This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilization. This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.
Jiyao W et al.(2023). "The conserved domain database in 2023.",