2WWO,6FN8


Conserved Protein Domain Family
Sod_Cu

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pfam00080: Sod_Cu (This model is not part of the current CDD release)
Copper/zinc superoxide dismutase (SODC)
superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.
Statistics
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PSSM-Id: 513129
Aligned: 360 rows
Threshold Bit Score: 50.2707
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2WWO_B                   32 AlGTVTVTe-----T-------AyGLL-FTPHltGLAP--G-IH-GFHLH----EK------PSCa--PGmkdgka-vpa 81   Yer...
PRJNA61269:NIASO_02640   80 NlGTAKFYkla-----------dgkIR-LDIEinMPERk-D-SNvAVHFH----EH------GDCgmkGEn--------- 126 
51_pfamImport             1 InGFVRFRqfeykdGstsdtflEvDLKhKGNYnrNITK--G-HRwSVFVN----QV------G-----ADafqtvesvrc 62  
56_pfamImport             1 AyGYIRFTqligndNsqsdttiEvKLRyPGKHdrNVTH--N-HSwNIWVN----PV------G-----VDatvpqvetrc 62  
EFN70893                729 VyGYIKMTqlvykdGsqsetviEvNLRhPGKHdrNITK--N-HNwAIYVN----PV------G-----VDatvkvkdtrc 790 
CCG84096                124 PyGFIEFVytsetsAr------------IEVRltNMPE--DrGPfSYHIHtdrvSEhitdppEQCka------------- 176 
4_pfamImport              1 VrGSVTIFpkpdsvG----------VL-VSAQfwGIPD--NdQQlVYHIH----QKpvp-qdGNCys------------- 49  
XP_003323773             58 VsGQIHFAlqpesnA----------VA-VSISinGLNAlnStAAyAYHIH----TNpis-sdGNCas------------- 108 
XP_014569507             95 IeGRVl---------------------------rGLND--StEY-RYHIH----TNpis-adGNCas------------- 126 
XP_001382774             46 VtGTVSFSaaq-----------ngsVL-VSVDlsGLPS--TgGPfPYHVH----EHpvp-tdGNCtg------------- 93  
2WWO_B                   82 laaGGHLDPnKT--------G-----VHLgpyn-------------dkgHLGDLP-GLvvNADGTATYP-VLAPR--LKs 131  Yer...
PRJNA61269:NIASO_02640  127 --sHGHWNP-TN--------A-----KHGewgs-------------asfHAGDIG-NIklDATGHGTKS-VTTDLwsVDa 175 
51_pfamImport            63 vasGYIWNPyQT--------------DSNkfpdlykrhc--tptnplrcvlGDLSgRNgpliiGGKRRV-ITDVN--LPl 123 
56_pfamImport            63 vaaGYVWNPyYT--------------QLAdplnhdlyrrecgpdnplrcyvGDVSaRLgpisiGSRRQV-FTDSN--FPl 125 
EFN70893                791 vagGYMWNPyFT--------------QLAdplnddlyrqecgpdlplrcyvGDISaRVgpiniGEKRQV-FTDQN--FPl 853 
CCG84096                177 --aKGHLDPaNVgeafvcdsEkkggcQAGdlt---------------gkY-GKIPaSIk---sSQVYKEvYDEKY--ISw 233 
4_pfamImport             50 --tGAHLDPyGRgdatpcdiNapqtcQVGdls---------------gkH-GPIW-----APDNEVFSTtYTDWF--LSn 104 
XP_003323773            109 --aLGHLDPlNVtdglvcnpQisqycQEGdls---------------srH-GKFNgS------ESTLNLaYIDDY--LRf 162 
XP_014569507            127 --aLGHLDPvSVtdyiacdpSqpwycQEGdls---------------gkH-GKLQgTVn----GNTPAFsFIDPY--VRf 182 
XP_001382774             94 --tLAHLNPfGGsv----naTdaagkEVGdla---------------gkH-GNIE--------GQSADLsYVDDY--LSl 141 
2WWO_B                  132 l----seVKQHALMIHAGGDNYsdHpmPLGGGGARMACGVI 168  Yersinia pseudotuberculosis
PRJNA61269:NIASO_02640  176 gn---kdIIGKAVIVHGGTDDYktQ--PSGNSGPRVGCGVI 211 
51_pfamImport           124 vgn--asvVGRSLIIYHKDESD-----------TKMACANI 151 
56_pfamImport           126 egt--vsaLGRSIVIFGPDFSG-----------HRFACANI 153 
EFN70893                854 ggs--vsaIGRSIVIYDKDFAS-----------NRFACANI 881 
CCG84096                234 kasdanffVNRSIVIHEASNK------------GRIACANI 262 
4_pfamImport            105 vegepaffGNLSLVVHAADN-------------SRLACGNF 132 
XP_003323773            163 wpq-pfsiLGRSVVVHLPNS-------------TRIACGNI 189 
XP_014569507            183 ypq-pfsiLGRSVVIHAPDL-------------TRVTCGNI 209 
XP_001382774            142 npdnkayiGGLSVVVHLLDN-------------TRIACANI 169 
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