Conserved Protein Domain Family

cl13934: Inhibitor_I10 Superfamily 
Serine endopeptidase inhibitors
This family includes both microviridins and marinostatins. It seems likely that in both cases it is the C-terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. it is the ester linkages within the key, 12-residue. region that circularize the molecule giving it its inhibitory conformation.
Accession: cl13934
PSSM Id: 417412
Name: Inhibitor_I10
Created: 20-Jan-2010
Updated: 24-Nov-2020
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