7BTS,7VL8,8XIO,5WB1,8IC0,7RKX


Conserved Protein Domain Family
7tm_1
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pfam00001: 7tm_1 (This model is not part of the current CDD release)
7 transmembrane receptor (rhodopsin family)
This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.
Links
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Statistics
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PSSM-Id: 513053
Aligned: 69 rows
Threshold Bit Score: 111.62
Created: 12-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7BTS_A 192 GNVLVIVAIAKTPRLQT-LT--NLFIMSLASADLVMGLLVVPFGATIVVw-GRWEYGSFF--CELWTSVDVLCVTASIET 265 synthetic construct
P60015  51 LNAMVLVATLRYKKLRQ-PL--NYILVNVSFGGFLLCIFSVFPVFVASCn-GYFVFGRHV--CALEGFLGTVAGLVTGWS 124 chimpanzee
P06002  67 GNGVVIYIFATTKSLRT-PA--NLLVINLAISDFGIMITNTPMMG-INLyfETWVLGPMM--CDIYAGLGSAFGCSSIWS 140 fruit fly
P04950  75 GNGLVIWVFSAAKSLRT-PS--NILVINLAFCDFMMM-VKTPIFIYNSFh-QGYALGHLG--CQIFGIIGSYTGIAAGAT 147 fruit fly
P30954  52 GNIIIVTIIRMDLHLHT-PM--YFFLSMLSTSETVYTLVILPRMLSSLVg-MSQPISLAG--CATQMFFFVTFGITNCFL 125 human
P34987  22 GNLLIILAVSSNSHLHN-LM--YFFLSNLSFVDICFISTTIPKML-VNIhsQTKDISYIE--CLSQVYFLTTFGGMDNFL 95  Norway rat
P37067  41 TNLGLIALISVDLHLQT-PM--YIFLQNLSFTDAAYSTVITPKMLATFLe-ERKTISYVG--CILQYFSFVLLTVTESLL 114 chicken
P23275  41 GNLTIILLSRLDARLHT-PM--YFFLSNLSSLDLAFTTSSVPQML-KNLwgPDKTISYGG--CVTQLYVFLWLGATECIL 114 house mouse
P35408  34 GNLVAIVVLCKSRKEQK-ETtfYTLVCGLAVTDLLGTLLVSPVTIATYMk-GQWPGGQPL--CEYSTFILLFFSLSGLSI 109 human
Q6SW98  50 NAIVLITQLLTNRVLGYsTP--TIYMTNLYSTNFLTL-TVLPFIVl----sNQWLLPASVasCKFLSVIYYSSCTVGFAT 122 Human herpesvirus 5 s...

7BTS_A 266 LCVIALDRYLAITSPFRYqsLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEarrcyNDPKCCDFVTN------- 338 synthetic construct
P60015 125 LAFLAFERYIVICKPFGNfrFSS-KHALTVVLATWTIGIGVSIPP-FFG-WSRFIPE-----GLQCSCGPDWYtvgt--- 193 chimpanzee
P06002 141 MCMISLDRYQVIVKGMAGr-PMTIPLALGKIAYIWFMSSIWCLAPAF--GWSRYVPE-----GNLTSCGIDYLerd---- 208 fruit fly
P04950 148 NAFIAYDRFNVITRPMEG--KMTHGKAIAMIIFIYMYATPWVVACYTET-WGRFVPE-----GYLTSCTFDYLtdn---- 215 fruit fly
P30954 126 LTAMGYDRYVAICNPLRYmvIMNKRLRIQLVLGACSIGLIVAITQVTSVFRLPFCARk----VPHFFCDIRPVmklsci- 200 human
P34987  96 LTLMACDRYVAICHPLNYtvIMNLQLCALLILMFWLIMFCVSLIHVLLMNELNFSRGt---eIPHFFCELAQVlkvansd 172 Norway rat
P37067 115 LAVMAYDRYVAICKPLLYpsIMTKAVCWRLVESLYFLAFLNSLVHTSGLLKLSFCYSn---vVNHFFCDISPLfqiss-- 189 chicken
P23275 115 LVVMAFDRYVAVCRPLHYmtVMNPRLCWGLAAISWLGGLGNSVIQSTFTLQLPFCGHr---kVDNFLCEVPAMiklac-- 189 house mouse
P35408 110 ICAMSVERYLAINHAYFYshYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQ-------YPDTWCFIDWTtnvt--- 179 human
Q6SW98 123 VALIAADRYRVLHKRTYA--RQSYRSTYIILLLTWFAGLIFSMPAAVYTTVVIHNGTngqssNGHATCVLYFIadevytv 200 Human herpesvirus 5 s...

7BTS_A 339 -----RAYAIASSVVSFYV-PLCIMAFVYLRVFREAQKQVKKIDS--------------------------------VAL 380 synthetic construct
P60015 194 -kyrsESYTWFLFIFCFIV-PLSLICFSYTQLLRALKAVAAQQQ---------------------------------ESA 238 chimpanzee
P06002 209 --wnpRSYLIFYSIFVYYI-PLFLICYSYWFIIAAVSAHEKAMRE--------------------------------QAK 253 fruit fly
P04950 216 --fdtRLFVACIFFFSFVC-PTTMITYYYSQIVGHVFSHEKALRD--------------------------------QAK 260 fruit fly
P30954 201 dttvnEILTLIISVLVLVV-PMGLVFISYVLIISTILKIASVEGR--------------------------------KKA 247 human
P34987 173 thinnVFMYVVTSLLGLI--PMTGILMSYSQIASSLLKMSSSVSK--------------------------------YKA 218 Norway rat
P37067 190 ssiaiSELLVIISGSLFVMsSIIIILISYVFIILTVVMIRSKDGK--------------------------------YKA 237 chicken
P23275 190 gdtslNEAVLNGVCTFFTVvPVSVILVSYCFIAQAVMKIRSVEGR--------------------------------RKA 237 house mouse
P35408 180 --ahaAYSYMYAGFSSFLIlATVLCNVLVCGALLRMHRQFMRRTSlgteqhhaaaaasvasrghpaaspalprlsdfRRR 257 human
Q6SW98 201 llswkVLLTLVWGAA-----PVIMMTWFYAFFYSTVQRASQKQRS----------------------------------- 240 Human herpesvirus 5 s...

7BTS_A 381 REQ-----------------KALKTLGIIMGVFTLCWLPFFLANVVKAFh---------rELVPDRLFVFFNWLGYANSA 434 synthetic construct
P60015 239 TTQka-------------erEVSRMVVVMVGSFCVCYVPYAAFAMYMVNnr--------nHGLDLRLVTIPSFFSKSACI 297 chimpanzee
P06002 254 KMNvkslrsse-daeksaegKLAKVALVTITLWFMAWTPYLVINCMGLFk---------fEGLTPLNTIWGACFAKSAAC 323 fruit fly
P04950 261 KMNveslrsnvdknketaeiRIAKAAITICFLFFCSWTPYGVMSLIGAFgd--------kTLLTPGATMIPACACKMVAC 332 fruit fly
P30954 248 FA------------------TCASHLTVVIVHYSCASIAYLKpk---------------sENTREHDQLISVTYTVITPL 294 human
P34987 219 FS------------------TCGSHLCVVSLFYGSATIVYFCSSVLHST---------------HKKMIASLMYTVISPM 265 Norway rat
P37067 238 FS------------------TCTSHLMAVSLFHGTVIFMYLRPVKLFSL---------------DTDKIASLFYTVVIPM 284 chicken
P23275 238 FN------------------TCVSHLVVVFLFYGSAIYGYLLpa---------------kSSNQSQGKFISLFYSVVTPM 284 house mouse
P35408 258 RSFrria---------gaeiQMVILLIATSLVVLICSIPLVVRVFVNQLyqp-----sleREVSKNPDLQAIRIASVNPI 323 human
Q6SW98 241 --------------------RTLTFVSVLLISFVALQTPYVSIMIFNSYataawpmdcehLTLRRTIGTLSRLVPHLHCL 300 Human herpesvirus 5 s...

7BTS_A 435 FNPIIY 440 synthetic construct
P60015 298 YNPIIY 303 chimpanzee
P06002 324 YNPIVY 329 fruit fly
P04950 333 IDPFVY 338 fruit fly
P30954 295 LNPVVY 300 human
P34987 266 LNPFIY 271 Norway rat
P37067 285 LNPLIY 290 chicken
P23275 285 VNPLIY 290 house mouse
P35408 324 LDPWIY 329 human
Q6SW98 301 INPILY 306 Human herpesvirus 5 strain Merlin
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