Conserved Protein Domain Family
TEX15
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pfam15326: TEX15 
Testis expressed sequence 15
TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.
Links
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Statistics
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PSSM-Id: 464647
Aligned: 7 rows
Threshold Bit Score: 405.427
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_023406902 1954 RTRrEKGGKVKATSDSQPDSIAPSEITCNFKPGVTEINHKPIPHAYPEVFEVT-ALQKKPTSYLNELKEKHGTANHAGFL 2032
XP_003269593 1913 NKR-EKKGEIKASNDSQSDLTLHSEIAYISKPGILGVNHMPILPAHSETCKVT-TLLKKPASYMSEFKEKHCSANHTALI 1990
XP_023372774 1917 NKR-EQKGKIKISSDSQSDSTLHSETTNISKPDILGIHSMPVLHAPSETSKVT-T-CQKSTSYINELNEKHRSAKHTALI 1993
XP_027818378 1949 NKRkEEEG--RVSQDSQYDSSLHSEVACDSKPGITGRNHMPHLRGQSEPPKVSpPPPKKSTSYMNEFKEKHCSSNNLAPT 2026
XP_008250503 1930 KKRkEKEGEIRSSNHPQSD--------YISQPSILEINHMPVSLAHSETSEVI-TLPTKPTLYTSDLIENHYSVGHMALL 2000
EHB18349     1522 NKR-KRKGKRKVSNDCQSG--------YISKPGILEIDHRPILHAHSETSEVT---IQKPTSYENELKENHCSVTQTALV 1589
F8VPN2       1574 KER-KEAGQIKVNNNSHSD--------CLSKPAIVETNHRPVLHGNPKVATLQ-----------KELKE-HRSPNYTSHV 1632 house mouse

XP_023406902 2033 AQLSQILQRADEASSLQILQEETKVCQNILPSFVEAFERNQECSLEQVLISRDLLVQQNLWNNCKNKLKPCALDSLVELQ 2112
XP_003269593 1991 ANLSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQ 2070
XP_023372774 1994 TKVSEILQRADEASSLQALQEETKVCQKCFPSFVEAFERKQKCSFEQIVISRESLVEKNMWNNCKHKLKPSAVDTFVELQ 2073
XP_027818378 2027 VKLTQILRRADETSSVQILQEESEVCQNILPLFVEAFERKQKCSFKQILISRDLLVEENLWSNCRHRLKPCAVDSLVELQ 2106
XP_008250503 2001 VELSQILQRADEATSLQLLQEESMVCQNMLPLFVQAFEKKQECSLEQILITREVLVEQNLWDNCKHKLKPCAVDTLVELQ 2080
EHB18349     1590 TELSQILQRADEASSLEILEKETKTCQNILPLFVEAFERKQECSLEQILISRELLVEQNLWKNCKYKLKPCAIDTLVELQ 1669
F8VPN2       1633 TELSQILQRADEAASLQILEEETKLCQNILPLFVQAFERQQECSIDQILISRKLLVEQNLWNNCRLKLKPCAVDTWVELQ 1712 house mouse

XP_023406902 2113 MMMETIQFIENKKRLLGDEPTFRSLLWYDETLYGELLGGPRGYQQQSNFYPAFQARLKYNAYCELQKYHDQLIEVL 2188
XP_003269593 2071 MMMETIQFIENKKRHLEGEPTFRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELL 2146
XP_023372774 2074 MMMETIQFIENKKRLLGGEPTFRSLLWYDETLYGELLVGPHGYQQQSNFYPAFQGRLKYNAFYELQTYHGQLIELF 2149
XP_027818378 2107 MMMETIQFIENKKRLLGGEPTFRSLLWYDETLYSELLGRPRGFQQQSNFYPAFQGRLKYDAFSELQSYHGQLIELF 2182
XP_008250503 2081 MIMETIQFIENKRRLLEGEVTFRSLLWYDDTLYGELLGRPRGYQQQSSFYPGFQGRLKYNAFCEMQNYHNQLIELC 2156
EHB18349     1670 MVMETIQFIENKKRLLEGEPTFRSLLWYDETLYSELLGRPHGYQLQSSFYPAFQGRLKYNAFCELQNYHNQLIELF 1745
F8VPN2       1713 MAMETIQFIENKKRFLEGKPTFRSLLWYDESLYSELLRRPRGYQLQSNFYPGFQGRLKYNAFCELQNYHNQLVE-F 1787 house mouse
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