2BQ8,1XZW,6OFD,5FCB,5I8R,3IB7,6ASC,4B2O,6TVG,3GVE,1S3L,1V73,1SU1,3ICF,5OBL,3H60,1G5B,5WLY,5K8K,3AV0,6S85,3T1I,4FBK


Conserved Protein Domain Family
Metallophos

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pfam00149: Metallophos 
Click on image for an interactive view with Cn3D
Calcineurin-like phosphoesterase
This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.
Statistics
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PSSM-Id: 425486
Aligned: 324 rows
Threshold Bit Score: 35.4374
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2BQ8_X    5 LRFVAVGDWGgvpnap--------------fhtarEMANAKEIARTV----------QIL-----GA-----DFILs-lG 49   human
P54602  590 LRILSMNDLHgkidqqyeld------ldgngtvdgTFGRMDYAAAYL----------KEKka-ekKN-----SLIVh-aG 646  Bacillus subtilis s...
Q9RX10   36 VTVVGLNDFHgnleptsfagvmvpdpkdptkqvklTTGGIEVIGGYL----------DQEra--kNA-----NLTFvgaG 98   Deinococcus radiodu...
O34313  669 LTVMHTNDTH---------------------------AHLDDAARRMtk-------iNEVrs-etNH-----NILLd-aG 707  Bacillus subtilis s...
O83142   34 LTIIHINDHHshlepeplel------avagerlraAVGGYAALVHEI----------QRLra-esKN-----ALVLh-aG 90   Treponema pallidum ...
Q9X6T9   37 LSILHINDHHsylephetri------nlngqqtkvDIGGFSAVNAKL----------NKLrk-kyKN-----PLVLh-aG 93   Haemophilus influenzae
Q9ZMW9   23 IVFLETSDIHgrlfsyd-----------yavgeqkPNNGLTRIATLI----------KKQra--eNK-----NVVLidsG 74   Helicobacter pylori...
O32133    5 LRLYHTNDLH---------------------------SHFENWPKIV----------DYIeqkrkEHqsdgeETLVfdiG 47   Bacillus subtilis s...
O82748  411 FWFDFMADTGd------------------------GGNSSYSVAKLLaqpfinvpldNDSis-leRG-----NILLi-gG 459  thale cress
Q9T049  368 FWFDFMADTGd------------------------GGNSSYSVAKLLaqpslrvpvaNNFis-lpRG-----NVLLi-gG 416  thale cress
2BQ8_X   50 DnfYFTGv---------qDINDKRFQEtF----------EDVFSDrsl----rkVPW----YVLA----GNHD------- 91   human
P54602  647 D--MIGGs----------SPVSSLLQD------------EPTVEL---------MEDigfdVGTV----GNHE------- 682  Bacillus subtilis s...
Q9RX10   99 D--LIGAs----------PVTSSLLRD------------EPSVIG---------LSKlgmqYSSL----GNHE------- 134  Deinococcus radiodu...
O34313  708 D--VFSGd----------LYFTKWNGL-A----------DLKMM-----------NMmgydAMTF----GNHE------- 742  Bacillus subtilis s...
O83142   91 D--ALIGt----------LYSTLFRGR-A----------DAVLM-----------NHagfdFFTL----GNHE------- 125  Treponema pallidum ...
Q9X6T9   94 D--AITGt----------LYFTLFGGS-A----------DAAVM-----------NAgnfhYFTL----GNHE------- 128  Haemophilus influenzae
Q9ZMW9   75 D--LLQGn----------SAELFNDEP-I----------HPLVRA---------ENDlkfdIRVL----GNHEfnf---s 115  Helicobacter pylori...
O32133   48 D--HLDRfq--------fVTEATFGKAnV----------DLLNR-----------------LHIDgaaiGNNEgi----- 85   Bacillus subtilis s...
O82748  460 DlaYPNPsaftyekrlfcPFEYALQPPhWyktdsisvnkPELPDGvsdlkhydgPQC----FLIP----GNHDw------ 525  thale cress
Q9T049  417 DlaYPNPssftyekrlfcPFEYALQPPrWykndsiavdkPELPNGvsdlksyegPQC----FLIP----GNHGefqvsaa 488  thale cress
2BQ8_X   92 --HLG-NVSAQIAYSKISkrwnfpSPFY--------------RLHFKIPQTNV---------SVAIfmldtVTLCGNSD- 144  human
P54602  683 --FDE-GTDELLRILNGGdh---pKGTSgy-----------dGQNFPLVCANCkm-----ksTGEPflpayDIINVEGVp 740  Bacillus subtilis s...
Q9RX10  135 --FDQ-GYKELLRMQNGGcd---sNAPDkackf----qnpypRATFSWLGANVev-----kaTGKPalpayGIQEIGGAr 199  Deinococcus radiodu...
O34313  743 --FDK-GPTVLSDFLSGNsa---tVDPAnr-----------yHFEAPEFPIVSanvdvsnepKLKSfvkkpQTFTAGEKk 805  Bacillus subtilis s...
O83142  126 --FDN-GNEGLKEFLHYL------EVPVls---------------aNVVPNAAs--------TLHGlwkpsAIVERAGEr 173  Treponema pallidum ...
Q9X6T9  129 --FDA-GNEGLLKLLEPL------KIPVls---------------aNVIPDKSs--------ILYNkwkpyDIFTVDGEk 176  Haemophilus influenzae
Q9ZMW9  116 kdFLEkNIKGFNGDVVNA------NIIKia-----------dNKPFVKPYIIK---------KIDG-----VRVAVVGFl 164  Helicobacter pylori...
O32133   86 -tLPHeELAALYDHAEFPvi---vSNLFdk---------------nGNRPSWAvp---------------yHIKSLKNGm 131  Bacillus subtilis s...
O82748  526 --FDGlNTFMRYVCHKSW------LGGWfm-----------pQK--KSYFALQ---------LPKGwwvfgLDLALHGD- 574  thale cress
Q9T049  489 fiFQI-NWFDG---LNTF------MRYIchkswlggwlmpqkKSYFALQLPKGw--------WVFG-----LDLALHGDi 545  thale cress
2BQ8_X  145 ----------------DFLSQQPERPRDVKLar---tqLSWLKKq--lAAAREDYVLVAGHYPVW-----SIAEHGPTHC 198  human
P54602  741 vafigvv--tqsaagmVMPEGIKNIEFTDEAtavnkaaEELKKK-------GVKAIAVLAHMSAE-----QNGNAITGES 806  Bacillus subtilis s...
Q9RX10  200 iafig-----avtkttPTIVSPDGVADLKFLdea-esiNKYVPEl---KAKGVDAIIVLIHEGGV------SKDGFDKPA 264  Deinococcus radiodu...
O34313  806 eagihpyilldvdgekVAVFGLTTEDTATTSsp---gkSIVFNDa--fETAQNTVKAIQEEEKVNk---iIALTHIGHNR 877  Bacillus subtilis s...
O83142  174 ----------------IGVIGLDTVKKTVESssp--gkDINFIDe---IEAVRRATVEMQQQGVNk---iILLSHAGFEK 229  Treponema pallidum ...
Q9X6T9  177 ----------------IAIIGLDTVNKTVNSssp-gkdVKFYDEia-tAQIMANALKQQGINKII------LLSHAGSEK 232  Haemophilus influenzae
Q9ZMW9  165 vphvpt----weastpEHFAGLEFLDAEEAL-------KKTLSE------LKGKYDILIGAFHLG------REDEKGGDG 221  Helicobacter pylori...
O32133  132 siaflg----vtvpyyPVYDKLGWTVTDALEsi----kETILEV-----KGQADIIVLLSHLGIL-----------DDQA 187  Bacillus subtilis s...
O82748  575 -------------------IDVYQFNFF----------SKLVKE----KVGENDAVIIITHEPNW-----LLDWYWKDDT 616  thale cress
Q9T049  546 dv----------------------------------dqFKFFSElvkdKVGESDAVIIITHEPNWlldwyWSGDTGQNVR 591  thale cress
2BQ8_X  199 LVkq-lrPL-LATYG--------VTAYLCGHDHNL 223  human
P54602  807 AD-----LAnKTDSE--------IDVIFAAHNHQV 828  Bacillus subtilis subsp. subtilis str. 168
Q9RX10  265 CG-----TLtGPIVNivnkldpaVDAVISGHTHQG 294  Deinococcus radiodurans
O34313  878 DL-----ELaKKVKG--------IDLIIGGHTHTL 899  Bacillus subtilis subsp. subtilis str. 168
O83142  230 NC-----EIaQNISG--------IDVIVSGDTHYL 251  Treponema pallidum subsp. pallidum str. Nichols
Q9X6T9  233 NI-----EIaQKVND--------IDVIVTGDSHYL 254  Haemophilus influenzae
Q9ZMW9  222 IP-----DLaKKFPQ--------FDIIFAGHEHAV 243  Helicobacter pylori J99
O32133  188 VA--------EAVPE--------IDVILESHTHHL 206  Bacillus subtilis subsp. subtilis str. 168
O82748  617 GKnmrhlIFeFLKGR--------CKLRMAGDLHHY 643  thale cress
Q9T049  592 HLic--dVL-KYRCK--------LRMA--GDLHHY 613  thale cress
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