8TZO,7DRT


Conserved Protein Domain Family
wnt

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pfam00110: wnt (This model is not part of the current CDD release)
wnt family
Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.
Statistics
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PSSM-Id: 513156
Aligned: 149 rows
Threshold Bit Score: 274.048
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8TZO_A         40 KIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERT---VFGKELKVGSREAAFTYAIIAAGVA 116 human
XP_015835988   60 RRYGLAKLQAKLCRSTMEAMPHVQKAAVLAADTCQTVFKDRRWNCSSITTAp---YLTPDLTRATREQAYVYAISSAALT 136
XP_002434188   47 QLHGLHARQVRLCRARLGAMPHVVEASQLAVDACQETFRDRRWNCSSVLRAp---DLMADLTAGTREQAFVYALSSASLT 123
XP_031410500   44 LLAGLVPDQVQICRRNLEVMHSIVQAASETKSICQKTFSGMRWNCSSIQRAp---SFGPDLLKGTRESAFVHALSAAAIA 120
XP_012400784   47 QLEGLVSSQVQLCRSNLELMQTIVQAAREAMKTCRKAFSDMRWNCSSIERAp---NYLLDLERGTRESAFVYALSAAAIS 123
XP_005806753   47 LLPGMVSSQAQLCRSNLELMQTIIQAAREVKKTCQKTFGDMRWNCSSIEIPVnatKYRPDLERGTREAAFVYALSAATIS 126
Q28J82         45 LLDGLVPEQSQLCKRNLELMQSVVNAAKQAKLTCQMTFSDMRWNCSSVENAp---NFTPDLSKGTRESAFVYALASATIS 121 tropical clawe...
51_pfamImport   1 LLDGLVPDQLQLCRRNLELMQSIVHAAKLTKLTCQKTFTDMRWNCTSIESAp---HFTPDLAKGTRESAFVFSLAAAVVS 77 
O73864         46 LLDGLVPDQQQLCKRNLELMHSIVRAARLTKSACTSSFSDMRWNWSSIESAp---HFTPDLAKGTREAAFVVSLAAAVVS 122 zebrafish
XP_046450779   63 RQKLLTKEQVKVCLQQPATMLSVWEAGQSSSQACRQAFAERRWNCSSIDFLp---RKAPDLSHGTREQAWVYALTSAALT 139 common water flea
8TZO_A        117 HAITAACTQGNLSDCGCDKE---KQGQyHRdEGWKWGGCSADIR-YGIGFAKVFVDAREI-------------------- 172 human
XP_015835988  137 YTMARACASGTLYHCTCAGK---PDEP-PN-SNFQWGGCGDNIH-WGVYFAKRFIDNVEKnnvdksrkrrkg-------- 202
XP_002434188  124 QTWARACGQGRLTGCGCGRA---PREP-PQ-GDFKWGGCADNVR-FGARLARAFTDAPWKra------------------ 179
XP_031410500  121 HSIAQACASGSLPLCSCGSVpsel-----pgpdFRWGGCGDNLH-YGLQLGAAFADSPLKss------------------ 176
XP_012400784  124 HTIARACTTGDLPGCSCGPVpgeTP----G-PGYRWGGCADNLN-YGLLMGAKFSDAPMKvk------------------ 179
XP_005806753  127 HAIAQACTSGDLRTCSCGPI---PAEI-PE-PGYRWGGCADNLN-YGIFMGSKFSDAPMKmk------------------ 182
Q28J82        122 HTIARACASGELPTCSCGAT---PAEV-PG-TGFRWGGCGDNLH-YGLNMGSAFVDAPMKss------------------ 177 tropical clawe...
51_pfamImport  78 HSIARACASGDLPSCSCGPA---PAEQ-AG-PDFRWGGCGDNLR-YGLQMGSAFSDAPMKss------------------ 133
O73864        123 HAIARACASGDLPSCSCAAM---PSEQ-AA-PDFRWGGCGDNLRyYGLQMGSAFSDAPMRnr------------------ 179 zebrafish
XP_046450779  140 RAVARGCSSGILKQCACGSF---PRHP-PD-GQFKWGGCGDDIK-YAKQFAKSFTDASLKrvnrkaatnllrvsdhsesl 213 common water flea
8TZO_A        173 ------------K-QnARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVH-V 238 human
XP_015835988  203 -yeydedrksklVrEeIAA-VNLHNNRVGRRIIRESIQTQCKCHGVSGSCNVKTCWKGLPPMFEIGRKLMKQYTNAKE-V 279
XP_002434188  180 -----------pPdTaFRALLNRHNYKAGRQAVHESLTTLCKCHGVSGACNIKTCWRGLSSLRHVSQRLRRRYQVAVE-V 247
XP_031410500  177 ----------mlGlQaLRA-MNWHNNVAGRQVLSESLDTKCKCHGVSGSCSVKTCWKALPSLGEIASELKSKYLAAIR-V 244
XP_012400784  180 -----------kTgSqANKLMHLHNSEVGRQALRASLEMKCKCHGVSGSCSIKTCWKGLQELRDVAQDLKTKYLSATK-V 247
XP_005806753  183 -----------rSsSsANKLMQLHNSEVGRQALKEALVMKCKCHGVSGSCSIRTCWKGLQDLRDIAMDLKSKYLSATKvV 251
Q28J82        178 ----------ksGgTqATKMINLHNNAVGRQVLMDSLETKCKCHGVSGSCSVKTCWKGLQDLPHIANELKSKYLGATKvI 247 tropical clawe...
51_pfamImport 134 ----------rsGaQaVRL-MHLHNNAVGRQALVDAMETKCKCHGVSGSCSVKTCWKGLHDINDIAADLKSKYLAATKvI 202
O73864        180 ----------rsGpQdFRL-MQLHNNAVGRQVLMDSLEMKCKCHGVSGSCSVKTCWKGLQDISTISADLKSKYLSATKvI 248 zebrafish
XP_046450779  214 gghsgsavqhwkKpHvISA-VNMHNNRVGRKVAEQSLQTQCKCHGVSGSCQIKTCWRSLPPVGEIASRMKTLYGLAVE-V 291 common water flea
8TZO_A        239 epvraSRNKRP------TFLK--IKKplSY-RKPMD-----------------------------TD-LVYIEKSPNYCE 279 human
XP_015835988  280 s----RYYVEG------NL------------GKTRI-----------------------------SDhLLYLSKSPDYCT 308
XP_002434188  248 a----RHAPAGvggsphKIVP---VS--EHvGRLQK-----------------------------AD-LVYRTKSPDYCS 288
XP_031410500  245 sh--rLVGHRK------QLKP--TET--DI-RVMRD-----------------------------TD-LVYLINSPDYCT 281
XP_012400784  248 vh--rPMGNRK------HLVP--KDL--DI-RPVQD-----------------------------TE-LIYLQSSPDFCM 284
XP_005806753  252 y---rTMGTRK------HLVP--KDI--DV-RPLRE-----------------------------NE-MIYLHSSPDFCT 287
Q28J82        248 h---rQTGTRR------QLVP--REL--DI-RPVRE-----------------------------SE-LVYLVSSPDYCA 283 tropical clawe...
51_pfamImport 203 h---rHVGTRK------QLVP--REL--DV-RPVRE-----------------------------SE-LVYLISSPDYCM 238
O73864        249 p---rQIGTRR------QLVP--REM--EV-RPVGE-----------------------------NE-LVYLVSSPDYCT 284 zebrafish
XP_046450779  292 -----TPRRPN------DMRRrsAVA--SG---RLAmltaiqhhhpqappnlmastavrdggfneQD-LIYITKSPDFCR 354 common water flea
8TZO_A        280 EDPVTGSVGTQGRACNKT-APQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349 human
XP_015835988  309 KDVKLGSFGTVGRKCNVT-TNETNSCRQLCCGRGYRTLVEEKLERCHCKYYNCCYVKCKICRTKTQIYECG 378
XP_002434188  289 WDTRVGSLGTEGRTCNST-ESGTLGCDSMCCGRGYITLRKQVSERCHCRYHWCCFVECKTCSDWTLVDVCK 358
XP_031410500  282 PNVHLGSVGTQDRQCSKT-SAGSDGCDLLCCGRGYNAYMEEVVERCHCKYRWCCYVVCKRCRRLEERYVCK 351
XP_012400784  285 KNEKVGSHGTQDRQCNKT-SNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERIVERYVCK 354
XP_005806753  288 KNEKLGSVGTQDRQCNKT-SVGSDSCDLMCCGRGYNPYTELLVERCHCKYHWCCYVTCKKCERNVERYVCK 357
Q28J82        284 KNPKLGSYGTQDRVCNKT-SVGSDSCNLMCCGRGYNAYTETIVERCQCKYYWCCYVMCKKCERTVERYVCK 353 tropical clawed frog
51_pfamImport 239 KNEKHGSFGTQDRQCNKT-SNGSDSCNLMCCGRGYNAYTETVVERCQCKYHWCCYVTCKKCERTVERYVCK 308
O73864        285 QNAKQGSLGTTDRQCNKT-ASGSESCGLMCCGRGYNAYTEVLVERCQCKYHWCCYVSCKTCKRTVERYVSK 354 zebrafish
XP_046450779  355 PDKQSGSLGTAGRMCNAThESSSGSCASLCCGRGYITVIREQVERCNCKYIWCCTVRCKTCRRQVEMHMCK 425 common water flea
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