Conserved Protein Domain Family

cl23882: Holin_SPP1 Superfamily 
SPP1 phage holin
This family constitutes holin proteins from the dsDNA Siphidoviridae group bacteriophages with two transmembrane segments. Most bacteriophages require an endolysin and a holin for host lysis. During late gene expression, holins accumulate and oligomerise in the host cell membrane. They then suddenly trigger to permeablise the membrane, which causes lysis by allowing endolysin to attach the peptidoglycan. There are thought to be at least 35 different families of holin genes.
Taxonomy: root
PubMed: 2 links
Protein: Related Protein
Related Structure
Accession: cl23882
PSSM Id: 420075
Name: Holin_SPP1
Created: 2-Feb-2016
Updated: 4-Oct-2023
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