3S6D,6CG9,4OHQ,1MO0,6OOI,5UJW,1YYA,4Y90,4Y9A,5CSR,2H6R,1W0M,2JGQ,6BVE


Conserved Protein Domain Family
TIM
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pfam00121: TIM 
Triosephosphate isomerase
Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.
Links
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Statistics
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PSSM-Id: 459680
Aligned: 207 rows
Threshold Bit Score: 127.242
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3S6D_A  37 TLLIISLKMYFT-PSRTIDYIQGLLE-PRNdiIrqenrSRLLlaLIPDFLTIYPCSEAIkefEsnlaapqdadTPppLLL 114 Coccidioides immitis RS
Q97VM8   4 PIIIINFKAYENsFGDKAVNLGKKIEkISKeyS-----VEII--LSTPATMIYRMSQEV---D--------------LPI 59  Saccharolobus solfata...
Q4JCD8   4 PVILINYKAYENsYGKKSIEITKKIEkVSKeyG-----TEII--VSVPATMIHRISEES---E--------------LTV 59  Sulfolobus acidocalda...
Q96YZ9   4 PIILINYKAYENsYGEKGVEISKKIEkVSKdyG-----VPII--ISVPATMIYKLSQIL---E--------------IPV 59  Sulfurisphaera tokoda...
Q9HQS4   1 MFVLVNLKAYPCdPVAIAEAAADVAEtT-P--------ATIA--VAPQPADIGRVADTG------------------ATT 51  Halobacterium salinar...
Q5V4J7   1 MFVLVNLKAYPCdPVEVATAAADVSDdS-G--------VRVA--VAPQAAQISAVAETG------------------VET 51  Haloarcula marismortu...
A2SSN5   4 PLILVNFKSYREgAGNAAGQIASAAElVMQesG-----VTIG--IAPQFVELHPFCKHY---E--------------IPV 59  Methanocorpusculum la...
Q8TUT9   5 PPVIVNFKAYSEaVGENALRLARVAAeVSEetG-----VEVG--ICPPHVDLRDVVREV---G----------DE--VTV 62  Methanopyrus kandleri...
A8MCN3   4 PVLIINMKAYPElLGGGAVKLAQVAEkVANnlG-----ASII--VAPPHTYLRQVAESV---------------N--IPV 59  Caldivirga maquilinge...
1W0M_F   4 PILIINFKAYGEaAGKRAVELAKAAErAARelG-----VNIV--VAPNHLELGLVSQSV---D--------------IPV 59  Thermoproteus tenax

3S6D_A 115 GAQDCFWDSLGPYTGEISPVCLRDMNVSIVELGHAERRAIFgetdQQVARKAAAAADQGLIPLVCIGEVSTlgpivSEAI 194 Coccidioides immitis RS
Q97VM8  60 YAEHVDPVPLGAFTGAILPEMVKDAGAKGTLINHSERRLRA----DEIDDVLKRTKKLGLKSILCVDRYEL-----VYPF 130 Saccharolobus solfata...
Q4JCD8  60 FAQHVDSGEQGARTGAILPEMIKDAGARGSLLNHSERRIRL----DEMAESLERIRVLNLESVVCVDRYEL--------- 126 Sulfolobus acidocalda...
Q96YZ9  60 YAQHVDALRHGAHTGAILPEMIKDAGAKGSLLNHSERKIRL----DEIHEAVTRIRDLGLESVVC-ADSYE--------- 125 Sulfurisphaera tokoda...
Q9HQS4  52 YAQHVSPTEHGSHTGSVLAESVADNGAVGTLLNHSEHRRRL----ADIDGSVAAAERAGLDTVVCANNPAQ-----VAAA 122 Halobacterium salinar...
Q5V4J7  52 WAQHVSAVEHGSHTGSTLAEAAADAGAVGTLLNHSENRLKL----ADIDGALDAADRADLETIVCANNPAQ--------- 118 Haloarcula marismortu...
A2SSN5  60 YAQHIDAVE-GAFTGRIPAFTVRAAGCVGSLINHSERRLTI----AEIEACVEAAKFNHLESVVC-----------TNNV 123 Methanocorpusculum la...
Q8TUT9  63 LAQAVDAAEPGGRTGHVTPEMVVEAGADGTLLNHSERRMLL----EDLKDVCRACINEGLLTIVCASDALA-----ARAA 133 Methanopyrus kandleri...
A8MCN3  60 YAQSADPVDPGARTGHIPLEFIKDAGASGVIINHSEHRLLL----NDIAMLVNKAKALNLETVVCSPDPLS--------- 126 Caldivirga maquilinge...
1W0M_F  60 YAQGADVEAGGAHTAHVSLENIKEAGGSGVILNHSEAPLKL----NDLARLVAKAKSLGLDVVVCAPDPRT-----SLAA 130 Thermoproteus tenax

3S6D_A 195 GravgeceaQIRPVLEALPrdAPVIFAYEPVWAIGKPQPARVDHVGAVVSGIRSVIERIDRHRKGEVRILYGGSAGPGLW 274 Coccidioides immitis RS
Q97VM8 131 S-------------LLK-----PDAILIEPPELIGTGVSVSKAKPEVITRAVDEI------RKSEGIYLIAGAGITTGED 186 Saccharolobus solfata...
Q4JCD8 127 ---------VLPVALLR-----PNAVLIEPPELIGTGIPVSKAKPEAITKAVEEIKKTKD------VYLLAGAGITTGED 186 Sulfolobus acidocalda...
Q96YZ9 126 ----------LVHPLALLK---PNAILIEPPELIGSGRAVSKEKPEVITRAVNEI------KKVEGVYLIAGAGITTGED 186 Sulfurisphaera tokoda...
Q9HQS4 123 A---------------ALG---PDAVAVEPPALIGTGTPVSQADPDIVSDAVAAa-----EAVDPSVDVYCGAGITTGED 179 Halobacterium salinar...
Q5V4J7 119 ----------IGAAAAL----DPDGVAVEPPELIGTGTPVSKADPDIVTGAVDAa-----ARVNGDVDVLCGAGISTGED 179 Haloarcula marismortu...
A2SSN5 124 G---------VSAAAAAFS---PTYVAVEPPELIGSGISVAKADPDIIRNSVAAV-----KKISSDVKVLCGAGIQSGEC 186 Methanocorpusculum la...
Q8TUT9 134 G---------------ALS---PHAVAVEPPELIGTGTPVSKADPEVVERSVEVV-----KEVSEETAVLCGAGITDGSD 190 Methanopyrus kandleri...
A8MCN3 127 -----------SAAAAALA---PTAVAMEPPELIGTGKSVSRTKPDVVVETVNAV-----KRVNGDVKVITGAGIEDYND 187 Caldivirga maquilinge...
1W0M_F 131 A---------------ALG---PHAVAVEPPELIGTGRAVSRYKPEAIVETV-GLVSRHF----PEVSVITGAGIESGDD 187 Thermoproteus tenax

3S6D_A 275 GPGGLGKEVDGMFLGRFAHDIEG----VRKVVREV 305 Coccidioides immitis RS
Q97VM8 187 VYKALKLGAHGIGVASAVMKAKEpekvVEDFITSA 221 Saccharolobus solfataricus P2
Q4JCD8 187 VFKAIELGADGIGAASAVMKAKEpekvVEDFVKNA 221 Sulfolobus acidocaldarius DSM 639
Q96YZ9 187 VYKAIELGADGIGVASAVMKSSTpekiVEDFIINA 221 Sulfurisphaera tokodaii str. 7
Q9HQS4 180 VVSAGDLGASGVLLASGVAKADDpraaLADLVAPL 214 Halobacterium salinarum NRC-1
Q5V4J7 180 LVSASDLGASGVLLASGVAKADDpraaLEDLVEPL 214 Haloarcula marismortui ATCC 43049
A2SSN5 187 VKTAVDLGADGVLLASSVVKAKDpeavLRDLVSLL 221 Methanocorpusculum labreanum Z
Q8TUT9 191 VRAAVELGADGVLVASGVVLADDpkeaLLDLISGL 225 Methanopyrus kandleri AV19
A8MCN3 188 VAKAIELGTVGVLVASAIVKAKD----WEAKITEL 218 Caldivirga maquilingensis IC-167
1W0M_F 188 VAAALRLGTRGVLLASAAVKAKDp---YAKIVELA 219 Thermoproteus tenax
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