6TM2,6TM2,7PP6


Conserved Protein Domain Family
VWD

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pfam00094: VWD (This model is not part of the current CDD release)
von Willebrand factor type D domain
Luciferin 2-monooxygenase contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods. This domain is structurally homologous to the C-terminal domain of repulsive guidance molecules (RGM) despite low sequence identity.
Statistics
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PSSM-Id: 513142
Aligned: 43 rows
Threshold Bit Score: 95.5224
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6TM2_A  371 CALEGGSHITTFDGKTYTFHG----DC-----YYV--LAKGDHNDS-------YALLGeLAPCGSTDKQT--CLKTVVLL 430  human
O08523  713 CLLSQNQVLHTFDGAAYAFPS----EL-----SYT--LLKTCPERPey----lEIDIN-KKKPDAGPAW----LRGVRIL 772  house mouse
Q02817   37 CSTWGNFHYKTFDGDVFRFPG----LC-----DYN--FASDCRGSYke----fAVHLKrGPGQAEAPAG----VESILLT 97   human
Q62635   34 CSTWGDFHYKTFDGDVFRFPG----LC-----DYNfaSDCR-DSYKe-----fAVHLKrGLDKAGGHSS---IESVLITI 95   Norway rat
Q02817 4591 CTGWGDPHYVTFDGLYYSYQG----NC-----TYV--LVEEISPSVdn----fGVYIDnYHCDPNDKVS---CPRTLIVR 4652 human
Q9HC84 5075 CSMWGGSHYSTFDGTSYTFRG----NC-----TYV--LMREIHARFgn----lSLYLDnHYCTASATAAAarCPRALSIH 5139 human
P04275 1950 CTGSSTRHIVTFDGQNFKLTG----SC-----SYV--LFQNKEQDl-------EVILHnGACSPGARQG---CMKSIEVK 2008 human
O55225 2098 CSIFPDLSFVTFDGSHAALFK----EA-----IYV--LSQSPDETIs------VHVLDcKSANLGHLNWPpfCLVILNVT 2160 house mouse
P34501  854 GYIYGEPHVITYDGIRYTMPGkgyyVLtmsdsPYHklMVQVRLEQPddtlwhaHVNATvITGVAVQENDS--SIVQVYAR 931  Caenorhabditis elegans
6TM2_A   17 CSTWGNFHYKTFDGDVFRFPG----LC-----DYN--FASDCRGSYk------EFAVHlKRGPGQAEAPA--GVESILLT 77   human
6TM2_A  431 AD--------KKKNaVVFKS------DGSVLLNQLQVNLPHVTASF--SVFRPS--------SYhIMVSM----AIGVRL 482  human
O08523  773 VA--------DQEV-KIGGVg-----ALEVKLNGQDVELPFFHPSG--RLEIHR--------NK-NSTTV----ESKGVV 823  house mouse
Q02817   98 IK--------DDTI-YLTRH--------LAVLNGAVVSTPHYSPGL--LIEKSD--------AY-TKVYS----RAGLTL 145  human
Q62635   96 K---------DDTI-YLTH--------KLAVVNGAMVSTPHYSSGL--LIEKND--------AYt-KVYS----RAGLSL 142  Norway rat
Q02817 4653 HE--------TQEV-LIKTVhmm-pmQVQVQVNRQAVALPYKKYGL--EVYQSG---------InYVVDIp---ELGVLV 4708 human
Q9HC84 5140 YKsm----diVLTV-TMVHGk----eEGLILFDQIPVSSGFSKNGV--LVSVLG--------TTtMRVDIp---ALGVSV 5197 human
P04275 2009 HS--------ALSV-ELHSD-------MEVTVNGRLVSVPYVGGNM--EVNVYG--------AImHEVRFn---HLGHIF 2059 human
O55225 2161 HL--------AHHV-SIDRF------NRKVTVDSQVVWPPMSRYGF--RIEDTG---------HmYIVRT----PSHIQI 2210 house mouse
P34501  932 KPmrrwryrtDVYV-DGTRRffdkphWKHQQFKHLDIRNPLQNMNQseIVIMLKsgvgirifEGfGMLDVmvtlPPSYNT 1010 Caenorhabditis elegans
6TM2_A   78 IK--------DDTI-YLTR--------HLAVLNGAVVSTPHYSPGL--LIEKSD--------AYt-KVYS----RAGLTL 125  human
6TM2_A  483 Q-VQLAP-VMQLFVTLDQASQGQVQGLCGNFNGLEGDDFKTASGL 525  human
O08523  824 S-VQYSD-VGLLYIRLSTMYFNCTGGLCGFFNANASDEFCLPNGK 866  house mouse
Q02817  146 M-WNRED---ALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGV 186  human
Q62635  143 M-WNRED---ALMVELDGRFQNHTCGLCGDFNGMQANNEFLSDGI 183  Norway rat
Q02817 4709 S-YNGLS--FSVRLPYHRFG-NNTKGQCGTCTNTTSDDCILPSGE 4749 human
Q9HC84 5198 T-FNGQV--FQARLPYSLFH-NNTEGQCGTCTNNQRDDCLQRDGT 5238 human
P04275 2060 T-FTPQNnEFQLQLSPKTFA-SKTYGLCGICDENGANDFMLRDGT 2102 human
O55225 2211 QwLHSSG---LMILEASKVSKTQGHGLCGICDGDAANDLTLKDGS 2252 house mouse
P34501 1011 TcRPGESlSSSLNAPRGQRRCYTTLGLLGTYNNDPADDLTTPSGT 1055 Caenorhabditis elegans
6TM2_A  126 M-WNRED---ALMLELDTKFRNHTCGLCGDYNGLQSYSEFLSDGV 166  human
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