3HHD,2QO3,2HG4


Conserved Protein Domain Family
PKS_KS

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smart00825: PKS_KS 
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Beta-ketoacyl synthase
The structure of beta-ketoacyl synthase is similar to that of the thiolase family and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.
Statistics
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PSSM-Id: 214836
View PSSM: smart00825
Aligned: 2106 rows
Threshold Bit Score: 241.079
Threshold Setting Gi: 226945024
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HHD_A          6 VVIAGMSGKLPE-SENLQEFWDNLIGGvdmvtdddrrwk------------aglyglprrsgkLKDLSRFDASFFGVHPK 72   human
XP_001221381   16 IAIVGSACRFPGgVSSSSELWDLLRQPrdvlseisqsrfnankfyhpdmnhsgtinvrhsyflTQDPHSFDAPFFGIKPL 95   Chaetomium gl...
XP_002385245    7 IAIVGRSCRFPGgSSTTAQLWKLLLEPqdlsseppsgrfnadafyhndprrpgttnavksyflDEPIDRFDAPFFNISRT 86   Aspergillus f...
BAE61265        7 VAIIGTGCRFPGgSNSPHELWELLVNPrdvarkvppdrfniaafhhpqmghhgttaawesyflDENIQRFDASFFNISPT 86   Aspergillus o...
BAD38874       58 VAIIGAGLRLPGgIDTLDAYWTALAEGrdlvrpmpehrkgp--------fadawrglpqrggfLDEVLDFDAGFFGISPR 129  Streptomyces ...
YP_120537       4 IAVVGIGCRYAGgIDSPESFWDFLIDKrdgvvdippqrwdyrrfydpdkrtpgrmytkraafmTGDPWEFDPDFFGISPR 83   Nocardia farc...
YP_119236       4 IAIVGIGCRFGGgIDSPETFWDFVVDKrdavveipadrwdyrryydpdkrtpgrsytkrgafmTGDPWEFDPDFFGISPR 83   Nocardia farc...
YP_632255      12 IAIIGIGCRFPGgAKSPRHLWELLTQGrcaivevpkerwdhrryydpdpdkpgktyvraggflQEAIDTFDAAFFSISPR 91   Myxococcus xa...
YP_003950773    9 IAIIGIGCRFPGgASSPRHLWDLLAQGrsaivevpkdrwdhrryydpdpdkpgktyvrsggflQEPIDLFDAAFFSISPR 88   Stigmatella a...
ZP_01460630    24 IAIIGIGCRFPGgASSPRHLWDLLAQGrsaivevpkdrwdhrryydpdpdkpgktyvrsggflQEPIDLFDAAFFSISPR 103  Stigmatella a...
3HHD_A         73 QAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETsealsrdpetlvgysmvgc--qrammanrlsfff 150  human
XP_001221381   96 EADAVDPQQRLLLETTYNALEDAGIPLPKIKGSRTGVFIGLMTEDYsniigrdlqnvpqyfasgt--arsiisnrvsyvf 173  Chaetomium gl...
XP_002385245   87 EAESIDPQQRLLLETVYEGLEAAGCRLEDLSGSSTGVFCGVMCDDYrsmvfrdldtlpqyaatgt--sqaivanrisyff 164  Aspergillus f...
BAE61265       87 EAAAMDPQQRLLLETVYESLDRAGLRLEELQGTQTGVFCGLMRHDYhrlltadmetnppyalagt--agsvlanrvsyff 164  Aspergillus o...
BAD38874      130 EARHLDPQHRLLLEVAWEALEHAAVPAGTLAEARAGLYLGVMWQDYrewcegepdaywatgng-----hnfaagrvayal 204  Streptomyces ...
YP_120537      84 EAASMDPQQRLILEVAWEALDDAGIAGRVAGRPV-GVYVGAFTLDQlavsvagdalphvdmhtavgasytmlsnriayal 162  Nocardia farc...
YP_119236      84 EATVLDPQQRLLLEVTWEALDDAGIAPRTAGRQV-GVYVGGFVVDQsvvgvvgpalahvdmhtaasasytmlsnriayal 162  Nocardia farc...
YP_632255      92 EAATLDPQQRLLAEVAWESLEDAGLPADKLAGSPTGVYVGGFMLDSmlthmgpmnreligphtavgstmtvlsnrlsymf 171  Myxococcus xa...
YP_003950773   89 EAATLDPQQRLLAEVAWESLEDAGLPPDGLAGTQTGVYIGGFMLDSmlthlgpvnrlligahtavgstmtvlsnrlsfmf 168  Stigmatella a...
ZP_01460630   104 EAATLDPQQRLLAEVAWESLEDAGLPPDGLAGTQTGVYIGGFMLDSmlthlgpvnrlligahtavgstmtvlsnrlsfmf 183  Stigmatella a...
3HHD_A        151 dfrgpSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGV 230  human
XP_001221381  174 dlrgpSMTIDTACSSSLVALHLAVQSLRSGESDCALVGGSNLLLSPEQYIAGTKLKLFSPSGRSRMWDKDADGYGRGEGV 253  Chaetomium gl...
XP_002385245  165 nlrgpSITVDTACSSSLVAVHLAARALADGDCHLAVAAGTNLILAPNVFLSESSLNMLSPTGHSRMWDANADGYARGEGV 244  Aspergillus f...
BAE61265      165 dwhgpSITIDTACSSSLVAVHLACESLRKGECSLAIVGGSNLLLSPDPYIWESKMQLLSPTNRCHMWDASADGFACGEGV 244  Aspergillus o...
BAD38874      205 gltgpTMTVDTACSSSLVAVHLAVQALRRGECELAFAAGANLIMSPQTMRLVQETRSLSPDGLCKTFDSRANGFTRGEGV 284  Streptomyces ...
YP_120537     163 nlvgpAVTVDTACSSSLVALHLACQALDNGDCEVAMAGGVTMLLQPEPFVSMCKGGFLAADGRSKPFDAAADGYGRGEGS 242  Nocardia farc...
YP_119236     163 dlvgpALTVDTACSSSLVAFHLACQALDNGDCEVALAGGVNVMLQPETFVMMCKGGFLAADGRCKSFDAAGDGYGRGEGG 242  Nocardia farc...
YP_632255     172 dfqgpSISLDTACSSSMVAVHLACQDLRSGTTSLALAGGVNVMFRPEIFVAMSKGKFLSADGYSKSFDTRADGYGRGEGA 251  Myxococcus xa...
YP_003950773  169 dfrgpSISLDTACSSSLVAVHLACQDLWSGTTTLGLAGGVNVMFRPETFVAMSKGKFLSTDGYSKSFDSRADGYGRGEGA 248  Stigmatella a...
ZP_01460630   184 dfrgpSISLDTACSSSLVAVHLACQDLWSGTTTLGLAGGVNVMFRPETFVAMSKGKFLSTDGYSKSFDSRADGYGRGEGA 263  Stigmatella a...
3HHD_A        231 VAVLLTKKSLARR----VYATILNAGTNTDGFKEqGVTFPSGDIQeqlirslyqsagvapesfeyieahg---------- 296  human
XP_001221381  254 AVLVLKRVSQALSdcdsIECLVRETGVNQDGKTK-GITMPSAEAQidlikttylrsgldlsrpserpqyfeahgt--gtp 330  Chaetomium gl...
XP_002385245  245 AAVVMKRLSDAIRdgdhIECVVRATNVNQDGRTP-GITMPSPEAQkdlimktysdagldpqnrpedrcqyfeahgt-gtr 322  Aspergillus f...
BAE61265      245 ASVVLKRLTDALAdgdhIECVIRATGVNSDGRSP-GLTMPNSNAQsalimdtyaraglhpkqnphdrcqffeahgtgtka 323  Aspergillus o...
BAD38874      285 GAVLLKRLDHALRdgdrVLGVIRGTSVNQDGRSS-GFTAPNVLAQvslieaaladagleadavgyaethgt--------- 354  Streptomyces ...
YP_120537     243 GMVVLKKLADAERdgdrIYAVIKATGSNQDGRTT-AITVPNADLQealaksvteragiaphqvtyveahgt--------- 312  Nocardia farc...
YP_119236     243 GIVVLKKLDDAVRdgdrIYAVVKATGANQDGRTT-AITVPNADSQealaravceraglaperisyveahgt--------- 312  Nocardia farc...
YP_632255     252 GIVVLKRLSDAVRdqdrVYAVIRGTGVNQDGHSE-SMTAPSSRAQealirrvcasaaldpteihafeahgt--------- 321  Myxococcus xa...
YP_003950773  249 GIVVLKRLADAVRdndrIYALIRGTGVNQDGHSE-SMTAPSARAQealirhvcanasvsptelhafeahgt--------- 318  Stigmatella a...
ZP_01460630   264 GIVVLKRLADAVRdndrIYALIRGTGVNQDGHSE-SMTAPSARAQealirhvcanasvsptelhafeahgt--------- 333  Stigmatella a...
3HHD_A        297 --tgtkvgdpqelngitralcatrqepLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGl--WAPNLHFHSPNPEIPALL 372  human
XP_001221381  331 agdpieaeainkaifgqanhqhsgsqpLYVGSIKTVLGHAESAAGVAGVMKASLALQHG---VLPPNMLLNELSQTVKPF 407  Chaetomium gl...
XP_002385245  323 agdpqearaihgaffgpsatasndssaLLVGSVKTIIGHTEGAAGLAGLLKASLCIENA---TISPNMHFENLNPDIAPY 399  Aspergillus f...
BAE61265      324 gdpqeaaaiqdalfgcnmeenqpnnetVYVGSIKTIIGHTAGAAGLAGVIRASLALQNG---VVPPNLHFNRVSDTVAPH 400  Aspergillus o...
BAD38874      355 --gtplgdpiemdalatalgrrnggapLPVGALKTNFGHLEGTAGVAGLIKAMLCVSRR---QVPPVVHFRHLNPRIDLS 429  Streptomyces ...
YP_120537     313 -gtpvgdplelraigraygqvpgrtrpLGVGSVKGQLGHTEAASGIASVIKSALAIAHR---TIAPQGWLNQPNPQIPFD 388  Nocardia farc...
YP_119236     313 -gtpvgdpielralgrvygavegrettLGVGSLKATLGHTEAASGIAGVIKSALALTHR---TLPPQGWLNELNPDIPFA 388  Nocardia farc...
YP_632255     322 --gtavgdpaelgglgavskredgqgpW-VGSLKANIGHLEAAAGVAGLIKASLCLQHRqlpPQANLRNLNPAIPFDTLG 398  Myxococcus xa...
YP_003950773  319 --gtavgdpaemgglgavskrpgaqgpW-VGSLKANIGHLEAAAGVAGLIKASLCLQHRq-lPPQANLQKLNPAIPFGEL 394  Stigmatella a...
ZP_01460630   334 --gtavgdpaemgglgavskrpgaqgpW-VGSLKANIGHLEAAAGVAGLIKASLCLQHRq-lPPQANLQKLNPAIPFGEL 409  Stigmatella a...
3HHD_A        373 DGRLQVVDQPL------PVRGGNVGINSFGFGGSNVHIILRP 408  human
XP_001221381  408 YSNLQILQEAQswppvsS-----------GPRRSEITL---V 435  Chaetomium globosum CBS 148.51
XP_002385245  400 AGSLRVPTEVLpwptlsPGTPRRASVNSFGFGGTNAHIILES 441  Aspergillus flavus NRRL3357
BAE61265      401 TTHLEVPTRAVrwpelpSGVPRRVSVNSFGFGGTNAHAILES 442  Aspergillus oryzae RIB40
BAD38874      430 GTGMTVPDTLGew---sPLSGDCASVSSFGMSGTNAHAIVGP 468  Streptomyces carzinostaticus
YP_120537     389 ELGIRLQLEAEpv--gpEVERMTIAVNGFGYGGTNAHAILQE 428  Nocardia farcinica IFM 10152
YP_119236     389 DLNLHVQLEAQpy--esETVPMTIAVNGFGYGGTNAHAILQE 428  Nocardia farcinica IFM 10152
YP_632255     399 IRIPRALETLAp----rKDEPLRMGVNSFGYGGTNAHCVIEQ 436  Myxococcus xanthus DK 1622
YP_003950773  395 GLRVPQRIEALep---rNGEALKMGVNSFGYGGTNAHCLLEQ 433  Stigmatella aurantiaca DW4/3-1
ZP_01460630   410 GLRVPQRIEALep---rNGEALKMGVNSFGYGGTNAHCLLEQ 448  Stigmatella aurantiaca DW4/3-1
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