Conserved Protein Domain Family
Claudin_2

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pfam13903: Claudin_2 
PMP-22/EMP/MP20/Claudin tight junction
Members of this family are claudins, that form tight junctions between cells.
Statistics
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PSSM-Id: 316425
View PSSM: pfam13903
Aligned: 14 rows
Threshold Bit Score: 115.595
Threshold Setting Gi: 241814021
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82173356   18 CLAWIFVMITTGLNEWrlWY---LDVGNTSV--------------------ITSGVAWVGI-WRACfysHVLAKVENCQS 73
gi 123888131  69 ITGIMLTVLGVGTEFW--VE---LAPSKSFYn------------------nQTCLVAHYGL-WKCCtktIEVSDVDPKLE 124
gi 121956500  35 VIALVTVLVAFATPSW--LV---SDYRIT-----------------------GAKLDRLGL-WTHCfrsLPDVNDDYQRR 85
gi 123885913  15 ALGILIYLVAFGSDYW--LLakeIEKCSENQetgd-------------natHSVLLHHEGF-FWRCwfnHAEEENSNTME 78
gi 170050791  16 AVAFLFILIAFVSPYW--LQ---TDGRLE-----------------------NPKFHNLGL-WELClndFQDIHRFYDTR 66
gi 195475702  16 VFSLICFIIAFSTPYW--LV---TDGSLQ-----------------------NPRFTNLGL-WEVCfnnFQDIHRFFDNP 66
gi 241814021  25 YCSTVLLLISFASPYW--LEs--YQEANAEFvrlglwdvc---frnyrhpsYQYDETFNGChWVHSyayQNIRDW----- 92
gi 195126845  40 IFAFAFIAIAFATPSW--LV---SDYRITG-----------------------AKLDKLGL-WVHCfrsLPDVNDDSQRR 90
gi 281353596  17 LVGVVLALVAVVTDHW--AV---LSPELDhh-------------------nATCEAAHFGL-WRICtkrIVMTDSKDKTC 71
gi 18859891   16 IIATALLAIAFSTDNW--LH---YDVWRNQIqsfaakhsdaesllhnmnvkYYYYTRTRGL-FRICypkERPPVSAVPTY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82173356   74 ----------------------------ISIAAPFAPAEIPVAQ-------VLM-MLAVVAGL-VANICGAVamrlvyfs 116
gi 123888131 125 vcgplhlqgesnc---tffkfyttgeniVLFQKTPEKDLTVASAmfaiislFLM-VMGAICII-MAVSKGVQ-------- 191
gi 121956500  86 ffvgcrwvyd---------pfttgydeiRGFLIPPFMIATQFFYtlctigvILSmIMVLFFFL-CAGPDQKFf------- 148
gi 123885913  79 nfwftnqaptkncthaylspfpqnrdnsNSTSYHSALVYRGFWNifmllgvVTA-VIGGFLII-CAAPFTNH-------- 148
gi 170050791  67 fsgcmw----------------ifeeeyYILHDYILPGFFIAVQffftlcfTLL-LLGILMTL-LFLVCSKDndr----- 123
gi 195475702  67 fngclw----------------vfeeeyYIIHDFLLPGFYISVQlfa-tlcFVM-CLVVIPLT-AAFLRTSRddd----- 122
gi 241814021  93 ----------------------------------LLPGWFMFVQsmmtlalMFA-FTALVLVS-ILLMRFLLrf------ 130
gi 195126845  91 ffvgcrwvyd---------pftkgydeiRGFLLPAFMITTQFFYtltfigmLVS-AIGVLVFFlCAGPDQKYf------- 153
gi 281353596  72 gpitlpgekncs-----yfrhfnpgetsEIFHVTTQKEYSISAAaiaifslGFI-IMGTTCAL-LSFPKKRD-------- 136
gi 18859891   90 lspiethcsni------dyfpqaedekiANEDATSRLHLARSCIalfiisfVTI-FCAFWTGL-SGCWKRSS-------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82173356  117 vadrrnmrLVFVLAGMLYL-----LTSGLCLVPLLWNINSVA--KNNTIDFPQEFQLP-SAPVRQQIGSAIGVGIFASVL 188
gi 123888131 192 --------FFLKPAAVCFI-----LSGVLIFLGLIVFHQSV---LSF------LASDQ-SIPLRHQMSWSVTCVGCAGAL 248
gi 121956500 149 -------lKLIRTMGFLTL-----ASGISGGIGVIVFAIFGN--K------DKWMPEH-ANN---WFGWSFILACIGAVA 204
gi 123885913 149 --------RIYKAGGGLFI-----TSGILFALVVVMHVFWVQsvSDIKGYTDTRQQDCsQFTVYVSFGWSFMLAPFGIFF 215
gi 170050791 124 ------yiMLLLTNGTTMV-----VGAICGLIAVLTFGCYGD--SRD------WMPNW-EHN---GMGWAFALGVVGVFA 180
gi 195475702 123 -----rymVLLLAIGSCQV-----VGSVFGFIAVVTFGAKGD--------SRDWMPGW-QNN---DMGWSFALGVVGAVL 180
gi 241814021 131 ------eiIVLMVAFILEA-----ITSIPLFLSVAVFGGMC-----FERS---W---L-QNPIYNHLSWAYALAVVAFFF 187
gi 195126845 154 -------iTLIRSVGYVLL-----GAGVCAAIAVIVFAVFG--------NRNGWMPEH-ANN---WFGWSFVMACVGTVL 209
gi 281353596 137 --------YLXPAR----------PAGLCIFVSVEVTRQSVK--RM-------IDSEH-TVWIEYNYSWSFACACAAFVL 188
gi 18859891  154 --------GAITATSILLLvtcllAAGAMGLWHTVEFFEKEK--VVGEDYFQQWNTVL-RDNTKIAYDWSYIVAWAGIGT 222
                        250
                 ....*....|
gi 82173356  189 SLISGLLFLS 198
gi 123888131 249 VVVAGVLFLV 258
gi 121956500 205 CGIAASLFLT 214
gi 123885913 216 CLFAGMLFLL 225
gi 170050791 181 LFPAGILFIV 190
gi 195475702 181 LLPAGVLYLV 190
gi 241814021 188 HTVAAMMLLG 197
gi 195126845 210 TLVAATLFLT 219
gi 281353596 189 LFLGGLALLL 198
gi 18859891  223 CLLASILLSG 232
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