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MgrB protein The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive promoter. Deletion of mgrB results in a potent increase in PhoP-regulated transcription. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC. |
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Jiyao W et al.(2023). "The conserved domain database in 2023.",