3F1R,1BLA,1NUN,2FDB,4CJM,1QQK


Conserved Protein Domain Family
FGF

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pfam00167: FGF 
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Fibroblast growth factor
Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.
Statistics
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PSSM-Id: 425498
Aligned: 53 rows
Threshold Bit Score: 119.575
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3F1R_A        65 RRRQLYCRT-GFHLQILPDGSVQGTRQDHSLFGILEFISVAV-G--LVSIRGVDSGLYLGMNDKGELYGSEKLT-S-ECI 138 human
XP_003224286  52 RTYQLYSRTsGKHVQILDNKKINAMAEDGDAHAKLIVETDTFgS--RVRIKGAETGFYICMNKKGKLIGKSNGK-GkDCV 128 green anole
P63076        53 REYQLYSRTsGKHVQVTG-RRISATAEDGNKFAKLIVETDTFgS--RVRIKGAESEKYICMNKRGKLIGKPSGK-SkDCV 128 Norway rat
Q6SJP8        53 RVYQLYSRTsGKHVQIRG-HRVSATADDGNSYARLYVETDTFgS--RVRIKGAESGRYLCMNRRGKLVGKPNGR-GrDCI 128 zebrafish
CAF90913      30 RVYQLYSRTsGQHVQIQG-RRVTATAADGSPHARLFVETDSFgS--RVRIRGAESGRYLCMNRKGKLVAKPNGE-SrECI 105 spotted green p...
O89101        53 RLYQLYSRTsGKHIQVLG-RRISARGEDGDKYAQLLVETDTFgS--QVRIKGKETEFYLCMNRKGKLVGKPDGT-SkECV 128 house mouse
XP_001635198  41 RETQLYSRSsRGHLRIFN-RQIDAEGKDGDPYAKLILESDTFgG--RVKIKGDKTKHYLCIKKDGRLTSRKIPK-SpKCV 116 starlet sea ane...
EDO36781      45 RHVRIYSRSsKWYLRVAGSKIDARSKTTDDPNAVMVQESLSInGtiRVRLRSLVENTYICVTKDGKLTLEDNGA-SqNCQ 123 starlet sea ane...
2FDB_M        30 RTYQLYSRTsGKHVQVLANKRINAMAEDGDPFAKLIVETDTF-Gs-RVRVRGAETGLYICMNKKGKLIAKSNGKgK-DCV 106 human
4CJM_A         4 RLYQLYSRTsGKHIQVLG-RRISARGEDGDKYAQLLVETDTF-Gs-QVRIKGKETEFYLCMNRKGKLVGKPDGT-SkECV 79  human
3F1R_A       139 FREQFEENWYNTYSSNIYKhgdtGRRYFVALNKDGTPRDGARSKRHQKFTHF---L 191 human
XP_003224286 129 FTEIVLENNYTALQNAKY------EGWYMAFTRKGRPRKGSKTRQHQREVHF---M 175 green anole
P63076       129 FTEIVLENNYTAFQNARH------EGWFMAFTRQGRPRQASRSRQNQREAHFikrL 178 Norway rat
Q6SJP8       129 FTEIVLENNYTALENARH------EGWFVAFTRKGRPIRASKTRQNQREVHFikrL 178 zebrafish
CAF90913     106 FSEIVLENNYTAFQNAKY------EGWYVAFSRKGRPIKASRTRENQREVHF---I 152 spotted green pufferfish
O89101       129 FIEKVLENNYTALMSAKY------SGWYVGFTKKGRPRKGPKTRENQQDVHFmkrY 178 house mouse
XP_001635198 117 FKEAYTDDFFTQFISAYN------PKWMITVSKKGHTRPGFKGRNGSRSVQF---I 163 starlet sea anemone
EDO36781     124 FLEGY-RKGFTQFRSMYR------NNWYLGFKKSGNIKLPKNTTKSQTASLF---L 169 starlet sea anemone
2FDB_M       107 FTEIVLENNYTALQNAKY------EGWYMAFTRKGRPRKGSKTRQHQREVHF---M 153 human
4CJM_A        80 FIEKVLENNYTALMSAKYS----G--WYVGFTKKGRPRKGPKTRENQQDVHF---M 126 human
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