?
HWE histidine kinase Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria. The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as pfam00512 and pfam07568. The family was defined by the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to pfam02518. It has been demonstrated to show structural and functional correlation with pfam07568. These proteins are found in a variety of alpha- and gamma- proteobacteria, with significant enrichment in the rhizobia.
|
Jiyao W et al.(2023). "The conserved domain database in 2023.",