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carotenoid 1,2-hydratase and similar proteins Carotenoid 1,2-hydratase (EC 4.2.1.131; CrtC; also known as acyclic carotenoid 1,2-hydratase, 1-hydroxyneurosporene hydratase, hydroxylycopene hydratase, hydroxyneurosporene synthase, lycopene hydratase, or neurosporene hydratase) is an enzyme with the systematic name lycopene hydro-lyase (1-hydroxy-1,2-dihydrolycopene-forming). It is involved in the biosynthesis of carotenoids such as lycopenes. It catalyzes the hydration of neurosporene to the corresponding hydroxylated carotenoids 1-HO-neurosporene and that of lycopene to 1-HO-lycopene. Studies suggest that CrtC may be bound to the membrane through an anchor so that a close distance to the substrate, which is synthesized in the cell membranes, is facilitated. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",