Conserved Protein Domain Family

cl00113: CRIB Superfamily 
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.
Accession: cl00113
PSSM Id: 412170
Name: CRIB
Created: 8-Feb-2008
Updated: 24-Nov-2020
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