Conserved Protein Domain Family

cl41733: Syt1_2_N Superfamily 
N-terminal domain of synaptotagmin-1 and -2
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse. In general, synaptotagmins contain 2 calcium binding C2 domains. Synaptotagmin-1 and -2 have an additional N-terminal domain that has been shown to bind to Botulinum neurotoxin B.
Accession: cl41733
PSSM Id: 425364
Name: Syt1_2_N
Created: 24-Nov-2020
Updated: 24-Nov-2020
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