Conserved Protein Domain Family
Shisa

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pfam13908: Shisa 
Wnt and FGF inhibitory regulator
Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.
Statistics
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Aligned: 44 rows
Threshold Bit Score: 82.9046
Threshold Setting Gi: 229282580
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESO03787       16 YEQCPGYTDHHGVWNNGFKCPkw-gYLNDNYCCGGDKNRYCCPPPPSNKTTHVVTSSSGsssggsssgSSGSSSGGNdfL 94  Helobdella rob...
XP_003221598   31 GEYCHGWVGASGRAADGFLCPerfdAADATLCCGSCALRYCCAAAEARLQQDACTNDPR---------APLRPQEPAgtQ 101 green anole
XP_003482906   34 GEYCHGWLDAQGVWRIGFQCPerfdGGDATICCGSCALRYCCSSAEARLDQGGCDNDRQqgagepgraDKDGPDGSA--V 111 pig
XP_003201351   27 GEYCHGWHDAQGVWKDGFQCPerfdTPDAIICCGKCELRYCCSSTEARLDQGTCDNDKQtqet--ntgSKDDKNSGA--V 102 zebrafish
XP_005797960   27 GEYCHGWRDSQGAWKDGFQCPekidGEDSIICCGKCELRYCCASTDARLDQGSCENDKQaevp--gteSKQDKDSRA--V 102 southern platy...
15_pfamImport   1 GEYCHGWQDSQGAWKEGFQCPekidAEDAIICCGKCELRYCCSSVDARLDQGSCQNDREaqep--gaeNRENKDSDA--V 76 
XP_003445306   24 GEYCHGWLDSNGNYHEGFQCPedfdTMDATVCCGSCALRYCCAAADARLDQGICTNDR----------EVDNTEFAA--Q 91  Nile tilapia
XP_003968005   27 GEYCHGWQDSQGAWKEGFQCPekidAEDAIICCGKCELRYCCSSVDARLDQGSCENDQEaqkp--gaeNKDNKESDA--V 102 torafugu
XP_004081318   27 GEYCHGWRDSQGAWKEGFQCPekidAEDSIICCGKCELRYCCASTDARLDQGTCDNDRQaqep--gteTKENKDSRA--V 102 Japanese medaka
XP_006627819   27 GEYCHGGLDGQGAWREGFQCPerfdSVDATICCGKCALRYCCSSTEARLDQGSCENDRRapdt--gadSKDSRDNAA--V 102 spotted gar
ESO03787       95 AgtivgedvileqstVTVPVVVIvtgAGLFIALTIVVATICLCCyfCSC-----------------CNSWKYNVfnGPIK 157 Helobdella rob...
XP_003221598  102 P--------------IYVPFLIV---GSIFIAFIFVGSFVAVYC--CTClrpkqtl---qqpmrfsLRSYQMET--LPMI 157 green anole
XP_003482906  112 P--------------IYVPFLIV---GSVFVAFIIVGSLVAACC--CRClrpkqepp----qsrapggpRLTET--IPMI 166 pig
XP_003201351  103 P--------------IYVPFLIV---GSVFVAFVLVGSVVAVCC--CRClrpkqeptsgggsggasSSARVLET--IPMM 161 zebrafish
XP_005797960  103 P--------------IYVPFLIV---GSVFVAFILVGSVVAVCC--CRClrpkqelssagasgsgsTGGRLLET--IPMM 161 southern platy...
15_pfamImport  77 P--------------IYVPFLIV---GSVFVAFVLVGSGVAVCC--CRClrpkqgee----raagagsgRLLET--IPMM 131
XP_003445306   92 P--------------IYMPFLMV---GSIFIAFIIVGSLVAVYC--CTClrpkqpt---qqpirfsLRSCQGET--IPMI 147 Nile tilapia
XP_003968005  103 P--------------IYVPFLIV---GSVFVAFILVGSGVAVCC--CRClrpkqelssgggtgsgsGSGRLLET--IPMM 161 torafugu
XP_004081318  103 P--------------IYVPFLIV---GSVFVAFILVGSVVAVCC--CRClrpkqelsstgatgggaTGGRLLET--IPMM 161 Japanese medaka
XP_006627819  103 P--------------IYVPFLIV---GSVFVAFVILGSLVAVCC--CRClrpkqepqq---srgpgggaRLMET--IPMI 158 spotted gar
ESO03787      158 DDhmnkDATKISSAIESQAMTSSSTSrprTPAsvhqMtPRILdLtSAV 205 Helobdella robusta
XP_003221598  158 LT----SGSLRTPSRQCSSAASSSCA---AGS----V-HRFSlArPES 193 green anole
XP_003482906  167 PSa---STSRGSSSRQSSTATSSSSSansG--------ARAPpTrSQT 203 pig
XP_003201351  162 ASt---GTSRGSSSRQSSTATSSSSSappAAP----RpAPAPlLrAQA 202 zebrafish
XP_005797960  162 A-----SSSRGSSSRQSSTATSSSSSappAGA----RpGPAPlMrAQA 200 southern platyfish
15_pfamImport 132 ASt---STSRGSSSRQSSTATSSSSl-----------------VrAQA 159
XP_003445306  148 LTt--aPPSLRAPSRQSSTATTSSSSaggGSS----M-RRYSlGgqqq 188 Nile tilapia
XP_003968005  162 ASt---STSRGSSSRQSSTATSSSSSapaAVP----RpSAPAlMrAQA 202 torafugu
XP_004081318  162 A-----NTSRGSSSRQSSTATSSSSSappAAP----RnAPPPlMrAQA 200 Japanese medaka
XP_006627819  159 AGa---GAPRGSSSRQSSTATSSSSSansA--------ARPPmVrAQA 195 spotted gar
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