Conserved Protein Domain Family
Insulin

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pfam00049: Insulin 
Insulin/IGF/Relaxin family
Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.
Statistics
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PSSM-Id: 484027
Aligned: 28 rows
Threshold Bit Score: 49.4048
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P04808        32 IKLCGRELVRAQIAIC---GMstw-skRsLSQEdAPq-TPRPVAEIVPsfinkdtetiiimlefianlppelkaalserq 106 human
NP_001118169  53 ETLCGGELVDALQFVC---ED------R-GFYFsRP--TSR--------------------------------------- 81 
P01348        31 IKACGRELVRLWVEIC---GSv----sW-GRt--ALsl-eePQLETGPpaetmpssitkdaeilkmmlefvpnlpqelka 99  pig
P01347        33 IQVCGRGYARAWIEVCg--ASv----gR-LAl---SqeepaPLARQATaevvpsfinkdaepfdmtlkclpnlseerkaa 102 Norway rat
P26733        26 RTYCGRHLADTLADLCf--GVe----kRgGAQY-APyfWTR--------------------------------------- 59  domestic silkworm
P26739        27 RTYCGRHLANILAYVCf--GVe----kRgGAQY-APy-WQE--------------------------------------- 59  domestic silkworm
P33721        24 RRYCGRVLADTLAYLC---PEmeevekRsGAQY-AR--YGW--------------------------------------- 58  ailanthus silkmoth
P15410        24 QFYCGDFLARTMSSLCw--SDmq---kRsGSQY-AGygWPW--------------------------------------- 58  domestic silkworm
P15411        26 HTYCGRHLARTMADLCw--EEgv--dkRsDAQF-ASygSAW--------------------------------------- 61  domestic silkworm
P26726        26 HTYCGRHLARTLANLCweaGVd----kRsDAQYv-SygSAW--------------------------------------- 61  domestic silkworm
P04808       107 ps-----lpelqqyvpalkdsnlsfeefkklirnrqseaaDSNPSELKYLGLD-THSQkk-rrPYVA--LFEKCCLIGCT 177 human
NP_001118169  82 ------------------------------------------------------SNSRr---sQNRG--IVEECCFRSCD 102
P01348       100 tlse-rqpslrelqqsaskdsnlnfeefkkiilnrqneaeDKSLLELKNLGLD-KHSRkkrlfRMT---LSEKCCQVGCI 174 pig
P01347       103 lsegrapfpelqqhapalsdsvvslegfkktfhnqlgeaeDGGPPELKYLGSD-AQSRk---kRQSGalLSEQCCHIGCT 178 Norway rat
P26733        60 ----------------------------------------------------QyLGSR-----GKRG--VVDECCFRPCT 80  domestic silkworm
P26739        60 ---------------------------------------------------TY-LRSRk----GP-G--VVDECCFRPCK 80  domestic silkworm
P33721        59 ----------------------------------------------------QsPESReg-arGKRG--VVDECCYNSCT 83  ailanthus silkmoth
P15410        59 -------------------------------------------------LPPF-SSSR-----GKRG--IVDECCYRPCT 81  domestic silkworm
P15411        62 -------------------------------------------------LMPY-SAGR--------G--IVDECCLRPCS 81  domestic silkworm
P26726        62 -------------------------------------------------LMPY-SEGR-----GKRG--IVDECCLRPCS 84  domestic silkworm
P04808       178 KRSLAKYC 185 human
NP_001118169 103 LNLLEQYC 110
P01348       175 RKDIARLC 182 pig
P01347       179 RRSIAKLC 186 Norway rat
P26733        81 LDVLLSYC 88  domestic silkworm
P26739        81 LEVLKSYC 88  domestic silkworm
P33721        84 LDVLLSYC 91  ailanthus silkmoth
P15410        82 IDVLMSYC 89  domestic silkworm
P15411        82 VDVLLSYC 89  domestic silkworm
P26726        85 VDVLLSYC 92  domestic silkworm
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