 |
?cl03019: VSV_P-protein-C_like Superfamily
C-terminal domain of Vesicular stomatitis Indiana virus phosphoprotein and related proteins This family includes the C-terminal domain of the P protein of plant viruses belonging to the Rhabdoviridae animal family such as Vesicular stomatitis Indiana virus (VSV). The family Rhabdoviridae belongs to the order Mononegavirales which are nonsegmented negative-stranded RNA viruses (NNVs). The genomes of NNVs are encapsidated by their nucleocapsid (N) proteins to form N-RNA complexes which serves as a template for transaction and replication. The C-terminus of P protein binds nucleocapsid. P protein plays multiple roles in transcription and translation, which include acting as a chaperone of nascent nucleoprotein (N), and as a cofactor of the viral polymerase (L) where P forms a two-subunit polymerase with a large catalytic subunit (L) and stabilizes the polymerase on its template of N-RNA. |
|
|
|
|
 |
Jiyao W et al.(2023). "The conserved domain database in 2023.",