Conserved Protein Domain Family

cl29215: LeuA_dimer Superfamily 
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LeuA allosteric (dimerization) domain
This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyzes the first committed step in the leucine biosynthetic pathway. This domain, is an internally duplicated structure with a novel fold. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich.
Accession: cl29215
PSSM Id: 421756
Name: LeuA_dimer
Created: 19-Sep-2018
Updated: 24-Nov-2020
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