Conserved Protein Domain Family

cl41761: FIX-like Superfamily 
Found in type sIX effector (FIX) domain of unknown function
This family contains the Found in type sIX effector (FIX) domain and similar proteins. FIX is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. FIX is present in various established T6SS-secreted effectors that have an N-terminal VgrG or PAAR or PAAR-like (i.e., DUF4280) domain, suggesting that FIX may play a role in delivery of T6SS effectors, and serve as a new marker for T6SS-delivered proteins to enable the identification of novel T6SS substrates.
Accession: cl41761
PSSM Id: 425392
Name: FIX-like
Created: 24-Nov-2020
Updated: 24-Nov-2020
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