Conserved Protein Domain Family
Cadherin_tail

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pfam15974: Cadherin_tail 
Cadherin C-terminal cytoplasmic tail, catenin-binding region
Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.
Statistics
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PSSM-Id: 318236
View PSSM: pfam15974
Aligned: 7 rows
Threshold Bit Score: 131.613
Threshold Setting Gi: 1041119857
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878430   798 RQPNPDWRYSASLR-AG--MHSsvhle---------------eagiLRAGPGGP--DQQWPTVSS--------ATPEPEA 849
gi 512828808  834 KHPHPDWRYSASLR-AA--MQGavhme---------------gaavLRGGAGGL--EQQWPTVSS--------ATPEPEG 885
gi 972977357  707 KPPNTDWRFSQGQR-PG--PSG------------------------APQRPE-E--AGPWPNPPTeaeqlqalMAAANEV 756
gi 675315168  814 KHPNPDWRYSASLR-AG--MQRgelynltmiyaysvlciwrrqesyVEDQEGLIssGQQSP------------VLLQVRA 878
gi 1041119857 168 KPPNNDWRFTQGQR-PG--PSG------------------------ATGGPEVAmgTGPWPQPPTeaeqlqalMAAANEV 220
gi 119514175  810 KAPNADWRYSASLRaAG--VQSsvhme---------------easvMQGAQGML--VQNWPTVSS--------AADGEGG 862
gi 119514204  791 KMPSADWRYSASLR-AGgvMQSsvhme---------------essvMQGAQGVL--VQNWPTASS---------AADAEG 843
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878430   850 GEVSPPVGA---GvnSNSWTFKYGPGN----PKQSG----PGEl-PDKFIIPGSPAIISIRQEPT-------------NS 904
gi 512828808  886 GEVSPPVGA---GvnCNSWTFKYGPGN----PKQPVpqipPDF--PENFIIPGSPAIISIRQDQP-------------SA 943
gi 972977357  757 SEATNTLGAstlGpgTMGLSTRYSPQF----TLQHV----PDY--RQNIYIPGSTATLTGNNPQAqtqaq---vqvqaLP 823
gi 675315168  879 GEVSPPVGA---GvnSNSWTFKFGPGN----PKQGG----PGEl-PDKFIIPGSPAIISIRQEPP-------------NS 933
gi 1041119857 221 SEATATLGP---G--TMGLSTRYSPQF----TLQHV----PDY--RQNVYIPGSTATLTSNP--QqqqamaqqatqqaLP 283
gi 119514175  863 GELSPPVGA---GvnSNSWNFRYGAAQayypPQPLK----PGEipPEAFIIPGSPAIISIRHDAG--------------P 921
gi 119514204  844 GEVSPPMGA---GvdSNSWHFRYGPGGpgapPQHLK----PGEvpPEAFIIPGSPAIISIRQNQG--------------G 902
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 13878430   905 QIDksdfiTF----------GKKEET-KKkK----KKKKGNK 931
gi 512828808  944 QNQkn-fiTF----------GKKEETkKK-K----KKKKGNK 969
gi 972977357  824 QPQpa-avEA----------PKPA------QtpanKKKSGKK 848
gi 675315168  934 QIDksdfiTFgkkeetkkkkKKKKGN-KTqE----KKEKGNs 970
gi 1041119857 284 PPQ-----AS----------AQAEPP-KAaQtpasKKKSTKK 309
gi 119514175  922 VDDkgefiSF----------GKKDEA-KKkK----KKKKDKK 948
gi 119514204  903 EDDksdfiTF----------GKKEEA-KKkK----KKKKEKK 929
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