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Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 An alpha helical domain related to the alpha-helical DNA glycosylases, predicted to catalyze the in situ synthesis of hypermodified bases such as alpha-glutamyl, putrescinyl thymine, 5-(2-aminoethoxy)methyluridine or 5-(2-aminoethyl)uridine. The enzyme is predicted to utilize a high-energy pyrophosphate DNA base intermediate which is subject to a nucleophilic attack by the modifying moiety. Mainly found in caudoviruses and prophages. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",