Conserved Protein Domain Family

cl12130: Bacteriocin_IId Superfamily 
Bacteriocin class IId cyclical uberolysin-like
Members of this family are membrane-interacting peptides, produced by Firmicutes that display a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. They adopt a helical structure, with four or five alpha helices forming a Saposin-like fold. The structure has been found to be cyclical. It should be pointed out that one reference implies that both circularin A and gassericin A are class V or IIc-type bacteriocins; however we find that these two proteins fall into different Pfam families families, this one and BacteriocIIc_cy, pfam12173.
Accession: cl12130
PSSM Id: 416442
Name: Bacteriocin_IId
Created: 20-Jan-2010
Updated: 24-Nov-2020
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