3WSZ


Conserved Protein Domain Family
Sortilin_C

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pfam15901: Sortilin_C 
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Sortilin, neurotensin receptor 3, C-terminal
Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarisation to modulate cell survival and synaptic plasticity.
Statistics
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PSSM-Id: 339545
View PSSM: pfam15901
Aligned: 341 rows
Threshold Bit Score: 97.7386
Threshold Setting Gi: 332321909
Created: 13-Apr-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WSZ_A        504 TEPGEKSTVFTI--FGSNKENvh--------swLIL-QVNATDALGVPCte-------nDYKLWSPSDer--gNECLLGH 563  human
EIE77783      470 TDPESTSRKFLL--IAGSVRSsdq-------knVQIfQLDFSNIFSRQCqldknndansDFEKWYARDlt-egADCLMGH 539  Rhizopus dele...
EPB82016      521 TDPESSSRNFLL--VGSSVRSssd-------akVQAiQLDFANVFSRQCelnekdesrsDYERFVARDvt-sgPDCLMGH 590  Mucor circine...
XP_011275932  505 STPDSTTFKFLL--GGFTSng-----------qYKAyGLNFNNLYDRKCgd-------sDFDDWFVKDeqsnqPMCFMGH 564  Wickerhamomyc...
XP_002492879  485 TTPDATSLSFLV--VGTNNDd-----------kYIAqALNFRGVYDTVCse-------sEFEDWYP-IdskgkKICIMGH 543  Komagataella ...
XP_011121848  511 TTPDSTSTKFTMvaVGPADDDnk---------sRYIfFFDFSDVRGRTCkedk--sgkgDFEKWYARVdekgdPDCLLGH 579  Arthrobotrys ...
XP_011111111  497 TTPDSTSTKFTMiaVGPPDDDnk---------rYYIiQLDFSDVRSRTCkedk--sgkgDFEKWYARLdekgdPDCLLGH 565  Dactylellina ...
XP_007871956  511 VIPNSKTGKFLL--IATEFNEndi------dhsINAiSIDIGEAFTKQCildkndleksDLEKWYSHTen--eSNCSMGR 580  Pneumocystis ...
CCG81697      512 TVPDSTTEKFTL--VASRGKGens------danAHVfSIDFSGMRTKKCilktdnveksDFEKWYARYntdgsPACLMGH 583  Taphrina defo...
ESA06247      432 TDP--TSKNFLL--LGSAVPNhdtpgdgssnyrHFIfKLDFSKLFDRDCnr-------dDFDDWVAKRse-sgSDCFMGK 499  Rhizophagus i...
3WSZ_A        564 KTVFKRRTpHATCFNGEDFDrpvV-VSNCSCTREDYECDFGFKMSEDlsleVCv----------PDPEFSgksysppVPC 632  human
EIE77783      540 EQIFYRRKaDRDCYVGREFQdpeVeVKNCPCTRADYECDYNFARDkn---gDCvrig---pdriFANQ-----------C 602  Rhizopus dele...
EPB82016      591 EQIFYRRKaDRDCYVGRDYQdpvVeLKDCPCTRADYECDYNFMRNpd---gSCtrvg---pdriSEDV-----------C 653  Mucor circine...
XP_011275932  565 KQRFKRRIsDANCFVGDEYKepvAvEDSCPCTEADYVCSYNFKRDASg---KCvpav---tsltPDAVQK-------KEC 631  Wickerhamomyc...
XP_002492879  544 KQKFSRRKpSAACSVSKLYLeavSvQEDCPCTEQDFECAQGFSRNsq---gKCladnieaelalQRKL-----------C 609  Komagataella ...
XP_011121848  580 KQFFWRRKkDVDCFVNNLYKeqePeREVCKCTTEDYECDINFVREKGqpgdKCvpkk---lkydDKGK-----------C 645  Arthrobotrys ...
XP_011111111  566 KQYFWRRKkDADCFVNNLYKeqePeRDTCKCTSEDFECDINFVRENGnpgdKCipkn---akfdDKGK-----------C 631  Dactylellina ...
XP_007871956  581 KQYFWRRKiGRKCFIKENYSelqViEENCPCSNNDYECDYNFMEYDN----KCleqv---pqeiPPDA-----------C 642  Pneumocystis ...
CCG81697      584 KQFFWRRKaDRDCFVGDKYHepeAkEENCPCQEDDFECDYNFVRTDG----KCvpsa---rnplAAEK-----------C 645  Taphrina defo...
ESA06247      500 KTTYHRRKvEARCFVVSsqq-psPdIENCACTEKDFECDFNYILDEDk--eKCipll---periPEGE-----------C 562  Rhizophagus i...
3WSZ_A        633 p--vGStyr----rtRGYRKISGDTC----SGGdve--arlEGELVPC 668  human
EIE77783      603 tskdDYya-----asSGYRIISGNTCippsRGRl------dYPVERKC 639  Rhizopus delemar RA 99-880
EPB82016      654 rskdDFyp-----gsSGYRLIPGNTCvlgnGTPl------dEPVDRKC 690  Mucor circinelloides f. circinelloides 1006PhL
XP_011275932  632 -----VdnaqtyfepSAYTIRPGSVC------SvlngvnlnVKVEKTC 668  Wickerhamomyces ciferrii
XP_002492879  610 vngaTSye-----vpSGYQLILGNTC-----QGssd---lqTPLQKRC 644  Komagataella pastoris GS115
XP_011121848  646 skpsDTfk-----gpSGYRLIPGDSCd--kNGGed----leKETDRTC 682  Arthrobotrys oligospora ATCC 24927
XP_011111111  632 skpsDKfm-----gsSGYRLIPGDNCe--kSGGed----leKDTERAC 668  Dactylellina haptotyla CBS 200.50
XP_007871956  643 kkpdDVfw-----apSGYRKIPGNICd--sKRGvi----kdKKIEVSC 679  Pneumocystis murina B123
CCG81697      646 kagqKTfk-----gpSGYRLIPGNTCd--kSRGls----ldDEVERSC 682  Taphrina deformans PYCC 5710
ESA06247      563 kd-kDTye-----gsSGYRKIPENECdpekPNSvr----ldEPKTKKC 600  Rhizophagus irregularis DAOM 181602
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