Conserved Protein Domain Family
DUF4407

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pfam14362: DUF4407 
Domain of unknown function (DUF4407)
This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.
Statistics
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PSSM-Id: 316850
View PSSM: pfam14362
Aligned: 81 rows
Threshold Bit Score: 113.098
Threshold Setting Gi: 81376435
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123582750  20 EIIEKYP-T-EHSK-YTGIGATIFFTALFAALSGGYALFFVFSGN-PLgslW-ALLFGVVWGLAIFNLDRYIV------- 87
gi 503452526  34 ELIEVCT-V-DRNR-YKILGSAMLFTWLYATLAWGYFWSTNSDSP-FL---F--VSLGIFMGGFVLSIDRVLV------- 97
gi 503637541  11 dpahvtvfT-DRAR-YTCAALFMALYYVYATAGCTFFLMIATGGG-IF---P-GVLVGLLVAAAVVVYDRFLL------- 76
gi 503209212  17 DILKNCSeA-SYKA-LKKYASSILILLFIWGATGYTFAQRYLSVHtWW---G-CALTALIFMIIVIQIERQVI------- 83
gi 504260364  16 nprsvtthS-DRVL-YRSIGVFIILYFGYATAGGAAFIDASTGYA-HP---WyQWVVGPLVAIGVVAYDRTVVgrvavny 89
gi 503988327  18 gIVRTSS-E-VSSKaVKKYTSAMLIVCILWSFVGFMFTQRYLRGN-IW---G-SVAGSALMVVIIVQIERQII------- 83
gi 506233445  18 YLLKNSS-E-ASAKsVKKYLSAILIISILWAFIGYSFAKRYLKTD-DV---V-SIIVALIMVIVVIQIERQII------- 83
gi 495781201  18 rILQGCS-EvAHRA-VKRYTAALIIICTLWGFIGYTFVGKYLKGE-WH---M-SLFGGALFVLIILQVERQII------- 83
gi 763166726  18 QILGGCTeA-SRKQ-LKKYSSAILILVILWSFIGYSFAERYVGAP-IW---G-RILTAFIFVVIIVQIERQII------- 83
gi 504507480  16 nprsvtThS-DRVL-YRSIGVFILLYAVYATLGGAAFIDAGSGYR-HPw--F-QWLVGPLVAIGVVAYDRAVV------- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123582750  88 ----SSIkkt-----------skGLRQFYQASPRLVFAVLIAIVIARPLELKIFDKEI-RARLEEKYLAAERAQIAGV-Q 150
gi 503452526  98 ----SSIn--------------kKRTNIVAIALRVVMALCIGAFLAQPIILFIFSSDI-DREVPILLDKKLAEKKIEV-E 157
gi 503637541  77 ----SQVsvdfsdlh-eedarphGRPRIGSYAIRVVITLLIAVIVTDPLVLKMFDSEI-TAELGRRHTDRTATLNAVV-E 149
gi 503209212  84 ----LTVg-----------------kNKWIVRFRTLLAILMALIGSTILDQIIFKNDV-EKVLVDIRADKINEISGK--- 138
gi 504260364  90 erldSADprh-----------llRPPTPGLYLGRVGLALLFAVVVTEPLMLARYRGEI-DARLAEVHSGQISALDANGpA 157
gi 503988327  84 ----LSLa-----------------RNRWLYISRGILAALMAILGTIIIDQIIFKEDI-ELEKITFIQKR-------V-D 133
gi 506233445  84 ----LNIsq-----------------sIWPKLFRGLIAIVMAIIGSVIIDQIVFKEDV-EKI-------KIAEIQSQV-D 133
gi 495781201  84 ----LSDpgg-----------kaK------YWVRGSIAFIMAIIGSIIIDQYIFREDIaHKELFE--------LNAQV-D 133
gi 763166726  84 ----LTV-----------------GRSKWLSWFRVAIAFIMAILGSSILDQIIFKDDI-QKKMIQIVDRQVNEQ------ 135
gi 504507480  83 ----GRVpisfdqldstdpehllRRPHLGLYLGRIALALLFALLVTEPLMLARYRGEI-DARLAETHSAQLGRLDAGG-A 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123582750 151 DA-FMAKYGMEAGQLQRFQGEYDALSRDVDRLREELKLEVFGRS----------SST-TS----GVPG--YGT---YAKN 209
gi 503452526 158 QV-YQSRKDELLANKKKLDDELKEKSELAIEKQNDYLKEIDG-------------TG-GS----GKFG--IAG---IAKA 213
gi 503637541 150 QV-RSAQLAALDDEIKNDQNQLEAASTAVGKAFTAVTDEREGR-------------G-AT----GLAG--NGP---VFKL 205
gi 503209212 139 ------RQKTMQLEINKLNMIIDSLDVINSKLNDEVAKRPTIAV----------TNV-TTeknpVVNQ--DGTkttNTKT 199
gi 504260364 158 AG-FTTALAALREDTAREDAEVRALTGRAEVKRDDARLLYRQALad------saGRG-VT----RSPGcpPGG---YCHH 222
gi 503988327 134 QG-LPPKTQELNTQIASIDTAILKKEADRSQLIDEVTKTPYIKT----------TST-QS----SPIK--KQT---TIKD 192
gi 506233445 134 EV-VPARTRIIQQQIFDLDSLITVKENALATTQQEFAEKPQ------------------------IRS--VLV---ETRE 183
gi 495781201 134 SL-MPSKQAELKRQINEADSGLAKKERERTTLITELTRNPFIKV----------VTRqDV----PVPI--STV---VVDS 193
gi 763166726 136 ---LSGRLTIIDKKLGELQVEIDSLDKKNLILYEEIS------------------------------------------- 169
gi 504507480 157 VAdYRARLTELRSDTENDDAAVRALADRAAGKRRDARDTYRQALadsagsgvthSPG-CP----R------KG---FCDH 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123582750 210 -------KEDVVQAKQQRLA--------------F-----------LA-------------VQv---------------- 228
gi 503452526 214 -------KQNGYMIAKDNLD--------------K-----------MQ-------------KD----------------- 231
gi 503637541 206 -------LNDNYAKAVARQN--------------E-----------AA-------------ET----------------- 223
gi 503209212 200 -------IVSTQHVANTRIE--------------Q-----------IK--------------S----------------- 216
gi 504260364 223 -----------LVQRSRRLD--------------DqaaaldrqaaaLQ-------------RD----------------- 247
gi 503988327 193 -------SSGKIITTEQVVNstsvsvttvpnpkfT-----------LI-------------AT----------------- 224
gi 506233445 184 -------ELVQEEDSSGQLQ--------------D-----------VK-------------IQ----------------- 201
gi 495781201 194 -------NKRSITRTNQVLK--------------T-----------ANivnsipnpkssmvNS----------------- 224
gi 763166726 170 -------KQPTIKTVSQTIT--------------K-----------IQ-------------FRqgdgsfttrpqttistt 204
gi 504507480 223 lvhrsrsLDEQAAALDRQAA--------------G-----------LQ-------------RD----------------- 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123582750 229 -----------iR-------------------LEEYLDSRKQAEGLNSQMMLSEGEFAR-KASTAGFADRNWALGELAHS 277
gi 503452526 232 ------------S-------------------KTELEKITKELDEINAKVTKSVSDFEKtLDGK-GFLIKKEALQSLFDK 279
gi 503637541 224 ------------L-------------------ATAQSNRSANIERINGDASRQTAENNDsAPPPAGVLDHQDALLAVLRH 272
gi 503209212 217 ------------N-------------------TATIDKCRSRLDELYNQKINVEVTVRKeLEANAGFLEELKAMIVLISS 265
gi 504260364 248 ------------Q-------------------SAARVARAAEQSRLTELIRSEHAANTAvVRGDSGFGARTAAMWHLITA 296
gi 503988327 225 ------------L-------------------DQTISNLRTDKSKKDSALLNIRPELEKqISSKIGFLDELEIMCKLITG 273
gi 506233445 202 ------------LkdykthlisnpigaqipvlDEQIQEHRRMRMAKEDEIVNIRAQTEKeLSEKTGLLDEITILFKIILS 269
gi 495781201 225 ------------I-------------------DQQIKDMGAIKALLEERLIRLRSDVEReAKTNRGFLQELQVMQKILNE 273
gi 763166726 205 pipnpkvketeiN-------------------EQNLEVFRKQKEDYTQKKIKAEASLRQeLKSKQGFLEELNAIIEILRE 265
gi 504507480 248 ------------Q-------------------RPERAARAAEQSRLTALLDAERTANADaVRGDAGFGARTAAMWHLVRA 296
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 123582750 278 G-DdasrSSANAIAFITMLFIALECAPLIVKLLSDAGPSDVDVSETE 323
gi 503452526 280 D-Kt--hGLQNQYYLLMVILTLFELIPIISKLFMSSGAYDTKVALRE 323
gi 503637541 273 N-L----HALLVCVMISLLLIALDLAVLFIKLAGRNSAYEISVAAAs 314
gi 503209212 266 E-A----LAGVFYFLLFTFILALELLVVVSKTKDVTCDYDLVVEHQL 307
gi 504260364 297 DfW----GIGVFYFGIALLLVALDCAAIALKFVSRGNAYeraearaa 339
gi 503988327 274 S-G----VAFFVWIIWFLFLMWLEMLVLISKLTDAKSDYEETIKHQm 315
gi 506233445 270 S-W----IAGVVWGCIFLFFLSIELFVLISKSFESDSDYDRLVRHQk 311
gi 495781201 274 S-G----PALVIWLLWFFLLLGLEVFILVNKIANAETDYDVTIQHHm 315
gi 763166726 266 R-S----VALFFYSILFFFLMFLELFVVASKTKDTKSDYDLVVEHQL 307
gi 504507480 297 D-Fw---GVGVYYLGIALLMVALDCAAIGLKFASRGNAYERNEARag 339
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