2DZO,5Y4E,1N11,5Y4E,6EMK,5D68,6MEW,1N11,6JD6,1K1A,4OT9,1K3Z,2DZO,1N11,1N11,1N11,1N11,1N11,1N11,1NFI,5Y4E,1N11,5Y4E,1N11,1N11,3NBN,3J5P,5JHQ,3C5R,5JA4,5Y4E,4OAU,5AAR,4OAU,5JHQ,6JD6,5JHQ,7JUP,6MEW,5D68,6TLH,5YBU,4OT9,1K3Z,6EMK,7JUP,1K3Z,1NFI,6EMK,1K1A,2FO1,4OAU,1K1A,4OAU,2FO1,5YBU,6TLH,5YBU,1K3Z,5AAR,1NFI,1K1A,4OT9,5JHQ,2DZO,3DEO,5YBU,6TLH,5YBU,6JD6,4OAU,5JA4,2FO1,5H2C,6MEW,5H2C,3C5R,2DZO,2FO1,4OT9,6EMK,7JUP,5AAR,6JD6,5JHQ,5JHQ,5JHQ,5Y4E,5JHQ,3J5P,4OAU,3C5R,4OAU,3DEO,4OAU,7JUP,1K3Z,1K1A,4OT9,3J5P,1NFI,6GHM,5JA4,1K1A,1IHB


Conserved Protein Domain Family
Ank

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pfam00023: Ank 
Click on image for an interactive view with Cn3D
Ankyrin repeat
Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Statistics
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PSSM-Id: 459634
Aligned: 1062 rows
Threshold Bit Score: 26.8683
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DZO_C   71 SGWTPFHIACs---vGNLEVVKSLYd-RplkpD-LNKITN 105  baker's yeast
Q01484  562 KGFTPLHVAAk---yGSLDVAKLLLqrRa---AaDSAGKn 595  human
1N11_A  145 KGFTPLHVAAk---yGKVRVAELLLerDa---HpNAAGKn 178  human
O70511  572 KGFTPLHVAAk---yGKLEVASLLL--Qks-aS-PDAAGK 604  Norway rat
Q17343  226 SGFTPLHIAAhygheN---VGQLLLekGa---N-VNYQAR 258  Caenorhabditis elegans
P16157  205 TGFTPLHIAAhyenlN---VAQLLLnrGa---S-VNFTPQ 237  human
Q01484  595 NGLTPLHVAAhydnqK---VALLLLekGa---S-PHATAK 627  human
Q17343  589 NQVTPLHV-Aah--yNNDKVAMLLLe-Ng--aS-AKAAAK 621  Caenorhabditis elegans
Q01484  232 SGFTPLHIAAhygnvN---VATLLLnrGa---A-VDFTAR 264  human
Q25338  773 EGYTSLHIAAmrkepE---IAVVLIenGa---D-IEARSA 805  black widow
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