Conserved Protein Domain Family
DUF4392

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pfam14336: DUF4392 
Domain of unknown function (DUF4392)
This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.
Statistics
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PSSM-Id: 316825
View PSSM: pfam14336
Aligned: 60 rows
Threshold Bit Score: 164.35
Threshold Setting Gi: 81775935
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8BH86       299 LESTIAVDP-GNRG-IGHLLLKDELLQAALSLS-HA------------R------------S------------VLVTTG 339 house mouse
CCX85866      15 LDDLMNLDP-RGYG-VCRILYKASREYMKEPLT-TK------------CaktlidtvqegdV------------VYIVTG 67  Clostridium sp....
CDD49242      15 LDQLMNLDP-RGYG-VCRILYEGSRAYAGEPVS-MH------------CakalnsmlepgdI------------VYIMTG 67  Firmicutes bact...
CCY91960      15 LDNLANLDP-RGYG-VCRILYKASREYTGMPTT-MN------------AakklcatlkkddI------------VYIMTG 67  Eubacterium sp....
CDB52329      15 LDSLMTLDP-RGYG-VCRILYRAARDYAGEPLSvHA------------A------------Kglvahi-hsgdlVYIITG 67  Clostridium sp....
WP_015711240  15 LDSLMNLDP-RGYG-VCNILYEAAYKRSGGPLT-MK------------AaevllssvgegdT------------VFIITG 67  Treponema azoto...
AFH42035      11 LDQLINSDS-NGRG-VAKKLYPYAFEKAGEPLV-YK------------AarelvensdkgsP------------VLIMTG 63  Fervidicoccus f...
CCY68309      15 LDTLMNLDP-RGYG-VCRILYDGARKFTGEPLS-TNgakglikhikkgK------------K------------VFIFTG 67  Clostridium sp....
WP_015888037  16 IENFMTLDL-TGVGlIGKIYHALQRRQPGPACM-TA------------A------------KlicervrdrggpIVIATG 69  Sinorhizobium f...
ABS66753      16 IDDFMCLDFtGVGL-IGPIRVALARRQPGFIAM-GA------------AeiiaatlttkggP------------ALIATG 69  Xanthobacter au...
Q8BH86       340 FPTHFNHepPEETDGPPGAIALAAFL-Q-AL-GKETAMVV--DqralNLHMRIVEDAIR-Q-GVLKTPipi---ltyQGR 409 house mouse
CCX85866      68 FVLLPFKk--AEMDGIVSAMFLARCLvK-AF-GAKPVIIC--P----EDNMEAVHKLSE-VmGLHLYDsiq----eiLDM 132 Clostridium sp....
CDD49242      68 FILRPHRq--pETDGIVGAILLARALvE-AY-DVKPVIVC--P----EENVVAIKNCSP-LiGMHLYEdip----tlLEM 132 Firmicutes bact...
CCY91960      68 FVLLDHH--HAETDGIVSSMLLARALsL-AF-DVKPVIIC--Q----DENVEAVRNMSR-ViGLHLYDtie----emNAH 132 Eubacterium sp....
CDB52329      68 FVLLPWKq--pETDGMVSSMMLARFLiK-AF-DCTPVLVV--P----EECMEAVRRLAM-VlGFHLYDtve----eaQEY 132 Clostridium sp....
WP_015711240  68 FVLKNYNk--AETDGPVGAAALARSL-IiAK-GAKPVFIV--P----GEAADAVKRLSAiM-GFHLYGsfe----elRAR 132 Treponema azoto...
AFH42035      64 FRTPPLYv--qETDGPLGAASISRAFsI-CL-NAKPIILTeqD----ERSLRIVRAAVEgA-GLKISPled---llrGDQ 131 Fervidicoccus f...
CCY68309      68 FVLLPWNe--AETDGIISSCLFAKFImK-AF-GAKPVMLI--P----SQCEKAIKAISN-V-LDFAVTddi---ddkSEN 132 Clostridium sp....
WP_015888037  70 FPEGAG---VPETDGPVGAALLARAL-F-LGlGIETVILT--D----DDWVEMMVGTCRgA-GLAPLAfptdgvvkpIDF 137 Sinorhizobium f...
ABS66753      70 FPEGGGV---PETDGPVGAALIARALfL-GF-GVESVIVI--D----EDWAEMMAATCR-GaGLAPLPfpadgvirpVPF 137 Xanthobacter au...
Q8BH86       410 SMEDARAFLCKDGDPK-----------S----------PrfDHLVAIERAGRAADGNYYNARKMNIKHLVDPIDDIFLAA 468 house mouse
CCX85866     133 PISMAAIPFTKDPLKAkqqae--eiivE----------AkpAAVVSIEAPGPNEKGVYHNATGLDVTEIEAKTDVLFQIL 200 Clostridium sp....
CDD49242     133 PQSFGVYPFTKKMEEVeeniyrlfsygL----------P--KVLISTEAPGANKKGEYHNAVGINMTELEAKMDGLFDAV 200 Firmicutes bact...
CCY91960     133 PVSMAFIPFTKDKDKAealadeiiskgM----------P--KAVIANEFPGANGVGEYHNAVGKNTTALEAKADILFTKL 200 Eubacterium sp....
CDB52329     133 PFSMCAVPFTKDDREApaqae--allaK----------GvpAAVITNEAPGRNAKGAYHNAVGKCLTELEAKSDVLFNAC 200 Clostridium sp....
WP_015711240 133 PLSAGIMEFTKSADGAkka-----sesLwneanaancvPkfC--IAIEAPGANSRGVYHNAVGLDISPLEAKTDVLFSYL 205 Treponema azoto...
AFH42035     132 DLSASVVGFTHSEEYAeedakrlidevN----------Pr--AVIAVKKAGRNFKGVYHSMSGLNVSKYHAKVEYIVDEA 199 Fervidicoccus f...
CCY68309     133 --TVTYIIFTKERDEApvqakeilshgK----------P--CAAISIEAPGRNKNGFYHNAVGVNTTGVEAKYDVLFKMC 198 Clostridium sp....
WP_015888037 138 IRPVYIRSVPKDEAGCraitdslldvtN----------P--SLVISIERPGRNDRGLYHGLGGRPLDGLVADLDQFFLRA 205 Sinorhizobium f...
ABS66753     138 LRPVYIRTVPKDAEGCrtvadellehtR----------P--QLLIAIERPGANANGLYHGLGGRPLDGMVGDLDYLFRTG 205 Xanthobacter au...
Q8BH86       469 QKIPgISSTGVGDGGNELGMGKVKAAVKKHirn-----------gdvIACDVEADFAVIAGVSNWGGYALACALYILNSC 537 house mouse
CCX85866     201 RNMG-VLNIAIGDLGNEIGMGTIREHIQRYvpyaepgg-cqcgcgggIATSSEADYILTATTSDWGCYGMMAAIAFLKGD 278 Clostridium sp....
CDD49242     201 KNLG-IKTFAVGDLGNEIGMGAIGEHIRKYipyaaege-cqcgcgggLLARTAADYLITATVSDWGVYALISAIAYLKKK 278 Firmicutes bact...
CCY91960     201 QKAG-VLNIAIGDLGNELGMGTVLDHIKKYvpytseksncvcgcnggIASVVAADNIITATVSDWGCYGMIAAIAYLKGD 279 Eubacterium sp....
CDB52329     201 KARG-IYNLSIGDLGNEIGMAAIGDHIRKYvphaddge-cecscgggILVESTADNLITATCSDWGCNAMMAATAYLLGN 278 Clostridium sp....
WP_015711240 206 KKKN-VPTLAIGDLGNECGMGALKAHLEKYipyaapgg-cscgcgggIAAVTAADTVLTTTVSNWGAYGICSALAYLSRN 283 Treponema azoto...
AFH42035     200 RKKG-ILTIGTGDGGNEVGMGAIEDAVRKHvpygdvc---rcpcrggIASSSKVDVLITSSISNWGGYALSGMISKILEK 275 Fervidicoccus f...
CCY68309     199 KDAG-IYNLSIGDLGNEIGMAAIEDHIRKYvpyaemgg-ckagsgfgILADTVADNIITATVSDWGCNALMAATAFLLKK 276 Clostridium sp....
WP_015888037 206 QSKG-VPFVAIGDGGNELGMGVIADELKSFspkakds---ghpgrggVAAATAADHLIVSNVSNWGATGLIAALSALLDK 281 Sinorhizobium f...
ABS66753     206 KAMG-LPFIGIGDGGNELGMGVIAEDLPAFspkaadc---gipgrggVAAATAAGHLLVANISNLGATGLVAALSALLEN 281 Xanthobacter au...
Q8BH86       538 QvherylrratgpsrrageqswiQALPSVAKeEKMLGILVENQVRSgVSGIVGMEVDGLPFHDvHAEMIRKL 609 house mouse
CCX85866     279 V----------------------DIFQDPDLqEYAMKESAKAGMID-MYGWMIPAIDGFGIEI-NRSIVSIM 326 Clostridium sp. CAG:590
CDD49242     279 I----------------------SIMHDKNMeESVLCECARSGMVN-MTGSLLPGIDGFDVTM-NAQIVEMM 326 Firmicutes bacterium CA...
CCY91960     280 I----------------------NIMHDAELeKDVLKAAARSGMVD-MYGWQIPSIDGFDLttnmmmvnmmr 328 Eubacterium sp. CAG:180
CDB52329     279 A----------------------DLFQSEEVqQRAMEEAARAGLLD-MYGRNIPSIDGFGRSI-NLPLVKLM 326 Clostridium sp. CAG:217
WP_015711240 284 K----------------------EVLYSPGLeERALRAASEAGLID-MYGWQIPQVDGMNLAK-NTALITLM 331 Treponema azotonutricium
AFH42035     276 P----------------------NGIHDPEAeELMFSLVAKEGAVDgIKGKAGKSADGLGVEA-HKSVLMLI 324 Fervidicoccus fontis Ka...
CCY68309     277 P----------------------ELFHDTEEqSAAMDAAAAAGMLD-MYGKPRPYIDGIGKNI-NLPLVAMM 324 Clostridium sp. CAG:678
WP_015888037 282 P----------------------SVFHDGELeRRCIEQCVSFGGVDgMFMGPEPAVDGISAIE-WAGLVTTM 330 Sinorhizobium fredii
ABS66753     282 P----------------------VVFHDPELeVRAIEQCVAFGGVDgMFMAPEPAVDGLSAKE-WEGLVRTL 330 Xanthobacter autotrophi...
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