2B71,7JTK


Conserved Protein Domain Family
Pro_isomerase

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pfam00160: Pro_isomerase 
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Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.
Statistics
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PSSM-Id: 425493
Aligned: 64 rows
Threshold Bit Score: 96.1798
Created: 16-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2B71_A        40 YITIYT-N---LGDFEVELYWYHSPKTCLNFYTLCeMg----------FYDNTIFHR-VIpnFVIQGGD----------- 93  Plasmodium yoelii
Q2L6V8         6 FMDITAdGa-pLGKLVFELNTEKCPKTCENFVKLC-Tgpp------gfGYKNCVFYR-VIptFCACSGD----------- 65  Caenorhabditis ...
XP_001609098  64 YFDFAAdRr-yLGRVLVGLYGRHQPLTCENIVQLC-Kgyqlg--eqtiGYRNSRISQ-IYpgNGIVLGDl---------- 128 Babesia bovis T2Bo
Q019H4        64 FFDLRAgGy-yLGKVVFEIKEDACPITAKNFMQLC-Ey----------GCYAGTMFK-VYpgNWVVGGDftkldevvyna 130 Ostreococcus tauri
NP_001018433 126 yMDIENgGe-aVGRLLFELFSDVCPKTCRNFKALCtgeaglsksnlelSYKGSVFHR-VVpnGWIQGGD----------- 192 zebrafish
EDP07586      22 afsIQQsSk-lLGTVVLELFTDIAPATCANFIKYIkD-----------GYQGTPLHR-IVpnGWVQGGD----------- 77  Chlamydomonas r...
EDW33296     246 YFDVEVrDtriQGRLIIQLFTEACPQVVLEFMRACtQg----------NSAAITFSRtLTp-mWLEGRL----------- 303 Drosophila pers...
Q23JQ1         2 sliIETs----LGDLEVDLFVQKAPEISKNFLKLCkLk----------HYNNALFYE-VQknYLTSIKS----------- 55  Tetrahymena the...
Q6BPQ5         4 LLETTE------GNIVIDLFIDQQPLACYNFLKLCkLn----------YYFFTPFYN-LHkdLIVSSGD----------- 55  Debaryomyces ha...
ESW95909       2 svllETn----AGNLVIDLFVDSAPNESRTFIALClSk----------FYHYSPFVN-VRknVAVDSGN----------- 55  Ogataea parapol...
2B71_A        94 -----PTGTg--------------KGgk-siYGE--------YfeDEIn-KELKH-TgA--GILSMS-NNGp----NTN- 135 Plasmodium yoelii
Q2L6V8        66 -----FETQn--------------ARr---dGGKstfgtkyfD--DEN--FEILHdK-K--GILGMD-NYGw---eNTN- 111 Caenorhabditis ...
XP_001609098 129 -----FHGDd--------------PL-----KSCtiyg-rtmP--EES--FEAPFvQ-E--GDIAML-TSRd----QSGl 171 Babesia bovis T2Bo
Q019H4       131 edpdyFDFAn--------------LLpdampGGQsiyg-ayfD--DEN--YDLKHsG-A--GVLTMH-NNGge-vpGQN- 185 Ostreococcus tauri
NP_001018433 193 -----ISPEkk------------------gtGGEsiy---gpTfeDENf-VISHN-K-R--GILGMA-NQGa----HSN- 235 zebrafish
EDP07586      78 -----IVDGsgkg-------------------------dpgfVlpDETy--SVKHdA-P--GVLGMA--TGgq--pHTA- 117 Chlamydomonas r...
EDW33296     304 -----DMGPstvlk------qdlrNI--------------------EHdfDVLNH-G-VdaGILSFPsRYVrs--hLCS- 347 Drosophila pers...
Q23JQ1        56 -----KKATtv------------fVEtg--gDQQ--------YihDEIdpTNKHN-K-I--GLLSTS-NIGq----DRN- 98  Tetrahymena the...
Q6BPQ5        56 -----PDYPentdgdainsfgdvnVNnttvkQNky------lPvpNSQh-EYVDN-S-I--GLVSFV-TKKdtngkDLVi 118 Debaryomyces ha...
ESW95909      56 -----PCYPdp-----------laAPqp-dkNIN--------YtpSSH---LSPE-K-L--GQVLFT-SKg-----DEF- 96  Ogataea parapol...
2B71_A       136 SSQFFITLAPLP--HLDG-KH-TIFARVS--KNMTCIENIAS-------Vqttatn--kpifdLKILRT 189 Plasmodium yoelii
Q2L6V8       112 SSRFYVTFRETP--WMNR-FH-VAFGELV--EGFDVLDAIENlgilegnGpqqgr----tkanIVIANC 170 Caenorhabditis elegans
XP_001609098 172 TSRFLITLTGNP--LLGR-HP-VVVGTVV--KGMKLIRSLGKe------Iikdgk----pvrdIRIINC 224 Babesia bovis T2Bo
Q019H4       186 GSQFMITFDKKN--QLDD-RH-VAFGQII--EGYDVFCALQKlg----dArqsge----tvqrVTVERC 240 Ostreococcus tauri
NP_001018433 236 GSQFYITLQPAT--WMDQ-KY-VAFGQLA--EGTDVLKRLEA-------Vptyne---rpkqdCKIVAC 288 zebrafish
EDP07586     118 NTQFYISLSPLP--FLDG-KR-VAFGRVLnkQSLENLLALQT-------Lptfqne--rpvpdVVIASC 173 Chlamydomonas reinhardtii
EDW33296     348 AINFTISFQPLS--ILNG--KrIAFGKVR--KGLHLLERIQD-------Atghla---tsqgvVLITGC 400 Drosophila persimilis
Q23JQ1        99 TSEFFITLTSSHlqHFDE-KH-TIFGQVQ--VGIDILEKFNTdv----iVdndnk----pyinHRILht 155 Tetrahymena thermophila SB210
Q6BPQ5       119 GSQFTISLTENTe-NLKSfSQ-VYFGKVV--EGFQVLEKINL-------SvvenletrrllkdIRITHT 176 Debaryomyces hansenii
ESW95909      97 SPEFSICLGPVT--DISG----HVFGTIG--EGFTTLEYIND-------Cvldeag--rplkdIRILHT 148 Ogataea parapolymorpha DL-1
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