Conserved Protein Domain Family

cl11396: Patatin_and_cPLA2 Superfamily 
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Patatins and Phospholipases
Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates. This family also includes the catalytic domain of cytosolic phospholipase A2 (PLA2; EC hydrolyzes the sn-2-acyl ester bond of phospholipids to release arachidonic acid. At the active site, cPLA2 contains a serine nucleophile through which the catalytic mechanism is initiated. The active site is partially covered by a solvent-accessible flexible lid. cPLA2 displays interfacial activation as it exists in both "closed lid" and "open lid" forms.
Taxonomy: root
PubMed: 38 links
Protein: Related Protein
Related Structure
Accession: cl11396
PSSM Id: 416256
Name: Patatin_and_cPLA2
Created: 29-May-2009
Updated: 24-Nov-2020
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