3GTU,3I6A,1B4P,2C4J,1AXD,1F3A,5JPO,1GSU,1GUK,1VF2,1U3I,4KGI,1NHY,6WMU,3R2Q,1M0U


Conserved Protein Domain Family
GST_C
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pfam00043: GST_C (This model is not part of the current CDD release)
Glutathione S-transferase, C-terminal domain
GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.
Links
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Statistics
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PSSM-Id: 513094
Aligned: 48 rows
Threshold Bit Score: 57.2878
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3GTU_B       107 VMDFRTQLIRLC----YSSDH-------------------------------EKLKPQYLEELPGQLKQFSMFLGKFS-- 149 human
P04907       107 FHPNASPLVFQL----LVRPLlg----------------------------gAPDAAVVEKHAEQLAKVLDVYEAHLArn 154 Zea mays
P12653       110 LNPILFQVLISP----MLGG--------------------------------TTDQKVVDENLEKLKKVLEVYEARLTkc 153 Zea mays
P30110       111 YYPAISPVVFEC----IIIPFiipg------------------------ggaAPNQTVVDESLERLRGVLGIYEARLEks 162 bread wheat
P0A9D2       100 YIATELHKGFTP----LFRPD--------------------------------TPEEYKPTVRAQLEKKLQYVNEALKde 143 Escherichia col...
P0ACA3       101 lYMHRIEKDWYT----LMNTIi------------------------------NGSASEADAARKQLREELLAIAPVFGqk 146 Escherichia col...
WP_014075191 107 FCWCVSTIGWAF----GIKAIaqkmsdeefeehinknvpipeqqlkwrrarnGFPQEMLDEEFRKVGVSVARLEETLSkq 182 Sphingobium sp....
1AXD_A       109 LNPILFQVLISP----MLGG--------------------------------TTDQKVVDENLEKLKKVLEVYEARLTkc 152 Zea mays
4KGI_A       122 YIATELHKGFTP----LFRPD--------------------------------TPEEYKPTVRAQLDKKLQYVNEALKde 165 Shigella flexne...
3R2Q_A        96 LADGIMDAGLVSvreqARPAA-------------------------------QQSEDELLRQREKINRSLDVLEGYLVdg 144 Escherichia col...

3GTU_B       150 -WFAGEKLTFVDF--LTYDILDQNRIFDPKCL-----DEFPNLKAFMCRFEALE 195 human
P04907       155 kYLAGDEFTLADAnhALLPALTSARPPRPGCV-----AARPHVKAWWEAIAARP 203 Zea mays
P12653       154 kYLAGDFLSLADL--NHVSVTLCLFATPYASVl----DAYPHVKAWWSGLMERP 201 Zea mays
P30110       163 rYLAGDSITFADL--NHIPFTFYFMTTPYAKVf----DDYPKVKAWWEMLMARP 210 bread wheat
P0A9D2       144 hWICGQRFTIADA--YLFTVLRWAYAVKLNL------EGLEHIAAFMQRMAERP 189 Escherichia coli K-12
P0ACA3       147 pYFLSDEFSLVDC--YLAPLLWRLPQLGIEFSg----PGAKELKGYMTRVFERD 194 Escherichia coli K-12
WP_014075191 183 dYLVDTGYSLADI--CNFAIANGLQRPGGFFGdyvnqEKTPGLCAWLDRINARP 234 Sphingobium sp. SYK-6
1AXD_A       153 kYLAGDFLSLADL--NHVSVTLCLFATPYASVl----DAYPHVKAWWSGLMERP 200 Zea mays
4KGI_A       166 hWICGQRFTIADA--YLFTVLRWAYAVKLNL------EGLEHIAAFMQRMAERP 211 Shigella flexneri 2a str. 2457T
3R2Q_A       145 -tLKTDTVNLATI--AIACAVGYLNFRRVAPGw---xVDRPHLVKLVENLFSRE 192 Escherichia coli K-12
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