Conserved Protein Domain Family

cl41763: ELD_TRPML Superfamily 
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)
TRPML family proteins contain a linker between the first two transmembrane helices (S1 and S2), which is called TRPML I-II linker. It forms a tight tetramer that is crucial for full-length TRPMLs assembly and localization. In lysosomes and endosomes, this linker faces the lumen (it is therefore also referred to as the 'luminal linker'); on the plasma membrane, it faces the extracellular solution. TRPML I-II linker has been named as extracytosolic/lumenal domain (ELD).
Accession: cl41763
PSSM Id: 425394
Created: 24-Nov-2020
Updated: 24-Nov-2020
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