Conserved Protein Domain Family

cl22420: Hip_N Superfamily 
N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this model characterizes the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP.
Accession: cl22420
PSSM Id: 419827
Name: Hip_N
Created: 5-Sep-2014
Updated: 24-Nov-2020
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