Conserved Protein Domain Family
Metallophos

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pfam00149: Metallophos (This model is not part of the current CDD release)
Calcineurin-like phosphoesterase
This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.
Statistics
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PSSM-Id: 513191
Aligned: 324 rows
Threshold Bit Score: 33.4508
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O64245   3 KRIVVISDTQ---------------------------IPFDDRKQLK--AVVgfIGDTQPDEVVh-iGDLMDYPspsRWT 52  Fromanvirus D29
P50733  47 LTIFFISDIH----------------------------KRLIDQDLL--EKA--RSH-APHLVIi-gGDLAEGG---VPS 89  Bacillus subtilis sub...
Q9V2Q8   1 MDILVIGDLH---------------------------GVSIKIDVLK-----------IPDIAIq-lGDLSNYG---EPD 38  Pyrococcus abyssi
P47488   4 IKVLFLGDVYg-------------------------kAGRKIISDHL--PII--KKKYQLNLIIa-nAENTTNGkglSWN 53  Mycoplasmoides genita...
P75429   5 IKFIFLGDVYg-------------------------kAGRNIIKNNL--AQL--KSKYQADLVIvnaENTTHGK---GLS 52  Mycoplasmoides pneumo...
O51458   6 IKTLIIGDII---------------------------GESGLKKVFFnlKNI--KNKYRIDLVIa-nGENSSNGf-gITP 54  Lyme disease spirochete
Q9RUV0   1 MRVLFIGDVF---------------------------GQPGRRVLQN--HLP--TIRPQFDFVIv-nMENSAGGf-gMHR 47  Deinococcus radiodura...
O67663   1 MRILAIGDIIg-------------------------rPGRKALRELL--PQL--KEEVAYDVVIa-nVENSAGGf-gITK 49  Aquifex aeolicus
Q9RX10  36 VTVVGLNDFHgnleptsfagvmvpdpkdptkqvklttGGIEVIGGYL--DQE--RAK-NANLTFvgaGDLIGAS---PVT 107 Deinococcus radiodurans
Q9ZMW9  23 IVFLETSDIHgrlfsydy-----------avgeqkpnNGLTRIATLI--KKQ--RAE-NKNVVLidsGDLLQGN---SAE 83  Helicobacter pylori J99
O64245  53 KGSSEEFAQRIKpdseqakTRf--lAPLRAVYDgpv-gvhEGnHDRRPFDYLHKF---APALVEY-------ADQFKFEN 119 Fromanvirus D29
P50733  90 ARIEENIKRLVHfg----vPI----VFVWGNND-------YEvRQHKLYSIFKAH---------------------GVIT 133 Bacillus subtilis sub...
Q9V2Q8  39 I-IENLISELVTqld--pvPL----LVIPGNHD--------IyGLNDIFAAFQRF---NKLVKRA-----------GAIP 89  Pyrococcus abyssi
P47488  54 HYQILK-QAGID-------------YITMGNHT----------WFQKQDLELVLN---QVDVIRP-------LNLMQDFN 99  Mycoplasmoides genita...
P75429  53 LKHYEFLKEAGVn------------YITMGNHT----------WFQKLDLAVVIN---KKDLVRP-------LNLDTSFA 100 Mycoplasmoides pneumo...
O51458  55 EIANNLFRSGVN-------------VITTGNHVy------SN-CKINDYLNKQTY---ILRPNNF-------SDLLDGHG 104 Lyme disease spirochete
Q9RUV0  48 DAARGALEAGAG-------------CLTLGNHAw------HHkDIYPMLSEDTYPivrPLNYADP-----------GTPG 97  Deinococcus radiodura...
O67663  50 KVYEELLEIGID-------------VMTSGNHIw------DKkEVYNFIGEAYNL---LRPANYP-----------EGVP 96  Aquifex aeolicus
Q9RX10 108 SSLLRD-EPSVIg-----lSKlgmqYSSLGNHEf------DQ-GYKELLRMQNGGcdsNAPDKACkfqnpypRATFSWLG 174 Deinococcus radiodurans
Q9ZMW9  84 LFNDEPIHPLVRa-----eNDlkfdIRVLGNHEfnfskdfLEkNIKGFNGDVVNA---NIIKIAD-------NKPFVKPY 148 Helicobacter pylori J99
O64245 120 LLDfd---------gfGVTVLPEF-YKVA---------------------------------------------PGWIST 144 Fromanvirus D29
P50733 134 LRNe------------SVPFSYNGhtiaiagvd--------------------------------dirmemdhyEEAIKE 169 Bacillus subtilis sub...
Q9V2Q8  90 LMEgpli-----leeiGIVGVPGWyDYSLapgylnmtkdeyeikafgfrrledadyiksslsdeelvrwnlnllEKFISE 164 Pyrococcus abyssi
P47488 100 YFQlg---------kgSYLFSLNGlKIRItnllgtsin----------------------------lpfaitnpFVELKK 142 Mycoplasmoides genita...
P75429 101 FHNlg---------qgSLVFEFNKakiritnllgt----------------------------svplpfkttnpFKVLKE 143 Mycoplasmoides pneumo...
O51458 105 YCFltir-----dekvAVVNVQGVlnmnfivkn---------------------------------pfdntkklVNMLSN 146 Lyme disease spirochete
Q9RUV0  98 VGW-------------RTFDVNGEkltvvnllgrvf---------------------------meavdnpfrtmDALLER 137 Deinococcus radiodura...
O67663  97 GRG-------------YGIFKKNGvefavinlmgkvf-------------------------mdcnlenpfktfDRIYDE 138 Aquifex aeolicus
Q9RX10 175 ANVevkatgkpalpayGIQEIGGA-RIAFigavtkttptivspd----------------gvadlkfldeaesiNKYVPE 237 Deinococcus radiodurans
Q9ZMW9 149 IIKki---------dgVRVAVVGFlVPHVptweastpehfa----------------------glefldaeealKKTLSE 197 Helicobacter pylori J99
O64245 145 ------------HGHRGGV-------------RVTQKSADTAY--NA-MQRFG--------TSVII-GHTHRQ 180 Fromanvirus D29
P50733 170 ldesq---lnilVCHNPEI-------------------HEQIN------EDDG--------IDVILsGHTHGG 206 Bacillus subtilis subsp. sub...
Q9V2Q8 165 iresvn-dvilaLHFAPFKdslkytgnpeidyFSAYMGSQRFG--EF-ALRHN--------IGLIVhGHTHRS 225 Pyrococcus abyssi
P47488 143 l----------vLTKDCDLh------------IVDFHAETTSEknAF-CMVFDg------yVTAILgTHTHVP 186 Mycoplasmoides genitalium G37
P75429 144 lilkrdcdlhivDFHAETT-----------------SEKNAFC-----MAFDGy-------VTTIFgTHTHVP 187 Mycoplasmoides pneumoniae M129
O51458 147 kakt-----ifvDFHAESNy------------EKESFGYFLNG---F--------------VTGVVgTHTHVM 185 Lyme disease spirochete
Q9RUV0 138 ddlg----tvfvDFHAEATsek--------eaMGWHLAGRVAA---------------------VIgTHTHVP 177 Deinococcus radiodurans R1 =...
O67663 139 lkdkv--kiivvDFHAEATs------------EKWAFGI---------YVDGR--------ASFVYgTHTHVP 180 Aquifex aeolicus
Q9RX10 238 lkakgv-daiivLIHEGGV-------------SKDGFDKPACG--TLtGPIVNivnkldpaVDAVIsGHTHQG 294 Deinococcus radiodurans
Q9ZMW9 198 lkgk----ydilIGAFHLG-------------REDEKGGDGIP--DLaKKFPQ--------FDIIFaGHEHAV 243 Helicobacter pylori J99
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