMDVE 401 Therm...
WP_006301822           335 FETLGVAAGHLSQTSVRRTLRLGSPRFtG--LPRFL----NpREGI-CHAFGVIQ---KTFTTLDAEIHHLAHPLSWDTT 404 Amino...
WP_025371071           398 VEYLNLSLAKLAESMVQQLIRLENPELtG--LPRFL----AaKTNH-GHAFGAIQ---KPFVEESIRIKLLAQPASLYGA 467 Adven...
Q120I2                 372 LEGVGIAMSHVAQSSAQRVLRLGDPAFtR--LSRFL----Sp-GGG-VLAYTTIQ---KTVSSLSTEVRALSQPVSSDSL 440 Polar...
Q8EC45                 385 LESLSRALAQVIHISAWRTTQLDDGHRtK--LTTYL----IsKENVGGDGFANIA---QSMSGLYAEAMSLTNSAAIYGV 455 Shewa...
WP_012084371           311 SDALAAALVHLAETGAARTHRMLDPARtG--LPPQL----SpE-PGVQAGLVAVH---KRAVGVVHRLRRFALPAGLGAV 380 Kineo...
7TQR_A                 402 PTSANQEDHVSMGATGSLKLLEIIDNVRYIIAIEYLLGSQALEFtDkgm-----spSTRKIYEKIRE 463 Thermoplasma acido...
WP_025293022           492 TADRGVGDLDAVPMLKLMRLRQAMHVSQDIMGQDLLNAAFWMDVrAledprrtfgdTATAVLAAFRT 558 Sphingomonas sanxa...
PRJNA213647:NX02_15085 468 AIIATVEDLQAQTRLKIARADTAIDRSFDLLAQNLLTASFWLDVrKaqdpgrafgpGPTAAWAAFRA 534
WP_020952459           493 AIVATVEDLEAQTRMKGQRARQAVSLMSHLLAQDLLTATYWLDIrKlqdpsrefgaAPTAAHAALRK 559 Paracoccus aminoph...
WP_012868947           402 SLSEDQEDRGCNTPMVMDQLGQIAQRLEALLAIEAIHAAQGMDLrGary-----gvGSSAALERLRR 463 Thermanaerovibrio ...
WP_006301822           405 PLSEDQEDRGCNTPYVMLNLGRILDNLAYILGMEFLHAAQAVDLrRppr----lgrGTEAAHRRFRE 467 Aminomonas paucivo...
WP_025371071           468 TLAGNIEDTTSMSGLAVRNTEQILDALYHIAAFQLLEGAQALELrDgfa----psaSSKALLASYRQ 530 Advenella mimigard...
Q120I2                 441 VLAGNIEDVASNAPLAAQRVAQQIKLVRTLLGIETIHAAQAIDLrLqaeptrtlgaGTRAFHKAFRA 507 Polaromonas sp. JS666
Q8EC45                 456 PTSVGIEETFSNVNLIANRLDKIADIAYEIYSYEVLHTTQGMDIrTkeysq-kmgnGTSEFLHEYRK 521 Shewanella oneidensis
WP_012084371           381 ETSLGQEDVQSFALESAEGLAEVLAGLREVVAVELLAVHRARLLrG----------GLAGVSAELGA 437 Kineococcus radiot...
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