Conserved Protein Domain Family
Connexin

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pfam00029: Connexin (This model is not part of the current CDD release)
Connexin
Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.
Statistics
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PSSM-Id: 513080
Aligned: 169 rows
Threshold Bit Score: 156.53
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4T8N8          3 EWTLLKRLLDAVHQHSTMIGRLWLTVMVIFRLLVVAVATEDVYTDEQEMFVCNTLQPGCSTVCYDAFAPISQPRFWVFHI 82  spotted green ...
28_pfamImport   1 AWHIVQKLVEGVGEHSTLFGKFWITLFFIIRFLFVVTLAESTWTDNESGIVCNTLSPGCKNVCFNAFSPISPIRYWCFQL 80 
XP_069040377    3 DWSILGRFLTEVQNHSTVIGKIWLTMLLIFRILLVTLVGDAVYSDEQSKFTCNTLQPGCNNVCYDTFAPVSHLRFWVFQI 82 
XP_005997054    3 DWSILGRLLTEVQNHSTVIGKIWLTMLLIFRILLVTLVGDAIYSDEQSKFTCNTLQPGCNNVCYDTFAPVSHLRFWVFQI 82 
55_pfamImport   1 DWSFLGRLLTQVQNHSTVVGKVWLTVLLVFRILLVTLVGDAVYGDEQSKFTCNTLQPGCTNVCYDRFSPVSHFRFWVFQI 80 
48_pfamImport   1 KLGFLSSVLCKWHAQATLIGKYLLPVLLLIRFVMLGAAVQTAWLNDREEFLCSTQQPGCETACFDAVTPLSLPRLWTLQL 80 
49_pfamImport   1 EESVLSRLLALWHSHAGFLGKTVLPVLQLVRIVLVGAAVQPVW--SNDYFVCDTNQPGCSSAAYNAVFPFSVHQYWTLQV 78 
XP_001376543    3 DWSFLGRLLNEVQNHSTVIGKIWLTALLIFRILLVTLVGDAIYGDEQSKFTCNTLQPGCTNVCYNSFAPISHLRFWIFQI 82  gray short-tai...
XP_026691633      --------------------------------------------------------------------------------     vase tunicate
XP_002131483    2 AWHIVEKLLEQVAEHSTLVGKFWVTFFFVLRFLMVVSIADTVFGDEQGSFVCNTLTPGCANICFNDFSPISLIRLWALQI 81  vase tunicate
Q4T8N8         83 ISVSTPSLCFII--YTWHNLSKVHS---AAQrhprgagqplgqdvgqaakevlgkeagkaggdreVYPPSCSSDS----- 152 spotted green ...
28_pfamImport  81 LATALPPIMIAVslHFIYKSFQREQs--FAW----------------------------------KNXYFDIEIV----- 119
XP_069040377   83 VLVSTPSIFYIV--YVLHKIAKDEKl-eSGQ----------------------------------AQAAVQGGQE----- 120
XP_005997054   83 VLVSTPSIFYII--YILHKIAKDEK-----------------------------------------REVEKVYMQ----- 114
55_pfamImport  81 VLVATPSIFYVI--YVLHQIAREERvdmEREyl-------------------------------lDTLRKLASGG----- 122
48_pfamImport  81 VLVLAPGLVFLC--YLIHLTNQETQ-------------------------------------------------V----- 104
49_pfamImport  79 VFVLAPGLIYLF--VRFLSPLFLHQ------------------------------------------------------- 101
XP_001376543   83 VLVATPSIFYIV--CVLHQVALEER---MDVerdrllelwrr------------lvpatgevlpgVGSGVLVPSS----- 140 gray short-tai...
XP_026691633      --------------------------------------------------------------------------------     vase tunicate
XP_002131483   82 LSVSLPTIIFMV--YTAHKMTKISQa--KKL----------------------------------RQDEMDKKKKmreea 123 vase tunicate
Q4T8N8        153 --CSVLSHK----HLGHslvdild-------------------------------gvaarslRngdpatsrpiqaytfkd 195 spotted green ...
28_pfamImport 120 --KQNTQFL----------------------------------------------------------------------- 126
XP_069040377  121 --PDVGEPGepggGGPSsrceeew-------------------------------nlriangVeqtllgedi---gevsk 164
XP_005997054  115 --RLPTDQRl--qEELGlsqrlds-------------------------------fetqmvtSngedeqqil---gndik 156
55_pfamImport 123 --ALQRPKLgllaSSHFlegqllv-------------------------------gervlpkClgaaa-----------r 158
48_pfamImport 105 --QRGNDEV----------------------------------------------------------------------- 111
49_pfamImport 102 ---SETGTV----------------------------------------------------------------------- 107
XP_001376543  141 --SFEGHSL----DEEEvlpkhlq-------------------------------stsqdpiY----------------- 166 gray short-tai...
XP_026691633    1 -------mnrylgVRTAnkrwkvl-------------------------------tnhvipsElh--------------- 27  vase tunicate
XP_002131483  124 kkLKEEARKkamadrrrrleesgppdynalendafvtdvkknekkekepekdkdddkvvatkLds--------------- 188 vase tunicate
Q4T8N8        196 gsseGlavSGGVLSKcYIFHVCLRAALEVGFVAAQWKLF--GLQVPVRFLCTSSPCNQPVDCYVSRPTEKTIFLIFMFCV 273 spotted green ...
28_pfamImport 127 --------HGKYILT-YGSKVFMRLVIEVGFMVGQYFLYtyKFVVPELWQCSHWPCPNVVDCFVSRPKEKTIQTCIFYVT 197
XP_069040377  165 dpthL---SSKVLLI-YIVHVVLRSLMEIGFLVGQYYLY--GFEVPHLFRCETYPCPNRTDCFVSRATEKTIFLNFMFGV 238
XP_005997054  157 dptqL---SDKVLII-YIVHVILRSVMEVVFLVGQFYLY--GFEVPHLFRCQTYPCPTRTDCFVSRATEKTIFLNFMFGV 230
55_pfamImport 159 npglR---SQRVLAI-YIAHVVLRAFMELAFLVGQYYLF--GFDVPYLFHCHSYPCPTSTDCFVSRATEKMIFLNFMFGV 232
48_pfamImport 112 --------KGHTLSV-YRACMAFVIVVEVGCSAAQWCLY--GFELSTDFSCGRSPCPMRVDCFLSHAWEKTVFLRIMFTA 180
49_pfamImport 108 ----I---KRQSLWA-YLGFLSAVVLLELGFAVGQCLKF--GLFLPPMFNVAVSPCPHTVDCFLSQPNEKSVFMFIMLVL 177
XP_001376543  167 ----L---ANRALII-YIAHVVLRAFLELGFLVGQYYLF--GFDVPHLYRCETYPCPTKTDCFVSRATEKMIFLNFMFGV 236 gray short-tai...
XP_026691633   28 ---kT---RGQCIWRlYLLQIFSRMLIECVFIMLQYTVYfyRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVI 101 vase tunicate
XP_002131483  189 ---dT---PSRLMLA-YVVQVVCRLAVEIGFMVLQFNIYvfKFWVPELFKCARWPCPNVVDCFVSRPKEKTIMLWVMFAT 261 vase tunicate
Q4T8N8        274 GVFCIFLNLLELNHLGW 290 spotted green pufferfish
28_pfamImport 198 GCIMVVLNVIELYHIGG 214
XP_069040377  239 SLGCFVLNIVELHYLGW 255
XP_005997054  231 SLGCFLLNIVELHYLGW 247
55_pfamImport 233 GVGCFLLNLVELHYLGW 249
48_pfamImport 181 SSVSILLNVVEAVCMLR 197
49_pfamImport 178 ACLSGLLTLVEMCTVMK 194
XP_001376543  237 GLGCFLLNLAELHYLGW 253 gray short-tailed opossum
XP_026691633  102 SAFSILLSIGELLYIGW 118 vase tunicate
XP_002131483  262 GLIMIVLNLIELYHLGA 278 vase tunicate
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