Conserved Protein Domain Family

cl03445: V35-RBD_P-protein-C_like Superfamily 
C-terminal RNA-binding domain (RBD) domain of Ebola virus VP35 phosphoprotein and related proteins
This family includes the C-terminal RNA-binding domain (RBD) of the P protein of viruses belonging to the Filoviridae family, such as Ebola virus or Marburg virus. VP35-RBD contains two subdomains: an alpha-helical subdomain and a beta-sheet subdomain. Virus infection typically activates host innate immunity, including the interferon (IFN) signaling pathway; VP35-RBD binds double-stranded RNA (dsRNA) inhibiting IFN-alpha/beta signaling. The family Filoviridae belongs to the order Mononegavirales which are nonsegmented negative-stranded RNA viruses (NNVs). The genomes of NNVs are encapsidated by their nucleocapsid (N) proteins to form N-RNA complexes which serve as a template for transaction and replication. The C-terminus of P protein binds nucleocapsid. P protein plays multiple roles in transcription and translation, which include acting as a chaperone of nascent nucleoprotein (N), and as a cofactor of the viral polymerase (L) where P forms a two-subunit polymerase with a large catalytic subunit (L) and stabilizes the polymerase on its template of N-RNA.
Taxonomy: root
PubMed: 16 links
Protein: Related Protein
Related Structure
Accession: cl03445
PSSM Id: 413697
Name: V35-RBD_P-protein-C_like
Created: 8-Feb-2008
Updated: 24-Nov-2020
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