Conserved Protein Domain Family

cl41719: capping_2-OMTase_viral Superfamily 
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase
Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Some dsDNA and dsRNA viruses, like the bluetongue virus (BTV), a member of the Reoviridae family, and Vaccinia virus, a member of the Poxviridae family, as well as some ss(+)RNA viruses, like Flaviviridae and Nidovirales, cap their mRNAs and encode their own 2'OMTase. In BTV, all four reactions are catalyzed by a single protein, VP4. In Vaccinia, the activity is located in the processing factor of the poly(A) polymerase, VP39.
Taxonomy: root
PubMed: 26 links
Protein: Related Protein
Related Structure
Accession: cl41719
PSSM Id: 477759
Name: capping_2-OMTase_viral
Created: 24-Nov-2020
Updated: 4-Oct-2023
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