2VK4,4ZP1,2Q27,1POW


Conserved Protein Domain Family
TPP_enzyme_M

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pfam00205: TPP_enzyme_M 
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Thiamine pyrophosphate enzyme, central domain
The central domain of TPP enzymes contains a 2-fold Rossman fold.
Statistics
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PSSM-Id: 425523
Aligned: 220 rows
Threshold Bit Score: 42.9362
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VK4_C            201 IENVLQLIKEAKNPVILADACCSRHD--AKAETKKLIDLTQFPA-FVTPMG-KGSIDEKHPRFGGvYVGTLSSPAVKEAV 276 Kluyveromy...
Q9K659            188 VKQAARELTELKNGIVFIGQGVR--R--AVREAIEMAERLRWPI-VTTPQA-KGYIPSGHPLNKG-VFGFAGHTTASDLL 260 Bacillus h...
Q3JBM9            217 IEALCDQIASAKKVVFVVGEDCR--E--AIDAILDLAFLIQSDV-VTTPHG-KGLVSPYHPLFRG-VIGFAGHRSASEIL 289 Nitrosococ...
Q2SJ09            200 VHRLLKELAYVQKATLVIGEGCA--G--AMEPLLALAESRNWLI-VTTPMG-KGLVSEYHPLYRG-VFGLGGHESARDAL 272 Hahella ch...
jgi:Franean1_1424 191 LRGFAERLSASRRPALVFGPEVDRSG--GWHAAVALAEKLRASVyGAPLPD-RASFPENHRLYQG-PLGMS-LKAISDRL 265
Q9L123            189 RRWLVEQVASARRPALVLGGDIDSAG--RFDDAVRLAERLGGPVwAAPSQF-RLPFPNRHPLFRG-VLPAG-IAPVSAAF 263 Streptomyc...
Q97XR3            187 IEFVLDKVKSASSIAIVAGYEVSIFS--AHEELVRLAEKLNAPIyTEPYLS-IFPIDSSNILFKGpLSRYK-ASDVVKEL 262 Saccharolo...
Q9HK28            167 VNRIAQAINESENPAIIFGSEIDEFN--AFSEAVEFARKVGCPVySEPLGN-RSSYISDDPQYAG-ELFPA-AILINLQL 241 Thermoplas...
WP_012029687      192 lQALAQRILKAQRPVIITGDEIVKSD--ALRAAADFAAAIGAPV-HQQSAPyGAHFLSEHPCYIG-SLSRT-QKQVRDLL 266 Bradyrhizo...
CAI49043          201 IATAADYFVEADQPVLVLGDHVARAGrdAVEAAVELAEATGARV-HGEILAsEINFPTDHDQWVS-FIG--PDESIASML 276
2VK4_C            277 ES--ADLVLSVGAL---LSDfNT------GSfsYSYkTKN-----IVEF-HSDYTKIRSAT-------FPGVQmkFALQK 332 Kluyveromy...
Q9K659            261 NGeeGDGLFIIGSS---LGEtAT------NNynKKL-TDGr---yVIQL-DHDKTVFNRKYkid-fpiVGDVK--ITLTE 323 Bacillus h...
Q3JBM9            290 SDpeVDTVVVFGAN---LGEwAS------NGwdTEA-LLNd---rLIHV-ENTQENLTRTPmar-lhvRGTLT--TICER 352 Nitrosococ...
Q2SJ09            273 HPdnAERVIVIGSA---LDEvTT------GGwdPNA-IFSn---rLIHL-SGNPDHLSRSVmsr-lsiLGSPR--LLLEP 335 Hahella ch...
jgi:Franean1_1424 266 TG--HDLVTIIGAEvfrYYPyVP------GDilPAGtE-------LLHI-AADPAMTGAARvgd--slLGDPR--LAIEL 325
Q9L123            264 EG--HDLVLVLGAPvfrYHEhLP------GRylPEgt-------rLIQV-TEDASAAARAPmge--alVADPG--AVIDV 323 Streptomyc...
Q97XR3            263 EK--YDLVLVIGGW---LNYvVFpdvdirLN--------------IVEV-TSDFKEASKRKwd---tiVCNPK--DFLIK 317 Saccharolo...
Q9HK28            242 MQ--HDLLVFIGSD--------I------TLypYTTdTVLpek-rkIFVgLNNTRRMGETYianpktfLRKIT--PLVKK 302 Thermoplas...
WP_012029687      267 AP--HDLLIVLGAD---PLRmSV------HS--ET--EPLpeglpIVQI-GLVDWELGKNFgae-ialKADVR--ETLLQ 327 Bradyrhizo...
CAI49043          277 MD--TDTLGLVGCS-------TN------TTllRHEsPLIdadttTVQV-SSDPDEVGKNHpad-aavIGDPG--RIMRA 337
2VK4_C            333 L 333 Kluyveromyces lactis
Q9K659            324 L 324 Bacillus halodurans
Q3JBM9            353 V 353 Nitrosococcus oceani ATCC 19707
Q2SJ09            336 F 336 Hahella chejuensis KCTC 2396
jgi:Franean1_1424 326 L 326
Q9L123            324 L 324 Streptomyces coelicolor
Q97XR3            318 L 318 Saccharolobus solfataricus
Q9HK28            303 K 303 Thermoplasma acidophilum
WP_012029687      328 L 328 Bradyrhizobium sp. ORS 278
CAI49043          338 I 338
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