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Inorganic H+ pyrophosphatase The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organizms as disparate as thermophilic Archaea and parasitic protists.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",