1OT8,6IF3,8JE2,1IHB,1BI8,7ROY,1AWC,1BI8,1IHB,1QYM,6LBF,1BI8,1IHB,7ROY


Conserved Protein Domain Family
Ank
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pfam00023: Ank (This model is not part of the current CDD release)
Ankyrin repeat
Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Links
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Statistics
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PSSM-Id: 513074
Aligned: 1059 rows
Threshold Bit Score: 24.545
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1OT8_C    1 MGLTPLM-IAAv---RGGgldtgediennedstAQVISD---LLaQ--Ga-E---LnATMDK 49   fruit fly
Q9ZT78  246 GGRSIVH-AALk---ANR---------------KDILDA---LLsK--D--As--LiNLRDE 279  thale cress
Q9ZT76  313 GRKSLLH-AALk---AKN---------------TDVLNV---ILnD--D--Ps--LvNERDE 346  thale cress
P95546   41 QLRTLFF-DASregnNP------------------MLDT---FI----E--AhydL-NIRDE 73   Pseudomonas syringae pv. syringae
P70770   33 DNNNALW-FACf---GNH---------------YDLIHL---LL-A--Ak-In--I-DNQND 65   Anabaena sp.
Q21920  361 ERDSALT-LSAq---KG------------------HIKIvtaIM-DyyE--Kn--P--PQTE 393  Caenorhabditis elegans
O14593  156 ERESALS-LASt---gGY---------------TDIVGL---LLeR--D--Vd--I-NIYDW 188  human
Q21920  402 ERYSALMeAAM----EGH---------------IDVCKL---MLsR--Gt----pA-DLCTE 434  Caenorhabditis elegans
Q21920  667 DGVNCFM-EVAr---HGS---------------IDLMSL---LV-E--FtkGn--M-PMDKD 700  Caenorhabditis elegans
Q9ZCL2   69 DNSSLFI-RACe---HLR---------------KDIITL---LL-D--Hg-Ad--P-MATND 101  Rickettsia prowazekii
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