2NBB,6ES4


Conserved Protein Domain Family
hnRNP_Q_AcD
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pfam18360: hnRNP_Q_AcD 
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Heterogeneous nuclear ribonucleoprotein Q acidic domain
This is an acidic sequence segment domain found in the splicing factor SYNCRIP (hnRNP Q) which is involved in viral replication, neural morphogenesis, modulation of circadian oscillation and the regulation of the cytidine deaminase APOBEC1. This domain is a self-folding globular domain with an all alpha-helix architecture with negatively charged surface areas. Additionally it contains a large hydrophobic cavity and a positively charged surface area as potential epitopes for inter-molecular interactions.
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Statistics
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PSSM-Id: 465724
Aligned: 16 rows
Threshold Bit Score: 73.8249
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2NBB_A         12 GLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYR 81  
XP_005706889  283 HLPSRVADSLQLVFASGVCHPSKFDDLAMEVLVSLEENDAVQALKEFANVDPSTVRNPSAFWMGIARRYQ 352 
KZS09141       28 GLDRRVAEKLEEIYKTGKLVHSELDDRALDALKEFPADGAQSVLLQFLDSNLEHVSNKSAFLCGIMKTYR 97  
KRX97115       84 GLNEKVAEAMTKLICNGVVMLEDVDDRILEIISSMRVEQALCVIQKFKEVDLLGVSCTAAYLGSLMKTFR 153 
KJH52393       50 QMKQSVAEAMMKLFDSGFMAAEDVDERAVEMMNSFPEDQARYVVEQLKESRLFGVQNKAQYLMSLMRNFR 119 
VDD91868       67 NLKADVAVALIQLYEATDLTPEDVDDRVVEMLRSFPVDHAVFIVNQLKEANLIGVINKPQFLMSIMRNFR 136 
VDN50851       85 NLKPKVAAVLVELFGATDVTAADFDDRAIELLRSFNEEHALFVIKEIKESNLIGVQNKAQYLMSIMRNFR 154 
EEC69560       98 SLPSAVKELLLRILRLRIGTRYDIDIHCIRSLNELPEKAAVAVLNQFLISGADK-HNKGDYFASLIAKYQ 166 
XP_005833043  201 GLIPSVQQKLDALFASGKCARSDIDSRCMEQLRALPEQYALEVVQKFNEADLSSIHSRSGFFMGIIKRFR 270 
XP_005820116  681 ELPAAVQHELHDAVRGGRFRESRINKVSLSFFKSLSPADASRVCKMIKEVEPRKYSNVNFCINDIMSKMR 750
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