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N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this model characterizes the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",