Conserved Protein Domain Family

cl27780: UL141 Superfamily 
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Herpes-like virus membrane glycoprotein UL141
UL141 is a family of glycoproteins from herpesvirus species. At it N-terminus it carries an Ig-like beta-sandwich domain, which binds to the cysteine-rich region of TRAIL-R2, a family of tumor necrosis factor receptor proteins. UL141 is both necessary and sufficient to retain TRAIL receptors in the ER, thereby preventing their cell surface expression and it is also necessary and sufficient to inhibit cell surface expression of CD155.
Accession: cl27780
PSSM Id: 421546
Name: UL141
Created: 5-Dec-2016
Updated: 24-Nov-2020
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