1S6I,2AAO,2KYC,2BEC,2E30,1JBA,2GGZ,2NA0,2I94,2L2E,1FPW,2DOQ,1NCZ,4DS7,2LMT,2DOQ,2LMT,4DS7,2AAO,1S6I,2JPT,1CFP,2DOQ,1S6I,2AAO,1GGZ,2LMT,4DS7,2GGZ,2NA0,4OV2,2L2E,1FPW,1JBA,2AAO,1S6I,2LMT,4DS7,6XU4,2ROB,1GGZ,3OX6,2BEC,2E30,4IL1,5JOL,2GGZ,1JBA,2NA0,2I94,1FPW,2L2E,5JOL,5JJG,5JJG


Conserved Protein Domain Family
EF-hand_1
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pfam00036: EF-hand_1 
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EF hand
The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.
Links
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Statistics
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PSSM-Id: 425435
Aligned: 564 rows
Threshold Bit Score: 25.439
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1S6I_A  11 GLKELFKMIDTDNSGTITFDELKDGLKRV 39  soybean
P34368  87 VVQAVMRSSDVSGDGQIDFEEFLAAVTSK 115 Caenorhabditis elegans
P10463  61 EAEGVCRRWDRDGSGTLDLEEFLRALRPP 89  dog
P40421 570 EMLEKCRMMDLNGDGKVDLNEFLEAFRLS 598 fruit fly
O14829 610 QVNKLANIMDLNKDGSIDFNEFLKAFYVV 638 human
O35385 700 GICDLARSIDFNKDGHIDINEFLEAFRLV 728 house mouse
P93759 395 DIQILMDAGDVDKDGYLDVNEFVAISVHI 423 thale cress
2GGZ_B  58 HIDQVYNTFDTNKDGFVDFLEFIAAVNLI 86  human
1JBA_A  60 YVEAMFRAFDTNGDNTIDFLEYVAALNLV 88  cattle
2NA0_A  55 YVEQMFETFDFNKDGYIDFMEYEAALSLV 83  cattle
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