Conserved Protein Domain Family
Pro_isomerase

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pfam00160: Pro_isomerase (This model is not part of the current CDD release)
Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.
Statistics
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PSSM-Id: 513202
Aligned: 56 rows
Threshold Bit Score: 97.3514
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7NG65       261 MVRFTT-D--RGPFVALVDGFNAPVTAGNFLDLVQRG--------------------------FYNGLKITRAErfNLV- 310 Gloeobacter vio...
Q23JQ1         2 sliIETs---LGDLEVDLFVQKAPEISKNFLKLCKLK--------------------------HYNNALFYEVQknYLT- 51  Tetrahymena the...
Q6BPQ5         4 LLETTE-----GNIVIDLFIDQQPLACYNFLKLCKLN--------------------------YYFFTPFYNLHkdLIV- 51  Debaryomyces ha...
XP_013932339   2 svllETn---AGNLVIDLFVDSAPNESRTFIALCLSK--------------------------FYHYSPFVNVRknVAV- 51 
Q4DNS3        82 FMDVAIgScsPKRIEYELFTRKCPVAVENFVKLC-TGenvlprvpstagmgdpsfgdqflpqvTYKNSTFHRVHrgYLI- 159 Trypanosoma cruzi
Q019H4        64 FFDLRAgGyyLGKVVFEIKEDACPITAKNFMQLC-Ey--------------------------GCYAGTMFKVYpgNWV- 115 Ostreococcus tauri
Q6CCS1         5 FLDVTYdGqrIGRIKFKLYSEDLPKTCENFRQFC-TGeyrid-----------------nvpqGYKESTFHRVVkgFMI- 65  Yarrowia lipoly...
XP_001311112  14 FFDVSIaGnlIGRVKIELRPDICPLACENFRRFC-TGeyrpk-----------------gvplGYKGTRFHRVVpgFIV- 74 
Q4UIU6        29 FMDISLgSqfLGRLKIELFADKVPKTCENFRKFC-TGehkqn-----------------mvpvGYKGTKFSKVIkdYMVq 90  Theileria annulata
XP_001699890  22 afsIQQsSklLGTVVLELFTDIAPATCANFIKYIKD---------------------------GYQGTPLHRIVpnGWV- 73 
Q7NG65       311 ----------QTGDps-----------------gkGTGG-FTDPAtgk--lrTIPMEVRparkeaeitasqviqrrvdyv 360 Gloeobacter vio...
Q23JQ1        52 ----------SIKSkkat--------------tvfVET--GGDQQ-------YIHDEIDp-------------------- 78  Tetrahymena the...
Q6BPQ5        52 ----------SSGDpdypentdgd--ainsfgdvnVNNTtVKQNky-----lPVPNSQHe-------------------- 94  Debaryomyces ha...
XP_013932339  52 ----------DSGNpcyp-------------dplaAPQP-DKNIN-------YTPSSH---------------------- 78 
Q4DNS3       160 ----------QGGDvvs----------------gqGT-----EQLsiygetfDAPDEVs--------------------- 187 Trypanosoma cruzi
Q019H4       116 ----------VGGDftkldevvynaedpdyfdfanLLPDaMPGGQsiygayfD--DENy--------------------- 162 Ostreococcus tauri
Q6CCS1        66 ----------QGGDfvrgngl--------gtvsifGSAS--------------FPDERTis------------------- 94  Yarrowia lipoly...
XP_001311112  75 ----------QGGDcdtqdgy--------gcisiyGR-E--------------FNDEPs--------------------- 100
Q4UIU6        91 vpmiicieclQGGDfvkgdgt--------gcisiyGS-C--------------FDDENf--------------------- 126 Theileria annulata
XP_001699890  74 ----------QGGDivd------------------gsgK-GDpg-------fVLPDETY--------------------- 96 
Q7NG65       361 qdrfeldpiklreemsnlhkryiaddwkpvpygktiesypaLyyG-PP-GVFSMARy--eKDPNSA-SSQFFI-SFSDpe 434 Gloeobacter vio...
Q23JQ1        79 ----------------------------------------tNkhN-KI-GLLSTSNi--gQ--DRN-TSEFFI-TLTS-- 108 Tetrahymena the...
Q6BPQ5        95 -----------------------------------------YvdN-SI-GLVSFVTkkdtNGKDLViGSQFTI-SLTE-- 128 Debaryomyces ha...
XP_013932339  79 -----------------------------------------LspE-KL-GQVLFTSk-----GDEF-SPEFSI-CLGP-- 106
Q4DNS3       188 -----------------------------------------SsvFdQR-GLVGTAVsa----pHLN-GSQFFIlTAKE-- 218 Trypanosoma cruzi
Q019H4       163 -----------------------------------------DlkHsGA-GVLTMHNng-gEVPGQN-GSQFMI-TFDK-- 195 Ostreococcus tauri
Q6CCS1        95 ---------------------------------------gkTfpH-IE-GALSMANs----gKDTN-GCQFFI-TTRK-- 125 Yarrowia lipoly...
XP_001311112 101 -----------------------------------------AykF-DEtGIVAMANs----gPNSN-GCQFFI-TMNP-- 130
Q4UIU6       127 -----------------------------------------TvkH-DKlGVVSMSNt----gPNTN-GCQFFF-ITKE-- 156 Theileria annulata
XP_001699890  97 -----------------------------------------SvkHdAP-GVLGMAt---gGQPHTA-NTQFYI-SLSP-- 127
Q7NG65       435 lnptgKN--LSDG-KY-ANFGYIT--QGIRTLRQLKV---G-------------DTIQKAEI 474 Gloeobacter violaceus
Q23JQ1       109 -----SHlqHFDE-KH-TIFGQVQ--VGIDILEKFNTdviVdndnk----pyinHRILhtiv 157 Tetrahymena thermophila SB210
Q6BPQ5       129 -----NTe-NLKSfSQ-VYFGKVV--EGFQVLEKINL---SvvenletrrllkdIRITHTHN 178 Debaryomyces hansenii
XP_013932339 107 -----VT--DISG----HVFGTIG--EGFTTLEYIND---Cvldeag--rplkdIRILHTfv 150
Q4DNS3       219 -----AP--HLNG-TC-ICFGRVV--KGFDAVEEIERv-pLtpsgf----psrrVTIVDCGR 264 Trypanosoma cruzi
Q019H4       196 -----KN--QLDD-RH-VAFGQII--EGYDVFCALQKlgdArqsge----tvqrVTVERCGL 242 Ostreococcus tauri
Q6CCS1       126 -----CP--ELDG--ShVVFGHVI--EGMDVVKFVEN---Vpvvee---kpkrdVVVSECGE 170 Yarrowia lipolytica
XP_001311112 131 -----AP--ELND-SY-VVIGKVF--EGMLVLRHIES---Vplkphs-eiptldCIISQCGE 177
Q4UIU6       157 -----CD--WLDG-KN-VAFGTLIddESRLVLQKMQN---Vsvgeny--apklnLLVTECGQ 204 Theileria annulata
XP_001699890 128 -----LP--FLDG-KR-VAFGRVLnkQSLENLLALQT---Lptfqne--rpvpdVVIASCHV 175
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