Conserved Protein Domain Family
Cyclin_N
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pfam00134: Cyclin_N (This model is not part of the current CDD release)
Cyclin, N-terminal domain
Cyclins regulate cyclin dependent kinases (CDKs). Human Cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.
Links
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Statistics
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PSSM-Id: 513178
Aligned: 92 rows
Threshold Bit Score: 67.5527
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q56YF8  28 IIPWFFSREEIerNSPSRRDGIdlKTETR--------LRDSYCTFLEILGERLKVPQVTIATAIFFCHRFFL-RQ-SHAK 97  thale cress
Q9ZR04  26 TLPHSLFLVEF--QHMPSSHYFhsLKSSAfl----lsNRNQAISSITQYSRKFD-DPSLTYLAVNYLDRFLS-SE-DMPQ 96  thale cress
Q9SMD4  51 EELTSLFSKET--EYEISYNVLe----kNqsf---isSRRESVEWILKTTAYYSFSAQTGFLAVNYFDRFLL--F-SFNQ 118 tomato
Q9S7H9  61 DELATLLSKEN--EFHLGFQSLi----sDgsl---mgARKEALDWMLRVIAYYGFTATTAVLAVNYFDRFVS-GW-CFQK 129 tomato
Q9SN11  59 DELSTLISKQE--------PCLydEILDDefl---vlCREKALDWIFKVKSHYGFNSLTALLAVNYFDRFIT-SR-KFQT 125 thale cress
P42751  50 DSIACFIEDER--HFVPGHDYLsrFQTRSld----asAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLY-AR-RLPE 121 thale cress
P42752  65 DRIKEMLVREI--EFCPGTDYVkrLLSGDld----lsVRNQALDWILKVCAHYHFGHLCICLSMNYLDRFLT-SY-ELPK 136 thale cress
Q12477  19 EMIQFLATSTAsiIKIRENNNPiqGCRP-----------PDLSIFIKNVVIQSNVQTPTLMATSVYLNKLKS----VIPK 83  Saccharomyces cerevis...
O80513  23 RVAESNDLTRRvaTQSQRVSVFhgLSRPT----------ITIQSYLERIFKYANCSPSCFVVAYVYLDRFTH-RQpSLPI 91  thale cress
Q9VKF0 205 DIFD------------EKLHPLthDQVPDnydthnpeHRQ-IYKFVRTLFNAAQLTAECAIITLVYLERLLTyAElDVGP 271 fruit fly

Q56YF8  98 N------DRQTIATVCMLLAGKVEET-PVTLEDVIIASyerihkkdlagaqrKEvyDQQKELVLIGEELVLSTLNFDLC 169 thale cress
Q9ZR04  97 Skp---wILKLISLSCVSLSAKMRKPd-MSVSDLPVE---------------GE--FFDAQMIERMENVILGALKWRMR 154 thale cress
Q9SMD4 119 SlnhkpwMNQLVAVTCLSLAAKVEETdVPLLLDLQVE---------------ESgfLFESKTIQRMEMLILSTLKWKMN 182 tomato
Q9S7H9 130 Dkp---wMSQLAAVACLSIAAKVEETqVPLLLDLQVA---------------DSrfVFEAKTIQRMELLVLSTLKWKMN 190 tomato
Q9SN11 126 Dkp---wMSQLTALACLSLAAKVEEIrVPFLLDFQVE---------------EAryVFEAKTIQRMELLVLSTLDWRMH 186 thale cress
P42751 122 Tsg---wPMQLLAVACLSLAAKMEEIlVPSLFDFQVA---------------GVkyLFEAKTIKRMELLVLSVLDWRLR 182 thale cress
P42752 137 Dkd---wAAQLLAVSCLSLASKMEETdVPHIVDLQVE---------------DPkfVFEAKTIKRMELLVVTTLNWRLQ 197 thale cress
Q12477  84 NvygintTRHRIFLGCLILAAKTLNDsSPWNKHWTTYT--------------EG--LLRIREVNTIERELLEYLNWDVR 146 Saccharomyces cerevisi...
O80513  92 Ns----fNVHRLLITSVMVAAKF-------LDDLYYNNayya-----------kvgGISTKEMNFLELDFLFGLGFELN 148 thale cress
Q9VKF0 272 C------NWKRMVLGAILLASKV-------WDDQAVWNvdyc----------qilkDITVEDMNELERQFLELLQFNIN 327 fruit fly
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