3KFV


Conserved Protein Domain Family
GuKc

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smart00072: GuKc 
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Guanylate kinase homologues.
Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities; instead at least some possess protein-binding functions.
Statistics
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PSSM-Id: 214504
View PSSM: smart00072
Aligned: 31 rows
Threshold Bit Score: 123.557
Threshold Setting Gi: 116410
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KFV_A        115 TQRSREDLSALT-RQGRYpPYERVVLREASFKRPVVILGpvADIAXQKlTAEXPDQFEIAETV--SRTDS--P--SKIIK 187
gi 12230847   577 tQRSREDLSALT-RQGhypPYERVVLREASFKRPVVILGpvADIAMQKlTAEMPDQFGIADSVl---rTDs---pSKIIK 649
gi 74844448   602 reNWDDVVFSDS-ISKFP-AYERVVLRHPGFVRPVVLFGpvSDLARERlAKDFPDKFSTPLQDddKSAAT--SgkCRIVR 677
gi 74962251   479 EGVGCLKLRDRL-LESDRiTLACPVPYTSRTPKEGEFNG--VHYHFVS-KQKFHEDAKSGKFVefGEYQK--F--WYGTA 550
gi 939885     383 QGVGRRSLKNKL-IMWDPdRYGTTVPYTSRRPKDSEREG--QGYSFVS-RGEMEADVRAGRYLehGEYEG--N--LYGTR 454
gi 119572046  419 LGARLHELKQKV-VAENPqHFGVAVPHTTRPRKSHEKEG--VEYHFVS-KQAFEADLHHNKFLehGEYKE--N--LYGTS 490
gi 55959703   693 QKVDCTALRPVL-ILG---PLLDVVKEMLVNEAPGKFCRcpLEVMKAS-QQAIERGVKDCLFVdyKRRSG--H--FDVTT 763
gi 292938     602 lRKSREDLSAQP-VQTKFpAYERVVLREAGFLRPVTIFGpiADVAREKlAREEPDIYQIAKSEprDAGTDqrS--SGYIR 678
gi 16131920    12 SGSGKDSLLAEL-RLREQtQLLVAHRYITRDASAGSEN----HIAL-S-EQEFFTRAGQNLLAlsWHANG--L--YYGVG 80
gi 498013     699 lRKSREDLTAVVsVSTKFpAYERVLLREAGFKRPVVLFGpiADIAMEKlANELPDWFQTAKTEpkDAGSEk-S--TGVVR 775
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KFV_A        188 LDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFF-IPESRPALKALR----------Q---WLAPA-----SRRST 248
gi 12230847   650 LDTVRVIAEKNKHALLDVTPSAVERLNYVQYYPIVVFCa-PESRAALKALR----------Q---WLAPA-----SRRSA 710
gi 74844448   678 LSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLk-TDSKHVIKQLR----------H---GLPKA-----AHKSS 738
gi 74962251   551 KKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIaAPSLYILRRQREve-----------gTFGVK-----DDELK 614
gi 939885     455 IDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIeAPDFETLRAMNRaalesgistkQ---LTEAD-----LRRTV 526
gi 119572046  491 LEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVkPAIQEKRKTPPM----------S---PACEDtaapfDEQQQ 557
gi 55959703   764 VASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIhYKSAKHIKEQRD----------PiylRDKVT-----QRHSK 828
gi 292938     679 LHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLn-PDSKQGVKTMR----------M---RLCPE-----SRKSA 739
gi 16131920    81 VE-IDLWLHAGFDVLVNGSRAHLPQARARYQSALLPVClQVSPEILRQRLE----------N---RGREN-----ASEIN 141
gi 498013     776 LNTVRQVIEQDKHALLDVTPKAVDLLNYTQWFSIVISF-TPDSRQGVNTMR----------Q---RLDPT-----SNNSS 836
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
3KFV_A        249 RRLyA-Q-AQKLRK-HsS-HLFTATIPLN-GTSD-TWyQELKAIIREQQ 291
gi 12230847   711 RRL-Y-AqAQKLRK-H-SeHLFTATIPLR-GTSD-TWyQELKAVVREQQ 753
gi 74844448   739 KKL-L-EqCQKLER-V-WsHIFSTQIALS-DEES-WY-RKLRDSIDLQQ 780
gi 74962251   615 AIL-T-Q-SKSIEQ-K-YgHLFDGIIVNI-DFEK-SF-RELKQILMKVN 655
gi 939885     527 EES-S-R-IQRGYG-H-Y---FDLCLVNS-NLER-TF-RELQTAMEKLR 564
gi 119572046  558 EMA-A-S-AAFIDR-H-YgHLVDAVLVKE-DLQG-AY-SQLKVVLEKLs 598
gi 55959703   829 EQF-E-A-AQKLEQ-E-YsRYFTGVIQGG-ALSS-IC-TQILAMVNQEQ 869
gi 292938     740 RKL-Y-ErSHKLAK-N-NhHLFTTTINLN-SMNDgWY-GALKEAVQQQQ 782
gi 16131920   142 ARL-ArA-ARYTPQ-D-C-H----TLNNDgSLRQ-SV-DTLLTLIHQKE 179
gi 498013     837 RKL-FdH-ANKLKKtC-A-HLFTATINLN-SAND-SWfGSLKDTIQHQQ 879
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